PMID- 25863595
OWN - NLM
STAT- MEDLINE
DCOM- 20150925
LR  - 20181113
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Print)
IS  - 0013-9351 (Linking)
VI  - 140
DP  - 2015 Jul
TI  - Changes in persistent organic pollutant levels from adolescence to young 
      adulthood.
PG  - 214-24
LID - S0013-9351(15)00080-8 [pii]
LID - 10.1016/j.envres.2015.03.009 [doi]
AB  - Elimination rates and their corresponding half-lives are conceptually important 
      and intuitively accessible pharmacokinetic measures of toxicant elimination, but 
      regression-based estimates are biased proportional to the degree of continuing 
      (background) exposure. We propose an alternative estimator, the censored normal 
      regression model, which uses all observations, but treats individuals whose 
      initial level failed to exceed their follow-up level as censored observations to 
      weight the regression estimates from those that declined between blood draws. In 
      this manner, we derive the intrinsic elimination rate, the elimination rate free 
      from ongoing exposure, as a parameter in a regression with an unobserved, latent 
      dependent variable. We utilize sequential measurements of persistent organic 
      pollutants (POPs) levels from adolescence to adulthood, a period of intense 
      change in size and body composition, to quantify individual-level change within a 
      community exposed to significant quantities of contaminants over an extended 
      period of time. Although much research has been conducted on effects of POPs, far 
      less attention has been given to vectors of intake and changes in toxicant levels 
      during the life course. We apply exploratory factor analysis (EFA) to types and 
      timing of consumption, along with physical behavioral characteristics, to 
      identify a structure of seven underlying factors. Although several variables show 
      factorial complexity, the latent constructs included an age/maturation and 
      period-related factor, a nutritional composite, consumption prior to pregnancy, 
      fish and fowl consumed during pregnancy, factors distinguishing body mass and 
      weight from height, and bottom-feeding fish consumption. Unadjusted and adjusted 
      half-lives using the censored normal regression estimator, as well as estimated 
      half-lives from conventional log concentration regressions, are reported for PCB 
      groupings, specific congeners, p,p'-DDE, and HCB.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Gallo, Mia V
AU  - Gallo MV
AD  - University at Albany, Department of Anthropology, A&S 237, 1400 Washington 
      Avenue, Albany, NY, USA; Center for the Elimination of Minority Health 
      Disparities, University at Albany-SUNY, 1400 Washington Avenue, Albany, NY, USA. 
      Electronic address: mvgallo@albany.edu.
FAU - Deane, Glenn D
AU  - Deane GD
AD  - University at Albany, Department of Sociology, A&S 339, 1400 Washington Avenue, 
      Albany, NY, USA.
FAU - DeCaprio, Anthony P
AU  - DeCaprio AP
AD  - Florida International University, Department of Chemistry & Biochemistry, 
      11200S.W. 8th St., Miami, FL, USA.
FAU - Schell, Lawrence M
AU  - Schell LM
AD  - University at Albany, Department of Anthropology, A&S 237, 1400 Washington 
      Avenue, Albany, NY, USA; Center for the Elimination of Minority Health 
      Disparities, University at Albany-SUNY, 1400 Washington Avenue, Albany, NY, USA; 
      University at Albany, Department of Epidemiology and Biostatistics, School of 
      Public Health One University Place, Room 131, Rensselaer, NY, USA.
CN  - Akwesasne Task Force on the Environment
LA  - eng
GR  - P20 MD003373/MD/NIMHD NIH HHS/United States
GR  - ES10904/ES/NIEHS NIH HHS/United States
GR  - R01 ES010904/ES/NIEHS NIH HHS/United States
GR  - ESO4913/PHS HHS/United States
GR  - MD003373/MD/NIMHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150410
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Environmental Exposure
MH  - Environmental Pollutants/*analysis/pharmacokinetics/toxicity
MH  - Female
MH  - Half-Life
MH  - Humans
MH  - Male
MH  - Models, Theoretical
MH  - Organic Chemicals/*analysis/pharmacokinetics/toxicity
MH  - Young Adult
PMC - PMC4544721
MID - NIHMS680187
OTO - NOTNLM
OT  - DDT
OT  - HCB
OT  - Hexachlorobenzene
OT  - Mohawk
OT  - Native American
OT  - PCBs
OT  - POPs
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyls
OT  - p,p'-DDE
OT  - p,p'-dichlorophenyldichloroethylene
EDAT- 2015/04/13 06:00
MHDA- 2015/09/26 06:00
PMCR- 2016/07/01
CRDT- 2015/04/13 06:00
PHST- 2014/08/20 00:00 [received]
PHST- 2015/03/10 00:00 [revised]
PHST- 2015/03/12 00:00 [accepted]
PHST- 2015/04/13 06:00 [entrez]
PHST- 2015/04/13 06:00 [pubmed]
PHST- 2015/09/26 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - S0013-9351(15)00080-8 [pii]
AID - 10.1016/j.envres.2015.03.009 [doi]
PST - ppublish
SO  - Environ Res. 2015 Jul;140:214-24. doi: 10.1016/j.envres.2015.03.009. Epub 2015 
      Apr 10.