PMID- 25863669
OWN - NLM
STAT- MEDLINE
DCOM- 20160226
LR  - 20181113
IS  - 1875-8312 (Electronic)
IS  - 1569-5794 (Linking)
VI  - 31
IP  - 5
DP  - 2015 Jun
TI  - The impact of infarct size on regional and global left ventricular systolic 
      function: a cardiac magnetic resonance imaging study.
PG  - 1037-44
LID - 10.1007/s10554-015-0657-3 [doi]
AB  - Myocardial infarction (MI) results in myocardial scarring which can have an 
      impact on left ventricular (LV) stiffness and contractile function, ultimately 
      leading to reduced LV systolic function and LV remodelling, However some concerns 
      about the relation between scar extension and segmental wall motion contractility 
      is not enough clear. Thus, the association between myocardial scar, LV regional 
      and global function and LV remodeling should be investigated. We studied the 
      relationship between scar extension, wall motion score index (WMSI), LV 
      dimensions and systolic function in a group of patients with previous MI by 
      cardiac magnetic resonance (CMR). 133 patients with previous (>6 month) MI were 
      retrospectively enrolled in the study. Indexed end-systolic volume (ESVi), 
      indexed end-diastolic volume (EDVi), LV ejection fraction (EF), stroke volume 
      (SV), LV mass were measured using CMR. WMSI and sum scar score (SSS) were also 
      measured following AHA\ACC criteria giving an arbitrary cut-off to distinguish 
      larger from restricted late gadolinium enhancement (LGE) area. A total of 2261 
      segments were studied: regional wall motion abnormalities were present in 1032 
      segments (45%) and 724 (32%) showed presence of MI (LGE). WMSI correlated 
      significantly with EF (r = -0.87, p < 0.0001) in all patients and in both 
      patients with EF >/= 40% (r = -0.77, p < 0.0001) and EF < 40% (r = -0.68, p < 
      0.0001). WMSI also correlated significantly with SSS (r = 0.57, p < 0.0001). The 
      correlation between WMSI and SSS was more significant in patients with transmural 
      MI (WMSI 2.1 +/- 0.5 and SSS 17 +/- 8; r = 0.55, p < 0.0001) than with non transmural 
      MI (WMSI 1.6 +/- 0.7 and SSS 6 +/- 4; r = 0.34 and p = 0.02). A significant 
      correlation was also found between EF and SSS (r = -0.55 and p < 0.0001) and 
      between SSS and LV indexed volumes (EDVi; r = 0.44, p < 0.0001 and ESVi; r = 
      0.51, p < 0.0001). Infarct transmurality and extension as expressed as SSS 
      assessed with cardiac MRI has an impact on global and regional systolic function. 
      A multi-parametric score measuring WMSI scar transmurality and extension, could 
      better identify an increased cardiac remodeling after coronary event.
FAU - Palazzuoli, Alberto
AU  - Palazzuoli A
AD  - Cardiology Unit Department of Internal Medicine, S. Maria alle Scotte Hospital 
      Siena, University of Siena, Siena, Italy, palazzuoli2@unisi.it.
FAU - Beltrami, Matteo
AU  - Beltrami M
FAU - Gennari, Luigi
AU  - Gennari L
FAU - Dastidar, A Ghosh
AU  - Dastidar AG
FAU - Nuti, Ranuccio
AU  - Nuti R
FAU - McAlindon, Elisa
AU  - McAlindon E
FAU - Angelini, Gianni D
AU  - Angelini GD
FAU - Bucciarelli-Ducci, Chiara
AU  - Bucciarelli-Ducci C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150412
PL  - United States
TA  - Int J Cardiovasc Imaging
JT  - The international journal of cardiovascular imaging
JID - 100969716
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Aged
MH  - Cicatrix/*diagnosis/pathology/physiopathology
MH  - Contrast Media
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - *Magnetic Resonance Imaging, Cine
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*diagnosis/pathology/physiopathology
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Stroke Volume
MH  - *Systole
MH  - Ventricular Dysfunction, Left/*diagnosis/pathology/physiopathology
MH  - *Ventricular Function, Left
MH  - *Ventricular Remodeling
EDAT- 2015/04/13 06:00
MHDA- 2016/02/27 06:00
CRDT- 2015/04/13 06:00
PHST- 2015/03/03 00:00 [received]
PHST- 2015/04/06 00:00 [accepted]
PHST- 2015/04/13 06:00 [entrez]
PHST- 2015/04/13 06:00 [pubmed]
PHST- 2016/02/27 06:00 [medline]
AID - 10.1007/s10554-015-0657-3 [doi]
PST - ppublish
SO  - Int J Cardiovasc Imaging. 2015 Jun;31(5):1037-44. doi: 10.1007/s10554-015-0657-3. 
      Epub 2015 Apr 12.