PMID- 25864741
OWN - NLM
STAT- MEDLINE
DCOM- 20150625
LR  - 20180816
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 29
IP  - 1
DP  - 2015 Jan-Mar
TI  - Biomarkers for the evaluation of immunological properties during the shikoku 
      walking pilgrimage.
PG  - 51-62
AB  - It is important to determine the immunological properties for the maintenance of 
      health. We chose the Shikoku Walking Pilgrimage to assess the proper biomarkers 
      for the evaluation of immunological properties. We examined whether the Shikoku 
      Walking Pilgrimage could have a positive effect on the mental and physical health 
      of walking participants by using several biomarkers proposed by our laboratory. 
      Twelve non-randomized healthy male volunteers including 3 twice attendees walked 
      the Shikoku Walking Pilgrimage distance of 58.9 km over 3 days. Plasma, serum, 
      urine, and saliva were collected from the volunteers during the pilgrimage and at 
      1 week before and after it. Immunological biomarkers, including lipid metabolism, 
      oxidative stress, immune function, and catecholamines, were measured. 
      Additionally, mood state scores, alertness, autonomic nervous system activity, 
      and body motion levels during sleep were assessed. A significant decrease was 
      observed in the subjective tension-anxiety levels and in the concentrations of 
      serum low-density lipoprotein cholesterol, plasma hydroxyoctadecadienoic acid 
      (HODE), and urine adrenaline during the pilgrimage as compared to the values of 
      these parameters before the participants embarked on the pilgrimage. The serum 
      levels of brain-derived neurotrophic factor (BDNF) were significantly increased 1 
      week after the pilgrimage relative to those assessed previously. No significant 
      differences in subjective fatigue and the flicker perception threshold were 
      observed. These results suggest that the Shikoku Walking Pilgrimage can exert a 
      positive effect on mental and physical health as particularly shown in the 
      reduction of tensionanxiety and oxidative stress without the accompaniment of 
      fatigue. HODE correlated significantly with typical immunological marker natural 
      killer cell activity and immunoglobulin G. This suggests that there are promising 
      biomarkers such as HODE, NK activity, BDNF, LDL-c, and IgG for assessing the 
      immunological properties.
FAU - Yoshino, K
AU  - Yoshino K
AD  - Health Research Institute, National Institute of Advanced Industrial Science and 
      Technology (AIST), Midorigaoka, Ikeda, Osaka, Japan.
FAU - Umeno, A
AU  - Umeno A
AD  - Health Research Institute, National Institute of Advanced Industrial Science and 
      Technology (AIST), Hayashi-cho, Takamatsu, Kagawa, Japan.
FAU - Shichiri, M
AU  - Shichiri M
AD  - Health Research Institute, National Institute of Advanced Industrial Science and 
      Technology (AIST), Midorigaoka, Ikeda, Osaka, Japan.
FAU - Watanabe, H
AU  - Watanabe H
AD  - Health Research Institute, National Institute of Advanced Industrial Science and 
      Technology (AIST), Midorigaoka, Ikeda, Osaka, Japan.
FAU - Ishida, N
AU  - Ishida N
AD  - Health Research Institute, National Institute of Advanced Industrial Science and 
      Technology (AIST), Midorigaoka, Ikeda, Osaka, Japan.
FAU - Kojima, M
AU  - Kojima M
AD  - Health Research Institute, National Institute of Advanced Industrial Science and 
      Technology (AIST), Midorigaoka, Ikeda, Osaka, Japan.
FAU - Iwaki, S
AU  - Iwaki S
AD  - Health Research Institute, National Institute of Advanced Industrial Science and 
      Technology (AIST), Midorigaoka, Ikeda, Osaka, Japan.
FAU - Hagihara, Y
AU  - Hagihara Y
AD  - Health Research Institute, National Institute of Advanced Industrial Science and 
      Technology (AIST), Midorigaoka, Ikeda, Osaka, Japan.
FAU - Nakamura, M
AU  - Nakamura M
AD  - Health Research Institute, National Institute of Advanced Industrial Science and 
      Technology (AIST), Hayashi-cho, Takamatsu, Kagawa, Japan.
FAU - Yoshida, Y
AU  - Yoshida Y
AD  - Health Research Institute, National Institute of Advanced Industrial Science and 
      Technology (AIST), Hayashi-cho, Takamatsu, Kagawa, Jap.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Fatty Acids, Unsaturated)
RN  - 0 (Immunoglobulin G)
RN  - 0 (hydroxyoctadecadienoic acid)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Adult
MH  - Affect/physiology
MH  - Anxiety/immunology/metabolism
MH  - Biomarkers/*analysis/blood/urine
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Cholesterol, LDL/blood
MH  - Epinephrine/urine
MH  - Fatigue/immunology
MH  - Fatty Acids, Unsaturated/blood
MH  - Humans
MH  - Immune System/*physiology
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress
MH  - Walking/*physiology/*psychology
EDAT- 2015/04/14 06:00
MHDA- 2015/06/26 06:00
CRDT- 2015/04/14 06:00
PHST- 2015/04/14 06:00 [entrez]
PHST- 2015/04/14 06:00 [pubmed]
PHST- 2015/06/26 06:00 [medline]
AID - 6 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2015 Jan-Mar;29(1):51-62.