PMID- 25864780
OWN - NLM
STAT- MEDLINE
DCOM- 20151020
LR  - 20151119
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 595
DP  - 2015 May 19
TI  - Plasma gelsolin and matrix metalloproteinase 3 as potential biomarkers for 
      Alzheimer disease.
PG  - 116-21
LID - S0304-3940(15)00295-5 [pii]
LID - 10.1016/j.neulet.2015.04.014 [doi]
AB  - Gelsolin (GSN) levels and matrix metalloproteinase 3 (MMP3) activity have been 
      found to be altered in the plasma in patients with Alzheimer disease (AD). The 
      aim of this study was to determine whether a combination of these proteins with 
      clinical data is specific and sensitive enough for AD diagnosis. In 113 
      non-demented controls and 113 patients with probable AD, the plasma GSN levels 
      were determined using the enzyme-linked immunosorbent assay (ELISA), and the 
      plasma MMP3 activity was determined using casein zymography. Logistic regression 
      and receiver operating characteristic (ROC) curve analysis were used to determine 
      the diagnostic accuracy of these proteins combined with clinical data. Compared 
      with the controls, the AD patients had significantly lower GSN levels and 
      significantly higher MMP3 activity. Moreover, both the GSN level and MMP3 
      activity were significantly correlated with the MMSE scores. In AD patients, the 
      GSN level was negatively correlated with MMP3 activity. ROC curve analysis showed 
      that the specificity and sensitivity were 77% and 75.2%, respectively, for the 
      combination of the following candidate biomarkers: GSN level/the total amount of 
      Abeta42 and Abeta40, plasma MMP3 activity and clinical data. With its relatively high 
      sensitivity and specificity, this combined biomarker panel may have potential for 
      the screening of AD patients.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Peng, Mao
AU  - Peng M
AD  - Department of Neurology, Xuan Wu Hospital of the Capital Medical University, 
      Beijing, China; Center of Alzheimer's Disease, Beijing Institute for Brain 
      Disorders, Beijing, China; Beijing Key Laboratory of Geriatric Cognitive 
      Disorders, China; Key Neurodegenerative Laboratory of Ministry of Education of 
      the People's Republic of China, Beijing, China.
FAU - Jia, Jianping
AU  - Jia J
AD  - Department of Neurology, Xuan Wu Hospital of the Capital Medical University, 
      Beijing, China; Center of Alzheimer's Disease, Beijing Institute for Brain 
      Disorders, Beijing, China; Beijing Key Laboratory of Geriatric Cognitive 
      Disorders, China; Key Neurodegenerative Laboratory of Ministry of Education of 
      the People's Republic of China, Beijing, China.
FAU - Qin, Wei
AU  - Qin W
AD  - Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 
      China; Beijing Key Laboratory of Geriatric Cognitive Disorders, China; Key 
      Neurodegenerative Laboratory of Ministry of Education of the People's Republic of 
      China, Beijing, China. Electronic address: jiajp@vip.126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150409
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Biomarkers)
RN  - 0 (Gelsolin)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*diagnosis
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Female
MH  - Gelsolin/*blood
MH  - Humans
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Mental Status Schedule
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Alzheimer disease
OT  - Biomarker
OT  - Gelsolin
OT  - Matrix metalloproteinase 3
OT  - Plasma
EDAT- 2015/04/14 06:00
MHDA- 2015/10/21 06:00
CRDT- 2015/04/14 06:00
PHST- 2014/12/05 00:00 [received]
PHST- 2015/02/20 00:00 [revised]
PHST- 2015/04/07 00:00 [accepted]
PHST- 2015/04/14 06:00 [entrez]
PHST- 2015/04/14 06:00 [pubmed]
PHST- 2015/10/21 06:00 [medline]
AID - S0304-3940(15)00295-5 [pii]
AID - 10.1016/j.neulet.2015.04.014 [doi]
PST - ppublish
SO  - Neurosci Lett. 2015 May 19;595:116-21. doi: 10.1016/j.neulet.2015.04.014. Epub 
      2015 Apr 9.