PMID- 25868379
OWN - NLM
STAT- MEDLINE
DCOM- 20160421
LR  - 20150522
IS  - 1773-0597 (Electronic)
IS  - 0181-5512 (Linking)
VI  - 38
IP  - 5
DP  - 2015 May
TI  - Nonarteritic anterior ischemic optic neuropathy in young patients.
PG  - 421-6
LID - S0181-5512(15)00059-5 [pii]
LID - 10.1016/j.jfo.2014.11.006 [doi]
AB  - PURPOSE: To determine and report the demographic and clinical features of 
      patients younger than 50 years with nonarteritic anterior ischemic optic 
      neuropathy (NAION). MATERIAL AND METHODS: In this comparative study, we 
      retrospectively reviewed the medical records of 120 patients with NAION. Patients 
      were divided into two groups according to their age; in group I, 44 patients were 
      younger than 50 years, and in group II, 76 patients were older than 50 years. 
      RESULTS: The gender distribution was similar in both main groups. Involvement was 
      bilateral in 50% and 26.3% of patients, respectively (P<0.0001). Diabetes 
      mellitus was present in 63.6% of patients in group I and 47.3% of patients in 
      group II (P=0.009). We found hypertension as a frequent risk factor in group II 
      (P=0.019). There was no significant difference in the initial and final visual 
      acuities of patients between the two groups. Both groups had a significantly 
      thinner peripapillary nerve fiber layer (RNFL) in every quadrant. The relative 
      loss was greatest in the superior quadrant in both groups. We generally observed 
      inferior altitudinal defect and superior RNFL thinning in two groups. In group I, 
      30 eyes (68.1%) demonstrated angiographically diffuse optic disc filling delay of 
      >/=5seconds after choroidal filling confirming ischemia, and 14 (31.8%) eyes with 
      segmental optic disc filling delay. In group II, diffuse optic disc filling delay 
      was seen in 56 of 76 (73.6%) eyes. Segmental optic disc filling delay was present 
      in 20 eyes (26.3%). There was no significant difference in angiographic findings 
      between the two groups (P=0.67). CONCLUSION: We observed that age did not play a 
      significant role in prognosis of NAION. Diabetes is an increased risk for NAION 
      in the young age group, and HT for NAION in the older group. Fellow eye 
      involvement is more frequent in young patients. These patients should be followed 
      closely.
CI  - Copyright (c) 2015 Elsevier Masson SAS. All rights reserved.
FAU - Turkoglu, E B
AU  - Turkoglu EB
AD  - Akdeniz university, faculty of medicine, department of ophthalmology, Antalya, 
      Turkey. Electronic address: drelifbetul@yahoo.com.
FAU - Ilhan, H D
AU  - Ilhan HD
AD  - Akdeniz university, faculty of medicine, department of ophthalmology, Antalya, 
      Turkey.
FAU - Cetinkaya, A
AU  - Cetinkaya A
AD  - Akdeniz university, faculty of medicine, department of ophthalmology, Antalya, 
      Turkey.
FAU - Bilgin, A B
AU  - Bilgin AB
AD  - Akdeniz university, faculty of medicine, department of ophthalmology, Antalya, 
      Turkey.
FAU - Apaydin, K C
AU  - Apaydin KC
AD  - Akdeniz university, faculty of medicine, department of ophthalmology, Antalya, 
      Turkey.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150411
PL  - France
TA  - J Fr Ophtalmol
JT  - Journal francais d'ophtalmologie
JID - 7804128
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Neuropathy, Ischemic/*diagnosis
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Eye
OT  - Jeune
OT  - Nerf optique
OT  - Neuropathie
OT  - Neuropathy
OT  - Optic nerve
OT  - Young
OT  - OEil
EDAT- 2015/04/15 06:00
MHDA- 2016/04/22 06:00
CRDT- 2015/04/15 06:00
PHST- 2014/05/29 00:00 [received]
PHST- 2014/11/03 00:00 [revised]
PHST- 2014/11/11 00:00 [accepted]
PHST- 2015/04/15 06:00 [entrez]
PHST- 2015/04/15 06:00 [pubmed]
PHST- 2016/04/22 06:00 [medline]
AID - S0181-5512(15)00059-5 [pii]
AID - 10.1016/j.jfo.2014.11.006 [doi]
PST - ppublish
SO  - J Fr Ophtalmol. 2015 May;38(5):421-6. doi: 10.1016/j.jfo.2014.11.006. Epub 2015 
      Apr 11.