PMID- 25868740
OWN - NLM
STAT- MEDLINE
DCOM- 20160219
LR  - 20150603
IS  - 1873-507X (Electronic)
IS  - 0031-9384 (Linking)
VI  - 147
DP  - 2015 Aug 1
TI  - Comparing interval and continuous exercise training regimens on neurotrophic 
      factors in rat brain.
PG  - 78-83
LID - S0031-9384(15)00207-3 [pii]
LID - 10.1016/j.physbeh.2015.04.012 [doi]
AB  - The research literature suggests that oxidative stress and pro-inflammatory 
      factors influence neurotrophins in vitro. However, there is insufficient 
      information about their effects on exercise training conditions, especially 
      during high intensity trainings. This study aimed to compare the effects of 
      6weeks of high intensity interval and continuous training regimens on 
      brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic 
      factor (GDNF), hydrogen peroxide (H2O2), and tumor necrosis factor alpha (TNF-alpha) 
      in the rat brain. For this purpose, twenty-four Albino Wistar rats were divided 
      into sedentary control (SC), high intensity interval training (HIIT), and 
      continuous training (CT) groups. Both HIIT and CT regimens increased H2O2 level 
      and TNF-alpha concentration in the brain, and the alterations made were greater 
      following HIIT than CT. In addition, both HIIT and CT regimens increased BDNF and 
      GDNF concentrations significantly, with a higher elevation following HIIT than 
      CT. Furthermore, H2O2 level and TNF-alpha concentration correlated positively with 
      both BDNF and GDNF concentrations. Generally, high intensity interval training 
      regimen, rather than continuous training regimen, is highly potential to improve 
      BDNF and GDNF through a greater increase in H2O2 and TNF-alpha as oxidative stress 
      and pro-inflammatory factors.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Afzalpour, Mohammad Esmaiel
AU  - Afzalpour ME
AD  - Department of Physical Education and Sport Sciences, University of Birjand, 
      Birjand, Iran. Electronic address: mazalpour@birjand.ac.ir.
FAU - Chadorneshin, Hossein Taheri
AU  - Chadorneshin HT
AD  - Exercise Physiology, University of Birjand, Birjand, Iran.
FAU - Foadoddini, Mohsen
AU  - Foadoddini M
AD  - Atherosclerosis and Coronary Research Center, Birjand University of Medical 
      Sciences, Birjand, Iran.
FAU - Eivari, Hossein Abtahi
AU  - Eivari HA
AD  - Department of Clinical Biochemistry, Gonabad University of Medical Sciences, 
      Gonabad, Iran.
LA  - eng
PT  - Journal Article
DEP - 20150411
PL  - United States
TA  - Physiol Behav
JT  - Physiology & behavior
JID - 0151504
RN  - 0 (Nerve Growth Factors)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Animals
MH  - Body Weight
MH  - Brain/*metabolism
MH  - Hydrogen Peroxide/metabolism
MH  - Male
MH  - Nerve Growth Factors/*metabolism
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Wistar
MH  - Statistics, Nonparametric
MH  - Time Factors
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Continuous training
OT  - Glial cell line-derived neurotrophic factor
OT  - Hydrogen peroxide
OT  - Interval training
OT  - Tumor necrosis factor alpha
EDAT- 2015/04/15 06:00
MHDA- 2016/02/20 06:00
CRDT- 2015/04/15 06:00
PHST- 2014/12/25 00:00 [received]
PHST- 2015/02/27 00:00 [revised]
PHST- 2015/04/06 00:00 [accepted]
PHST- 2015/04/15 06:00 [entrez]
PHST- 2015/04/15 06:00 [pubmed]
PHST- 2016/02/20 06:00 [medline]
AID - S0031-9384(15)00207-3 [pii]
AID - 10.1016/j.physbeh.2015.04.012 [doi]
PST - ppublish
SO  - Physiol Behav. 2015 Aug 1;147:78-83. doi: 10.1016/j.physbeh.2015.04.012. Epub 
      2015 Apr 11.