PMID- 25869354
OWN - NLM
STAT- MEDLINE
DCOM- 20150831
LR  - 20150623
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Linking)
VI  - 78
IP  - 1
DP  - 2015 Jul
TI  - Predicting and treating stress-induced vulnerability to epilepsy and depression.
PG  - 128-36
LID - 10.1002/ana.24414 [doi]
AB  - Accumulation of stressful events can render individuals susceptible to develop 
      epilepsy and comorbidities. Whether such vulnerability can be predicted and 
      reversed is not known. Here we show that social defeat, although not producing 
      depression by itself, produced in 50% of rats reduced threshold for status 
      epilepticus (SE), accelerated epileptogenesis, and once epilepsy was induced, 
      depression-like profile and cognitive deficits. Low serum brain-derived 
      neurotrophic factor (BDNF) levels measured before SE identified this vulnerable 
      population. Treatment with a BDNF analog before SE prevented the occurrence of 
      comorbidities. Thus, vulnerability to comorbidities after epilepsy onset due to 
      unresolved past stressful events may be predicted and reversed.
CI  - (c) 2015 American Neurological Association.
FAU - Becker, Christel
AU  - Becker C
AD  - Mixed Unit of Research 119 (UMPC UM 119), Pierre and Marie Curie University-Paris 
      6, Paris.
AD  - Unit 1130, National Institute of Health and Medical Research (INSERM 1130), 
      Paris.
AD  - Unit 8246, National Center for Scientific Research (CNRS 8246), Paris.
AD  - Faculty of Medicine, Paris Descartes University, Sorbonne Paris Cite, Paris.
FAU - Bouvier, Elodie
AU  - Bouvier E
AD  - Mixed Unit of Research 119 (UMPC UM 119), Pierre and Marie Curie University-Paris 
      6, Paris.
AD  - Unit 1130, National Institute of Health and Medical Research (INSERM 1130), 
      Paris.
AD  - Unit 8246, National Center for Scientific Research (CNRS 8246), Paris.
FAU - Ghestem, Antoine
AU  - Ghestem A
AD  - Aix Marseille Universite, INS, 13005, Marseille, France.
AD  - Inserm, UMR_S 1106, 13005, Marseille, France.
FAU - Siyoucef, Safia
AU  - Siyoucef S
AD  - Aix Marseille Universite, INS, 13005, Marseille, France.
AD  - Inserm, UMR_S 1106, 13005, Marseille, France.
FAU - Claverie, Damien
AU  - Claverie D
AD  - Mixed Unit of Research 119 (UMPC UM 119), Pierre and Marie Curie University-Paris 
      6, Paris.
AD  - Unit 1130, National Institute of Health and Medical Research (INSERM 1130), 
      Paris.
AD  - Unit 8246, National Center for Scientific Research (CNRS 8246), Paris.
AD  - Army Institute of Biomedical Research, Bretigny sur Orge.
FAU - Camus, Francoise
AU  - Camus F
AD  - Mixed Unit of Research 119 (UMPC UM 119), Pierre and Marie Curie University-Paris 
      6, Paris.
AD  - Unit 1130, National Institute of Health and Medical Research (INSERM 1130), 
      Paris.
AD  - Unit 8246, National Center for Scientific Research (CNRS 8246), Paris.
FAU - Bartolomei, Fabrice
AU  - Bartolomei F
AD  - Aix Marseille Universite, INS, 13005, Marseille, France.
AD  - Inserm, UMR_S 1106, 13005, Marseille, France.
FAU - Benoliel, Jean-Jacques
AU  - Benoliel JJ
AD  - Mixed Unit of Research 119 (UMPC UM 119), Pierre and Marie Curie University-Paris 
      6, Paris.
AD  - Unit 1130, National Institute of Health and Medical Research (INSERM 1130), 
      Paris.
AD  - Unit 8246, National Center for Scientific Research (CNRS 8246), Paris.
AD  - Department of Biochemistry and Endocrine Oncology, Pitie-Salpetriere Hospital, 
      Paris, France.
FAU - Bernard, Christophe
AU  - Bernard C
AD  - Aix Marseille Universite, INS, 13005, Marseille, France.
AD  - Inserm, UMR_S 1106, 13005, Marseille, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150525
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (6,7-dihydroxyflavone)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Flavones)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Allostasis
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/drug effects/*metabolism
MH  - Cognition Disorders/*metabolism/psychology
MH  - Depression/*metabolism/psychology
MH  - Disease Models, Animal
MH  - Epilepsy/chemically induced/metabolism/psychology
MH  - Excitatory Amino Acid Agonists/toxicity
MH  - Flavones/pharmacology
MH  - Hypothalamo-Hypophyseal System/drug effects/*metabolism
MH  - Kainic Acid/toxicity
MH  - Male
MH  - Pituitary-Adrenal System/drug effects/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - *Social Environment
MH  - Status Epilepticus/chemically induced/*metabolism
MH  - Stress, Psychological/*metabolism/psychology
EDAT- 2015/04/15 06:00
MHDA- 2015/09/01 06:00
CRDT- 2015/04/15 06:00
PHST- 2015/01/07 00:00 [received]
PHST- 2015/03/27 00:00 [revised]
PHST- 2015/03/30 00:00 [accepted]
PHST- 2015/04/15 06:00 [entrez]
PHST- 2015/04/15 06:00 [pubmed]
PHST- 2015/09/01 06:00 [medline]
AID - 10.1002/ana.24414 [doi]
PST - ppublish
SO  - Ann Neurol. 2015 Jul;78(1):128-36. doi: 10.1002/ana.24414. Epub 2015 May 25.