PMID- 25869916
OWN - NLM
STAT- MEDLINE
DCOM- 20160202
LR  - 20150505
IS  - 1532-3129 (Electronic)
IS  - 0021-9975 (Linking)
VI  - 152
IP  - 4
DP  - 2015 May
TI  - Comparison of the pathogenesis of single or dual infections with type 1 and type 
      2 porcine reproductive and respiratory syndrome virus.
PG  - 317-24
LID - S0021-9975(15)00038-9 [pii]
LID - 10.1016/j.jcpa.2015.03.002 [doi]
AB  - The aim of this study was to compare the pathogenicity of single or dual 
      infections with type 1 and type 2 porcine reproductive and respiratory syndrome 
      virus (PRRSV) in pigs. Pigs were inoculated intranasally with type 1 or type 2 
      PRRSV or both viruses together. Pigs infected with type 1 and type 2 PRRSV 
      together had significantly (P <0.05) fewer genomic copies of type 1 PRRSV than 
      did pigs infected with type 1 PRRSV alone. Pigs infected with type 2 PRRSV alone 
      or type 1 and type 2 PRRSV together had significantly (P <0.05) higher gross and 
      microscopical lung lesion scores than did pigs infected with type 1 PRRSV alone. 
      Pigs infected with type 2 PRRSV alone or type 1 and type 2 PRRSV together had 
      significantly (P <0.05) higher scores for PRRSV-positive cells in the lung than 
      did pigs infected with type 1 PRRSV alone. Pigs infected with type 1 PRRSV alone 
      had significantly (P <0.05) higher scores for type 1 PRRSV-positive cells in the 
      lung than did pigs infected with both types of PRRSV together. Pigs infected with 
      both types of PRRSV together developed similar clinical disease and lesions as 
      pigs infected with type 2 PRRSV alone. Significant differences in virulence were 
      not observed between pigs infected with type 2 PRRSV alone and pigs infected with 
      both types of PRRSV together in terms of viraemia, lung lesion score and virus 
      distribution within lung lesions.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Choi, K
AU  - Choi K
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul, Republic of Korea.
FAU - Lee, J
AU  - Lee J
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul, Republic of Korea; General Animal Health Division, Ministry of 
      Agriculture, Food and Rural Affairs, 94 Dasom 2-ro, Government Complex-Sejong, 
      Sejong-si, Republic of Korea.
FAU - Park, C
AU  - Park C
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul, Republic of Korea.
FAU - Jeong, J
AU  - Jeong J
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul, Republic of Korea.
FAU - Chae, C
AU  - Chae C
AD  - College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, 
      Gwanak-gu, Seoul, Republic of Korea. Electronic address: swine@snu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150411
PL  - England
TA  - J Comp Pathol
JT  - Journal of comparative pathology
JID - 0102444
SB  - IM
MH  - Animals
MH  - Lung/*pathology/virology
MH  - Porcine Reproductive and Respiratory Syndrome/*pathology/virology
MH  - *Porcine respiratory and reproductive syndrome virus
MH  - Swine
OTO - NOTNLM
OT  - co-infection
OT  - pig
OT  - porcine reproductive and respiratory syndrome virus
EDAT- 2015/04/15 06:00
MHDA- 2016/02/03 06:00
CRDT- 2015/04/15 06:00
PHST- 2015/01/12 00:00 [received]
PHST- 2015/03/04 00:00 [revised]
PHST- 2015/03/06 00:00 [accepted]
PHST- 2015/04/15 06:00 [entrez]
PHST- 2015/04/15 06:00 [pubmed]
PHST- 2016/02/03 06:00 [medline]
AID - S0021-9975(15)00038-9 [pii]
AID - 10.1016/j.jcpa.2015.03.002 [doi]
PST - ppublish
SO  - J Comp Pathol. 2015 May;152(4):317-24. doi: 10.1016/j.jcpa.2015.03.002. Epub 2015 
      Apr 11.