PMID- 25873429
OWN - NLM
STAT- MEDLINE
DCOM- 20160106
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Apr 15
TI  - Protective effects of low-intensity pulsed ultrasound on aluminum-induced 
      cerebral damage in Alzheimer's disease rat model.
PG  - 9671
LID - 10.1038/srep09671 [doi]
LID - 9671
AB  - The protein expressions of neurotrophic factors can be enhanced by low-intensity 
      pulsed ultrasound (LIPUS) stimulation in the brain. The purpose of this study was 
      to demonstrate the protective effect of LIPUS stimulation against 
      aluminum-induced cerebral damage in Alzheimer's disease rat model. LIPUS was 
      administered 7 days before each aluminum chloride (AlCl3) administration, and 
      concomitantly given with AlCl3 daily for a period of 6 weeks. Neurotrophic 
      factors in hippocampus were measured by western blot analysis. Behavioral changes 
      in the Morris water maze and elevated plus maze were examined in rats after 
      administration of AlCl3. Various biochemical analyses were performed to evaluate 
      the extent of brain damages. LIPUS is capable of prompting levels of 
      brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic 
      factor (GDNF), and vascular endothelial growth factor (VEGF) in rat brain. AlCl3 
      administration resulted in a significant increase in the aluminum concentration, 
      acetylcholinesterase activity and beta-amyloid (Abeta) deposition in AlCl3 treated 
      rats. LIPUS stimulation significantly attenuated aluminum concentration, 
      acetylcholinesterase activity, Abeta deposition and karyopyknosis in AlCl3 treated 
      rats. Furthermore, LIPUS significantly improved memory retention in AlCl3-induced 
      memory impairment. These experimental results indicate that LIPUS has 
      neuroprotective effects against AlCl3-induced cerebral damages and cognitive 
      dysfunction.
FAU - Lin, Wei-Ting
AU  - Lin WT
AD  - Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Chen, Ran-Chou
AU  - Chen RC
AD  - 1] Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming 
      University, Taipei, Taiwan [2] Department of Radiology, Taipei City Hospital, 
      Taipei, Taiwan.
FAU - Lu, Wen-Wei
AU  - Lu WW
AD  - Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming 
      University, Taipei, Taiwan.
FAU - Liu, Shing-Hwa
AU  - Liu SH
AD  - Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, 
      Taiwan.
FAU - Yang, Feng-Yi
AU  - Yang FY
AD  - 1] Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming 
      University, Taipei, Taiwan [2] Biophotonics and Molecular Imaging Research 
      Center, National Yang-Ming University, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150415
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Nerve Growth Factors)
RN  - CPD4NFA903 (Aluminum)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
SB  - IM
MH  - Acetylcholinesterase/metabolism
MH  - Aluminum/*adverse effects
MH  - Alzheimer Disease/genetics/metabolism/*pathology/therapy
MH  - Amyloid beta-Peptides/metabolism
MH  - Animals
MH  - Blood-Brain Barrier/metabolism
MH  - Brain/drug effects/metabolism/pathology/radiation effects
MH  - Cerebral Cortex/drug effects/*pathology/*radiation effects
MH  - Disease Models, Animal
MH  - Enzyme Activation
MH  - Gene Expression
MH  - Male
MH  - Memory
MH  - Nerve Growth Factors/genetics/metabolism
MH  - Permeability
MH  - Rats
MH  - *Ultrasonic Waves
PMC - PMC4397698
EDAT- 2015/04/16 06:00
MHDA- 2016/01/07 06:00
PMCR- 2015/04/15
CRDT- 2015/04/16 06:00
PHST- 2014/11/12 00:00 [received]
PHST- 2015/03/13 00:00 [accepted]
PHST- 2015/04/16 06:00 [entrez]
PHST- 2015/04/16 06:00 [pubmed]
PHST- 2016/01/07 06:00 [medline]
PHST- 2015/04/15 00:00 [pmc-release]
AID - srep09671 [pii]
AID - 10.1038/srep09671 [doi]
PST - epublish
SO  - Sci Rep. 2015 Apr 15;5:9671. doi: 10.1038/srep09671.