PMID- 25873928
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150415
LR  - 20200929
IS  - 1664-5464 (Print)
IS  - 1664-5464 (Electronic)
IS  - 1664-5464 (Linking)
VI  - 5
IP  - 1
DP  - 2015 Jan-Apr
TI  - Association between DNA Methylation of the BDNF Promoter Region and Clinical 
      Presentation in Alzheimer's Disease.
PG  - 64-73
LID - 10.1159/000375367 [doi]
AB  - BACKGROUND/AIMS: In the present study, we examined whether DNA methylation of the 
      brain-derived neurotrophic factor (BDNF) promoter is associated with the 
      manifestation and clinical presentation of Alzheimer's disease (AD). METHODS: Of 
      20 patients with AD and 20 age-matched normal controls (NCs), the DNA methylation 
      of the BDNF promoter (measured using peripheral blood samples) was completely 
      analyzed in 12 patients with AD and 6 NCs. The resulting methylation levels were 
      compared statistically. Next, we investigated the correlation between the DNA 
      methylation levels and the clinical presentation of AD. RESULTS: The total 
      methylation ratio (in %) of the 20 CpG sites was significantly higher in the AD 
      patients (5.08 +/- 5.52%) than in the NCs (2.09 +/- 0.81%; p < 0.05). Of the 20 CpG 
      sites, the methylation level at the CpG4 site was significantly higher in the AD 
      subjects than in the NCs (p < 0.05). Moreover, the methylation level was 
      significantly and negatively correlated with some neuropsychological test 
      subscores (registration, recall, and prehension behavior scores; p < 0.05). 
      CONCLUSION: These results suggest that the DNA methylation of the BDNF promoter 
      may significantly influence the manifestation of AD and might be associated with 
      its neurocognitive presentation.
FAU - Nagata, Tomoyuki
AU  - Nagata T
AD  - Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan ; 
      Division of Molecular Genetics, Institute of DNA Medicine, The Jikei University 
      School of Medicine, Tokyo, Japan.
FAU - Kobayashi, Nobuyuki
AU  - Kobayashi N
AD  - Department of Virology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Ishii, Jumpei
AU  - Ishii J
AD  - Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Shinagawa, Shunichiro
AU  - Shinagawa S
AD  - Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Nakayama, Ritsuko
AU  - Nakayama R
AD  - Division of Molecular Genetics, Institute of DNA Medicine, The Jikei University 
      School of Medicine, Tokyo, Japan.
FAU - Shibata, Nobuto
AU  - Shibata N
AD  - Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
FAU - Kuerban, Bolati
AU  - Kuerban B
AD  - Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
FAU - Ohnuma, Tohru
AU  - Ohnuma T
AD  - Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
FAU - Kondo, Kazuhiro
AU  - Kondo K
AD  - Department of Virology, The Jikei University School of Medicine, Tokyo, Japan.
FAU - Arai, Heii
AU  - Arai H
AD  - Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
FAU - Yamada, Hisashi
AU  - Yamada H
AD  - Division of Molecular Genetics, Institute of DNA Medicine, The Jikei University 
      School of Medicine, Tokyo, Japan.
FAU - Nakayama, Kazuhiko
AU  - Nakayama K
AD  - Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20150304
PL  - Switzerland
TA  - Dement Geriatr Cogn Dis Extra
JT  - Dementia and geriatric cognitive disorders extra
JID - 101564825
PMC - PMC4376924
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - BDNF
OT  - Brain-derived neurotrophic factor
OT  - DNA methylation
OT  - Epigenetics
OT  - Neurotrophic factors
EDAT- 2015/04/16 06:00
MHDA- 2015/04/16 06:01
PMCR- 2015/03/04
CRDT- 2015/04/16 06:00
PHST- 2015/04/16 06:00 [entrez]
PHST- 2015/04/16 06:00 [pubmed]
PHST- 2015/04/16 06:01 [medline]
PHST- 2015/03/04 00:00 [pmc-release]
AID - dee-0005-0064 [pii]
AID - 10.1159/000375367 [doi]
PST - epublish
SO  - Dement Geriatr Cogn Dis Extra. 2015 Mar 4;5(1):64-73. doi: 10.1159/000375367. 
      eCollection 2015 Jan-Apr.