PMID- 25874699
OWN - NLM
STAT- MEDLINE
DCOM- 20160108
LR  - 20190223
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 4
DP  - 2015
TI  - Surgical management for early-stage bilateral breast cancer patients in China.
PG  - e0122692
LID - 10.1371/journal.pone.0122692 [doi]
LID - e0122692
AB  - BACKGROUND: The aim of this study was to investigate the current surgical 
      management strategy for bilateral breast cancer (BBC) patients and to assess the 
      changes in this strategy in China. METHODS: This is a retrospective review of all 
      patients with early-stage BBC who underwent surgical treatment at the Fudan 
      University Shanghai Cancer Center between June 2007 and June 2014. RESULTS: A 
      total of 15,337 patients with primary breast cancer were identified. Of these 
      patients, 218 (1.5%) suffered from synchronous bilateral breast cancer (sBBC), 
      and 296 (2.0%) suffered from metachronous bilateral breast cancer (mBBC). 
      Patients with a lobular carcinoma component, those with estrogen 
      receptor-positive cancer, and those with an accompanying sclerosing adenosis in 
      the affected breast tended to develop BBC. The rates of bilateral mastectomy, 
      breast conserving therapy, reconstruction, and combined surgeries were 86.2%, 
      6.4%, 3.7%, and 3.7%, respectively, for patients with sBBC and 81.1%, 4.4%, 3.0%, 
      and 11.5%, respectively, for patients with mBBC. The interval between bilateral 
      cancers, age at first diagnosis of breast cancer, histopathological type, and 
      stage have significant impacts on the choice of surgery for patients with BBC. 
      CONCLUSIONS: Bilateral mastectomy was the dominant surgical management for 
      patients with BBC in China, despite the increased application of breast 
      reconstruction surgery observed in recent years. Bilateral prosthetic breast 
      reconstruction was the ideal choice for patients with sBBC. Chinese surgeons 
      should take responsibility for patient education and inform their patients about 
      their surgical options.
FAU - Chen, Jia-jian
AU  - Chen JJ
AD  - Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 
      China; Department of Oncology, Shanghai Medical College, Fudan University, 
      Shanghai, China.
FAU - Huang, Nai-si
AU  - Huang NS
AD  - Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 
      China; Department of Oncology, Shanghai Medical College, Fudan University, 
      Shanghai, China.
FAU - Xue, Jing-yan
AU  - Xue JY
AD  - Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 
      China; Department of Oncology, Shanghai Medical College, Fudan University, 
      Shanghai, China.
FAU - Quan, Chen-lian
AU  - Quan CL
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
      China.
FAU - Tan, Yu-long
AU  - Tan YL
AD  - Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 
      China.
FAU - Liu, Guang-yu
AU  - Liu GY
AD  - Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 
      China; Department of Oncology, Shanghai Medical College, Fudan University, 
      Shanghai, China.
FAU - Shao, Zhi-min
AU  - Shao ZM
AD  - Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 
      China; Department of Oncology, Shanghai Medical College, Fudan University, 
      Shanghai, China.
FAU - Wu, Jiong
AU  - Wu J
AD  - Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, 
      China; Department of Oncology, Shanghai Medical College, Fudan University, 
      Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150413
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Breast Neoplasms/epidemiology/pathology/*surgery
MH  - China
MH  - Female
MH  - Humans
MH  - *Mammaplasty
MH  - *Mastectomy
MH  - Middle Aged
MH  - Neoplasm Staging
PMC - PMC4395376
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/04/16 06:00
MHDA- 2016/01/09 06:00
PMCR- 2015/04/13
CRDT- 2015/04/16 06:00
PHST- 2014/12/04 00:00 [received]
PHST- 2015/02/12 00:00 [accepted]
PHST- 2015/04/16 06:00 [entrez]
PHST- 2015/04/16 06:00 [pubmed]
PHST- 2016/01/09 06:00 [medline]
PHST- 2015/04/13 00:00 [pmc-release]
AID - PONE-D-14-53761 [pii]
AID - 10.1371/journal.pone.0122692 [doi]
PST - epublish
SO  - PLoS One. 2015 Apr 13;10(4):e0122692. doi: 10.1371/journal.pone.0122692. 
      eCollection 2015.