PMID- 25875132
OWN - NLM
STAT- MEDLINE
DCOM- 20160408
LR  - 20181113
IS  - 1573-7365 (Electronic)
IS  - 0885-7490 (Print)
IS  - 0885-7490 (Linking)
VI  - 30
IP  - 4
DP  - 2015 Aug
TI  - Patients with type 2 diabetes exhibit cognitive impairment with changes of 
      metabolite concentration in the left hippocampus.
PG  - 1027-34
LID - 10.1007/s11011-015-9670-4 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is associated with cognitive dysfunction. 
      Previous studies have reported the relationship between cerebral metabolite 
      changes and glucose levels. However, the specific aspects of cognition that are 
      affected by metabolic changes in T2DM- related cognitive impairment remain 
      undetermined. In this study, 188 T2DM patients and 266 controls were recruited. 
      Proton magnetic resonance spectra with a single voxel stimulated echo acquisition 
      mode (STEAM) were acquired from the left hippocampus and the frontal lobe. 
      Presence of T2DM negatively affected the scores of Mini-Mental State Examination 
      (MMSE), sub-tests (i.e., attention and language) of MMSE, Montreal Cognitive 
      Assessment (MoCA) according to the Beijing version, and sub-tests (i.e., 
      visuospatial/executive reasoning, attention, and language) of MoCA, rather than 
      the Wechsler Memory Scale - Revised in China (WMS-RC), and all memory sub-tests 
      contained with the MMSE and MoCA frameworks. T2DM positively affected creatine 
      and myoinositol peak areas from the left hippocampus, rather than metabolites in 
      the left frontal lobe. Negative correlations were shown between the left 
      hippocampal myoinositol levels and language scores, and between the left 
      hippocampal creatine levels and visuospatial/executive scores in T2DM. These 
      findings suggest that T2DM may be an independent risk factor for cognitive 
      impairment. Further, the cognitive domains of visuospatial /executive reasoning, 
      attention and language may be predominantly impaired in the early phases of 
      T2DM-related cognitive impairment. In addition, left hippocampal myoinositol and 
      creatine concentrations were associated with cognitive impairment in patients 
      with T2DM.
FAU - Wang, Yue
AU  - Wang Y
AD  - Department of Neurology, East Hospital, Tongji University, Shanghai, China.
FAU - Xu, Xiao-Yun
AU  - Xu XY
FAU - Feng, Chun-Hua
AU  - Feng CH
FAU - Li, Yuan-Ling
AU  - Li YL
FAU - Ge, Xia
AU  - Ge X
FAU - Zong, Gen-Lin
AU  - Zong GL
FAU - Wang, Yi-Bin
AU  - Wang YB
FAU - Feng, Bo
AU  - Feng B
FAU - Zhang, Peng
AU  - Zhang P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150416
PL  - United States
TA  - Metab Brain Dis
JT  - Metabolic brain disease
JID - 8610370
SB  - IM
MH  - Aged
MH  - China/epidemiology
MH  - Cognition Disorders/*diagnosis/epidemiology/*metabolism
MH  - Diabetes Mellitus, Type 2/*diagnosis/epidemiology/*metabolism
MH  - Female
MH  - Hippocampus/*metabolism/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests
PMC - PMC4491369
EDAT- 2015/04/16 06:00
MHDA- 2016/04/09 06:00
PMCR- 2015/04/16
CRDT- 2015/04/16 06:00
PHST- 2014/11/29 00:00 [received]
PHST- 2015/04/07 00:00 [accepted]
PHST- 2015/04/16 06:00 [entrez]
PHST- 2015/04/16 06:00 [pubmed]
PHST- 2016/04/09 06:00 [medline]
PHST- 2015/04/16 00:00 [pmc-release]
AID - 9670 [pii]
AID - 10.1007/s11011-015-9670-4 [doi]
PST - ppublish
SO  - Metab Brain Dis. 2015 Aug;30(4):1027-34. doi: 10.1007/s11011-015-9670-4. Epub 
      2015 Apr 16.