PMID- 25875728
OWN - NLM
STAT- MEDLINE
DCOM- 20151111
LR  - 20221207
IS  - 1469-1809 (Electronic)
IS  - 0003-4800 (Linking)
VI  - 79
IP  - 3
DP  - 2015 May
TI  - Association of monocyte chemoattractant protein-1 (MCP-1)-2518A>G polymorphism 
      with susceptibility to coronary artery disease: a meta-analysis.
PG  - 173-87
LID - 10.1111/ahg.12105 [doi]
AB  - We attempted to systematically elucidate the association between monocyte 
      chemoattractant protein-1 (MCP-1) -2518A>G polymorphism and risk of coronary 
      artery disease (CAD). Eligible studies were identified through PubMed, EBSCO, and 
      Web of Science Databases. The magnitude of MCP-1 polymorphism effect and its 
      possible mode of action on CAD were estimated. The odds ratio (OR) with 95% 
      confidence intervals (CI) were pooled in a specific genetic model to assess the 
      association. A total of 21 studies were involved. There was significant gene 
      effect on CAD risk in the overall population (likelihood ratio test: p < 0.0001). 
      Patients with GG and AG genotypes had 1.435 (95% CI: 1.183-1.740) and 1.087 (95% 
      CI: 1.008-1.172) times higher risk of CAD than those with AA genotype. These gene 
      effects suggested a recessive model to be appropriate. The pooled OR was 1.362 
      (95% CI: 1.137-1.631; puncorrected = 0.001, pFDR = 0.005) in the recessive model. 
      In the ethnicity-stratified analysis, significant association was observed in the 
      Caucasian population (OR = 1.492; 95% CI: 1.106-2.014; puncorrected = 0.009, pFDR 
      = 0.015), whereas no statistical significant association was detected in the 
      Asian population (adjusted p = 0.124). The results suggested that MCP-1 -2518A>G 
      polymorphism may be associated with susceptibility to CAD, especially in 
      Caucasians.
CI  - (c) 2015 John Wiley & Sons Ltd/University College London.
FAU - Bai, Xiao-Yan
AU  - Bai XY
AD  - School of Life Science and Biotechnology, Dalian University of Technology, 
      Dalian, China.
FAU - Li, Shujing
AU  - Li S
FAU - Wang, Miao
AU  - Wang M
FAU - Qu, Xinjian
AU  - Qu X
FAU - Hu, Gaolei
AU  - Hu G
FAU - Xu, Zhaowei
AU  - Xu Z
FAU - Chen, Min
AU  - Chen M
FAU - He, Guo-Wei
AU  - He GW
FAU - Wu, Huijian
AU  - Wu H
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20150227
PL  - England
TA  - Ann Hum Genet
JT  - Annals of human genetics
JID - 0416661
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - Chemokine CCL2/*genetics
MH  - Coronary Artery Disease/*genetics
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Models, Genetic
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - White People/genetics
OTO - NOTNLM
OT  - Coronary artery disease
OT  - meta-analysis
OT  - monocyte chemoattractant protein-1
OT  - polymorphism
EDAT- 2015/04/16 06:00
MHDA- 2015/11/12 06:00
CRDT- 2015/04/16 06:00
PHST- 2014/07/28 00:00 [received]
PHST- 2015/01/03 00:00 [accepted]
PHST- 2015/04/16 06:00 [entrez]
PHST- 2015/04/16 06:00 [pubmed]
PHST- 2015/11/12 06:00 [medline]
AID - 10.1111/ahg.12105 [doi]
PST - ppublish
SO  - Ann Hum Genet. 2015 May;79(3):173-87. doi: 10.1111/ahg.12105. Epub 2015 Feb 27.