PMID- 25876511
OWN - NLM
STAT- MEDLINE
DCOM- 20171222
LR  - 20220317
IS  - 1559-1182 (Electronic)
IS  - 0893-7648 (Linking)
VI  - 53
IP  - 5
DP  - 2016 Jul
TI  - Association of BDNF Polymorphisms with the Risk of Epilepsy: a Multicenter Study.
PG  - 2869-2877
LID - 10.1007/s12035-015-9150-1 [doi]
AB  - Epilepsy is a common neurological disease characterized by recurrent unprovoked 
      seizures. Evidence suggested that abnormal activity of brain-derived neurotrophic 
      factor (BDNF) contributes to the pathogenesis of epilepsy. Some previous studies 
      identified association between genetic variants of BDNF and risk of epilepsy. In 
      this study, this association has been examined in the Hong Kong and Malaysian 
      epilepsy cohorts. Genomic DNA of 6047 subjects (1640 patients with epilepsy and 
      4407 healthy individuals) was genotyped for rs6265, rs11030104, rs7103411, and 
      rs7127507 polymorphisms by using Sequenom MassArray and Illumina HumanHap 
      610-Quad or 550-Duo BeadChip arrays techniques. Results showed significant 
      association between rs6265 T, rs7103411 C, and rs7127507 T and cryptgenic 
      epilepsy risk (p = 0.00003, p = 0.0002, and p = 0.002, respectively) or between 
      rs6265 and rs7103411 and symptomatic epilepsy risk in Malaysian Indians (TT vs. 
      CC, p = 0.004 and T vs. C, p = 0.0002, respectively) as well as between rs6265 T 
      and risk of cryptogenic epilepsy in Malaysian Chinese (p = 0.005). The 
      Trs6265-Crs7103411-Trs7127507 was significantly associated with cryptogenic 
      epilepsy in Malaysian Indians (p = 0.00005). In conclusion, our results suggest 
      that BDNF polymorphisms might contribute to the risk of epilepsy in Malaysian 
      Indians and Chinese.
FAU - Sha'ari, Hidayati Mohd
AU  - Sha'ari HM
AD  - Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, 
      University of Malaya, Lembah Pantai, 59100, Kuala Lumpur, Malaysia.
FAU - Haerian, Batoul Sadat
AU  - Haerian BS
AD  - Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, 
      University of Malaya, Lembah Pantai, 59100, Kuala Lumpur, Malaysia. 
      batoolsadat@yahoo.com.
FAU - Baum, Larry
AU  - Baum L
AD  - School of Pharmacy, The Chinese University of Hong Kong, Shatin, Hong Kong, 
      China. lwbaum@hotmail.com.
FAU - Tan, Hui Jan
AU  - Tan HJ
AD  - Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, 
      Kuala Lumpur, Malaysia.
FAU - Rafia, Mohd Hanip
AU  - Rafia MH
AD  - Division of Neurology, General Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
FAU - Kwan, Patrick
AU  - Kwan P
AD  - Division of Neurology, Department of Medicine and Therapeutics, Prince of Wales 
      Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
FAU - Cherny, Stacey S
AU  - Cherny SS
AD  - Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong, 
      China.
FAU - Sham, Pak Chung
AU  - Sham PC
AD  - Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong, 
      China.
FAU - Gui, Hongsheng
AU  - Gui H
AD  - Department of Psychiatry, The University of Hong Kong, Pokfulam, Hong Kong, 
      China.
FAU - Raymond, Azman Ali
AU  - Raymond AA
AD  - Department of Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, 
      Kuala Lumpur, Malaysia.
FAU - Lim, Kheng Seang
AU  - Lim KS
AD  - Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, 
      Malaysia.
FAU - Mohamed, Zahurin
AU  - Mohamed Z
AD  - Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, 
      University of Malaya, Lembah Pantai, 59100, Kuala Lumpur, Malaysia.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20150416
PL  - United States
TA  - Mol Neurobiol
JT  - Molecular neurobiology
JID - 8900963
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/chemistry/*genetics
MH  - Case-Control Studies
MH  - Demography
MH  - Epilepsy/*genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Hong Kong
MH  - Humans
MH  - Malaysia
MH  - Male
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Risk Factors
OTO - NOTNLM
OT  - BDNF
OT  - Epilepsy
OT  - Polymorphism
OT  - Susceptibility
EDAT- 2015/04/17 06:00
MHDA- 2017/12/23 06:00
CRDT- 2015/04/17 06:00
PHST- 2015/01/16 00:00 [received]
PHST- 2015/03/19 00:00 [accepted]
PHST- 2015/04/17 06:00 [entrez]
PHST- 2015/04/17 06:00 [pubmed]
PHST- 2017/12/23 06:00 [medline]
AID - 10.1007/s12035-015-9150-1 [pii]
AID - 10.1007/s12035-015-9150-1 [doi]
PST - ppublish
SO  - Mol Neurobiol. 2016 Jul;53(5):2869-2877. doi: 10.1007/s12035-015-9150-1. Epub 
      2015 Apr 16.