PMID- 25877052
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150417
LR  - 20150416
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 3
IP  - 4
DP  - 2014 Jul
TI  - Progressive multifocal leukoencephalopathy and JC Virus-related disease in modern 
      neurology practice.
PG  - 419-30
LID - S2211-0348(14)00008-X [pii]
LID - 10.1016/j.msard.2014.01.005 [doi]
AB  - The natural history and clinical import of Progressive Multifocal 
      Leukoencephalopathy has changed enormously in the last thirty years. After a 
      resurgence of PML during the HIV/AIDS epidemic, advances in the treatment of 
      multiple sclerosis created another group of 'at risk' patients. With a focus on 
      issues pertaining to the multiple sclerosis patient population, this review 
      covers pathophysiology of the JC virus, causes of PML, mechanisms by which 
      natalizumab increases the risk of PML, determinants of PML risk in 
      natalizumab-treated patients, risks of natalizumab discontinuation, PML 
      prevention and surveillance, PML imaging features, PML diagnosis and stumbling 
      blocks to making the diagnosis, PML and PML-Immune Reconstitution Inflammatory 
      Syndrome (IRIS) treatment.
CI  - Copyright (c) 2014 Elsevier B.V. All rights reserved.
FAU - Carruthers, Robert L
AU  - Carruthers RL
AD  - Department of Neurology, Harvard Medical School, Boston, MA, USA; Partners 
      Multiple Sclerosis Center, Brigham and Women׳s Hospital, Boston, MA, USA. 
      Electronic address: drrobertcarruthers@gmail.com.
FAU - Berger, Joseph
AU  - Berger J
AD  - Department of Neurology, University of Kentucky Medical Center, Lexington, KY, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20140208
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
OTO - NOTNLM
OT  - JCV
OT  - JCV serology
OT  - Multiple sclerosis
OT  - Natalizumab
OT  - PML-IRIS
OT  - Progressive multifocal leukoencephalopathy
EDAT- 2015/04/17 06:00
MHDA- 2015/04/17 06:01
CRDT- 2015/04/17 06:00
PHST- 2013/12/19 00:00 [received]
PHST- 2014/01/30 00:00 [revised]
PHST- 2014/01/31 00:00 [accepted]
PHST- 2015/04/17 06:00 [entrez]
PHST- 2015/04/17 06:00 [pubmed]
PHST- 2015/04/17 06:01 [medline]
AID - S2211-0348(14)00008-X [pii]
AID - 10.1016/j.msard.2014.01.005 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2014 Jul;3(4):419-30. doi: 10.1016/j.msard.2014.01.005. 
      Epub 2014 Feb 8.