PMID- 25877061
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150417
LR  - 20150416
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 3
IP  - 4
DP  - 2014 Jul
TI  - Association of vitamin D deficiency with RNFL thickness in MS individuals without 
      history of optic neuritis.
PG  - 489-93
LID - S2211-0348(14)00030-3 [pii]
LID - 10.1016/j.msard.2014.03.001 [doi]
AB  - Vitamin D deficiency has been associated with both increased risk and severity of 
      Multiple Sclerosis (MS) as it has a modulating effect on the immune process that 
      causes inflammation/demyelination and axonal damage. Optical Coherence Tomography 
      (OCT) offers a quick, reliable and non-invasive way to assess the Retinal Nerve 
      Fiber Layer (RNFL) and identifies axonal loss generated by either direct 
      inflammation or from neurodegeneration. OBJECTIVE: To determine the association 
      of vitamin D and RNFL in MS patients without a history of Optic Neuritis (ON) by 
      comparing RNFL thickness in patients that are vitamin D deficient with those 
      having normal serum levels. METHOD: The cohort of 76 MS patients underwent OCT 
      testing to assess the RNFL thickness and macular volume, and measurement of serum 
      25-OH Vitamin D level. Vitamin D deficiency was defined as <30ng/ml and 
      sufficiency as >/=30ng/ml. RESULTS: A total of 131 eyes were divided in two groups: 
      vitamin D deficient (n=86 eyes, mean=17.7ng/ml) and vitamin D sufficient (n=45 
      eyes, mean=40.3ng/ml). Twenty one eyes had previous ON and were excluded from 
      this analysis. Vitamin D deficiency was identified in 66% of the participants. 
      RNFL thickness was similar for the vitamin D deficient and sufficient groups 
      (85.5 vs 86mum respectively, p=0.89). Significant differences were present for age 
      with the deficient group being younger (42 years vs 51 years, p=0.005) and having 
      shorter disease duration (7.5 years vs 11.4 years, p=0.006). CONCLUSION: Vitamin 
      D deficiency is not associated with thinning of RNFL or macular volume in MS eyes 
      unaffected by ON. This finding suggests the role of vitamin D in modulating the 
      severity of MS is not exerted through an influence on neurodegeneration.
CI  - Copyright (c) 2014 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Fjeldstad, Cecilie
AU  - Fjeldstad C
AD  - OMRF Multiple Sclerosis Center of Excellence, 820 NE 15th Street, Oklahoma City, 
      OK 73104, USA. Electronic address: Cecilie-Fjeldstad@omrf.org.
FAU - Fjeldstad, Anette S
AU  - Fjeldstad AS
AD  - Department of Neurology, University of Utah, Imaging & Neurosciences Center at 
      Research Park, 729 Arapeen Drive Rm 1172, Salt Lake City, UT 84108, USA. 
      Electronic address: a.fjeldstad@utah.edu.
FAU - Weir, Joseph P
AU  - Weir JP
AD  - Department of Health, Sport, and Exercise Sciences, 1301 Sunnyside Avenue, 
      Robinson center 104D, University of Kansas, Lawrence, KS 66045, USA. Electronic 
      address: joseph.weir@ku.edu.
FAU - Pardo, Gabriel
AU  - Pardo G
AD  - OMRF Multiple Sclerosis Center of Excellence, 820 NE 15th Street, Oklahoma City, 
      OK 73104, USA.
LA  - eng
PT  - Journal Article
DEP - 20140325
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
OTO - NOTNLM
OT  - Multiple sclerosis
OT  - Optic neuritis
OT  - Optical coherence tomography
OT  - Retinal nerve fiber layer
OT  - Vitamin D
EDAT- 2015/04/17 06:00
MHDA- 2015/04/17 06:01
CRDT- 2015/04/17 06:00
PHST- 2013/08/30 00:00 [received]
PHST- 2014/03/11 00:00 [revised]
PHST- 2014/03/17 00:00 [accepted]
PHST- 2015/04/17 06:00 [entrez]
PHST- 2015/04/17 06:00 [pubmed]
PHST- 2015/04/17 06:01 [medline]
AID - S2211-0348(14)00030-3 [pii]
AID - 10.1016/j.msard.2014.03.001 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2014 Jul;3(4):489-93. doi: 10.1016/j.msard.2014.03.001. 
      Epub 2014 Mar 25.