PMID- 25877732
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150417
LR  - 20201229
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 2
IP  - 3
DP  - 2013 Jul
TI  - Rebound exacerbation multiple sclerosis following cessation of oral treatment.
PG  - 252-5
LID - S2211-0348(12)00130-7 [pii]
LID - 10.1016/j.msard.2012.11.001 [doi]
AB  - BACKGROUND: Multiple sclerosis (MS) management is changing, revolutionized by 
      oral agents. Immune Reconstitution Inflammatory Syndrome (IRIS) describes 
      exaggerated response to both exogenous (infective) and endogenous (non-infective) 
      antigens. METHODS: This paper reports two cases of MS "rebound" following 
      withdrawal of oral treatments. RESULTS: Two patients, with suboptimal response to 
      interferons, trialled oral MS treatment (fingolimod and BG12) with excellent 
      response. Upon cessation both experienced MS "rebound" which responded to 
      steroids. CONCLUSIONS: "Rebound" may occur following withdrawal of oral MS 
      therapies. Patients should be advised accordingly and possibly started on 
      alternative treatment before the immunomodulating effect of therapy has subsided.
CI  - Copyright (c) 2013. Published by Elsevier B.V.
FAU - Beran, Roy G
AU  - Beran RG
AD  - Department of Neurology, Liverpool Hospital and The South Western Sydney Clinical 
      School, University of New South Wales, New South Wales (NSW), Australia; School 
      of Medicine, Griffith University, Queensland, Australia; Strategic Health 
      Evaluators, PO Box 598, Northbridge, 1560 NSW, Australia. Electronic address: 
      Roy.Beran@unsw.edu.au.
FAU - Hegazi, Yaser
AU  - Hegazi Y
AD  - Department of Neurology, Liverpool Hospital and The South Western Sydney Clinical 
      School, University of New South Wales, New South Wales (NSW), Australia.
FAU - Schwartz, Raymond S
AU  - Schwartz RS
AD  - Southern Neurology, 2/19 Kensington Street, Kogarah, NSW, Australia.
FAU - Cordato, Dennis J
AU  - Cordato DJ
AD  - Department of Neurology, Liverpool Hospital and The South Western Sydney Clinical 
      School, University of New South Wales, New South Wales (NSW), Australia; Southern 
      Neurology, 2/19 Kensington Street, Kogarah, NSW, Australia.
LA  - eng
PT  - Journal Article
DEP - 20121221
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
OTO - NOTNLM
OT  - BG12
OT  - Fingolimod
OT  - Multiple sclerosis
OT  - Rebound
EDAT- 2013/07/01 00:00
MHDA- 2013/07/01 00:01
CRDT- 2015/04/17 06:00
PHST- 2012/06/13 00:00 [received]
PHST- 2012/10/04 00:00 [revised]
PHST- 2012/11/12 00:00 [accepted]
PHST- 2015/04/17 06:00 [entrez]
PHST- 2013/07/01 00:00 [pubmed]
PHST- 2013/07/01 00:01 [medline]
AID - S2211-0348(12)00130-7 [pii]
AID - 10.1016/j.msard.2012.11.001 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2013 Jul;2(3):252-5. doi: 10.1016/j.msard.2012.11.001. 
      Epub 2012 Dec 21.