PMID- 25878254
OWN - NLM
STAT- MEDLINE
DCOM- 20160225
LR  - 20181113
IS  - 1556-679X (Electronic)
IS  - 1556-6811 (Print)
IS  - 1556-679X (Linking)
VI  - 22
IP  - 6
DP  - 2015 Jun
TI  - Normal free interleukin-18 (IL-18) plasma levels in dengue virus infection and 
      the need to measure both total IL-18 and IL-18 binding protein levels.
PG  - 650-5
LID - 10.1128/CVI.00147-15 [doi]
AB  - Activated monocytes/macrophages and T lymphocytes that produce a cytokine storm 
      are assumed to play a pivotal role in the pathogenesis of dengue. Interleukin-18 
      (IL-18) is a proinflammatory cytokine that is increased during dengue and known 
      to induce gamma interferon (IFN-gamma), which is crucial for dengue immune response. 
      No data are available regarding the balance between IL-18 and its natural 
      inhibitor IL-18 binding protein (IL-18BP) and how they interact within the 
      inflammatory reaction of patients with dengue virus infections. Circulating 
      levels of IL-18; IL-18BP; free, biologically active IL-18; the IL-18-dependent 
      proinflammatory cytokine IFN-gamma; monocyte-derived cytokines; and ferritin were 
      assessed in adult Indonesian dengue patients (n = 95). Healthy individuals (n = 
      22) and leptospirosis (n = 19) and enteric fever (n = 6) patients served as 
      controls. Total IL-18 levels were increased during dengue, leptospirosis, and 
      enteric fever compared to healthy controls. However, due to a concurrent increase 
      in IL-18BP levels, biologically active IL-18 levels remained similar in the 
      different phases of dengue and in patients with leptospirosis. Biologically 
      active IL-18 levels were also similar in patients with severe and nonsevere 
      dengue. In conclusion, high total IL-18 and IL-18BP levels concur in dengue virus 
      infections, leptospirosis, and enteric fever. This resulted in unchanged levels 
      of free, biologically active IL-18 in dengue and leptospirosis, which underlines 
      the importance of measuring both IL-18 and IL-18BP when studying the role of 
      IL-18 in diseases.
CI  - Copyright (c) 2015, American Society for Microbiology. All Rights Reserved.
FAU - Michels, Meta
AU  - Michels M
AD  - Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The 
      Netherlands Meta.Michels@radboudumc.nl.
FAU - de Mast, Quirijn
AU  - de Mast Q
AD  - Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The 
      Netherlands.
FAU - Netea, Mihai G
AU  - Netea MG
AD  - Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The 
      Netherlands.
FAU - Joosten, Leo A
AU  - Joosten LA
AD  - Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The 
      Netherlands.
FAU - Dinarello, Charles A
AU  - Dinarello CA
AD  - Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The 
      Netherlands.
FAU - Rudiman, Pandji I F
AU  - Rudiman PI
AD  - Department of Internal Medicine, Faculty of Medicine, University of Padjadjaran, 
      Bandung, Indonesia.
FAU - Sinarta, Sylvia
AU  - Sinarta S
AD  - Department of Internal Medicine, Faculty of Medicine, University of Padjadjaran, 
      Bandung, Indonesia.
FAU - Wisaksana, Rudi
AU  - Wisaksana R
AD  - Department of Internal Medicine, Faculty of Medicine, University of Padjadjaran, 
      Bandung, Indonesia.
FAU - Alisjahbana, Bachti
AU  - Alisjahbana B
AD  - Department of Internal Medicine, Faculty of Medicine, University of Padjadjaran, 
      Bandung, Indonesia.
FAU - van der Ven, Andre J A M
AU  - van der Ven AJ
AD  - Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The 
      Netherlands.
LA  - eng
GR  - AI-15614/AI/NIAID NIH HHS/United States
GR  - R01 AI015614/AI/NIAID NIH HHS/United States
GR  - R01 AR045584/AR/NIAMS NIH HHS/United States
GR  - AR-45584/AR/NIAMS NIH HHS/United States
GR  - R56 AI015614/AI/NIAID NIH HHS/United States
GR  - CA-046934/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150415
PL  - United States
TA  - Clin Vaccine Immunol
JT  - Clinical and vaccine immunology : CVI
JID - 101252125
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin-18)
RN  - 0 (interleukin-18 binding protein)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Dengue/immunology/*pathology
MH  - Female
MH  - Humans
MH  - Indonesia
MH  - Intercellular Signaling Peptides and Proteins/*blood
MH  - Interleukin-18/*blood
MH  - Leptospirosis/immunology/pathology
MH  - Male
MH  - Plasma/*chemistry
MH  - Prospective Studies
MH  - Typhoid Fever/immunology/pathology
MH  - Young Adult
PMC - PMC4446409
EDAT- 2015/04/17 06:00
MHDA- 2016/02/26 06:00
PMCR- 2015/12/01
CRDT- 2015/04/17 06:00
PHST- 2015/03/14 00:00 [received]
PHST- 2015/04/09 00:00 [accepted]
PHST- 2015/04/17 06:00 [entrez]
PHST- 2015/04/17 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - CVI.00147-15 [pii]
AID - 00147-15 [pii]
AID - 10.1128/CVI.00147-15 [doi]
PST - ppublish
SO  - Clin Vaccine Immunol. 2015 Jun;22(6):650-5. doi: 10.1128/CVI.00147-15. Epub 2015 
      Apr 15.