PMID- 25879672
OWN - NLM
STAT- MEDLINE
DCOM- 20160801
LR  - 20221207
IS  - 1478-3231 (Electronic)
IS  - 1478-3223 (Linking)
VI  - 35
IP  - 11
DP  - 2015 Nov
TI  - Non-alcoholic fatty liver disease predicts type 2 diabetes mellitus, but not 
      prediabetes, in Xi'an, China: a five-year cohort study.
PG  - 2401-7
LID - 10.1111/liv.12851 [doi]
AB  - BACKGROUND & AIMS: Emerging studies have focused the association between 
      non-alcoholic fatty liver disease (NAFLD) and the risk of type 2 diabetes 
      mellitus (T2DM) but the results were inconsistent. In addition, few studies have 
      put focus on the association between NAFLD and the risk of prediabetes. We aimed 
      to investigate whether NAFLD diagnosed by ultrasonography could predict the risk 
      of future T2DM and prediabetes in Chinese population. METHODS: The 
      population-based cohort study held in Xi'an, Northwestern China, was based on 
      China National Diabetes and Metabolic Disorders Survey. During a follow-up of 
      5 years, 508 healthy subjects were included as study sample. NAFLD was determined 
      by abdominal ultrasonography. T2DM and prediabetes were diagnosed based on oral 
      glucose tolerance test. RESULTS: Of 508 subjects, 97 (19.1%) were diagnosed as 
      NAFLD and 411 (80.9%) were as non-NAFLD; 20 (3.9%) developed diabetes and 85 
      (16.7%) developed prediabetes during follow-up. The incidence of diabetes and 
      prediabetes in the NAFLD group was 20.6 and 51.6 per 1000 person-years, 
      respectively, whereas that in non-NAFLD group was 4.9 and 29.2 per 1000 
      person-years respectively. Cox proportional hazard regression showed that the 
      multivariable-adjusted relative risk (RR) of T2DM and prediabetes in the NAFLD 
      group was 4.462 [95% confidence interval (CI): 1.855-10.734, P < 0.001] and 1.642 
      (95% CI: 0.965-2.793, P = 0.067), respectively, compared with non-NAFLD group. 
      CONCLUSIONS: Non-alcoholic fatty liver disease was a significant predictor for 
      future diabetes, but not for prediabetes, in Xi'an, China. More cohort studies 
      are needed to confirm our findings.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Ming, Jie
AU  - Ming J
AD  - Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Xu, Shaoyong
AU  - Xu S
AD  - Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Gao, Bin
AU  - Gao B
AD  - Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Liu, Guocai
AU  - Liu G
AD  - Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
AD  - Department of Infectious Diseases, 273 Hospital of PLA, Kuele, China.
FAU - Ji, Yufei
AU  - Ji Y
AD  - Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Jia, Yunan
AU  - Jia Y
AD  - Department of Internal Medicine, Avic Xi'an Aero-engine (Group) Hospital, Xi'an, 
      China.
FAU - Fang, Yujie
AU  - Fang Y
AD  - Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
FAU - Ji, Qiuhe
AU  - Ji Q
AD  - Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, 
      Xi'an, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150505
PL  - United States
TA  - Liver Int
JT  - Liver international : official journal of the International Association for the 
      Study of the Liver
JID - 101160857
SB  - IM
CIN - Liver Int. 2015 Dec;35(12):2621. PMID: 25939859
CIN - Liver Int. 2015 Dec;35(12):2622. PMID: 25966042
MH  - Adult
MH  - Asian People
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/*epidemiology
MH  - Female
MH  - Glucose Tolerance Test/methods
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Non-alcoholic Fatty Liver Disease/blood/diagnostic imaging/*epidemiology
MH  - Prediabetic State/blood/*epidemiology
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - Ultrasonography
OTO - NOTNLM
OT  - cohort study
OT  - non-alcoholic fatty liver disease
OT  - oral glucose tolerance test
OT  - population-based study
OT  - prediabetes
OT  - type 2 diabetes mellitus
EDAT- 2015/04/17 06:00
MHDA- 2016/08/02 06:00
CRDT- 2015/04/17 06:00
PHST- 2015/02/10 00:00 [received]
PHST- 2015/04/11 00:00 [accepted]
PHST- 2015/04/17 06:00 [entrez]
PHST- 2015/04/17 06:00 [pubmed]
PHST- 2016/08/02 06:00 [medline]
AID - 10.1111/liv.12851 [doi]
PST - ppublish
SO  - Liver Int. 2015 Nov;35(11):2401-7. doi: 10.1111/liv.12851. Epub 2015 May 5.