PMID- 25879825
OWN - NLM
STAT- MEDLINE
DCOM- 20170215
LR  - 20181202
IS  - 1865-1682 (Electronic)
IS  - 1865-1674 (Linking)
VI  - 64
IP  - 1
DP  - 2017 Feb
TI  - Two Commercial Type 1 Porcine Reproductive and Respiratory Syndrome Virus 
      (PRRSV)-Modified Live Vaccines Reduce Seminal Shedding of Type 1 PRRSV but not 
      Type 2 PRRSV in Infected Boars.
PG  - 194-203
LID - 10.1111/tbed.12361 [doi]
AB  - The objective of this study was to compare the effects of two commercial type 1 
      porcine reproductive and respiratory syndrome virus (PRRSV)-modified live 
      vaccines on type 1 and type 2 PRRSV shedding in the semen of experimentally 
      infected boars. Upon challenge with PRRSV, unvaccinated boars exhibited an 
      increase in daily rectal temperature (39.4-39.7 degrees C). Vaccination of boars with 
      type 1 PRRSV significantly reduced the amount of type 1 PRRSV load in blood and 
      semen after challenge with type 1 PRRSV, but barely reduced the amount of type 2 
      PRRSV load in blood and semen after the type 2 PRRSV challenge. There were no 
      significant differences in the reduction of viremia and seminal shedding of type 
      1 and type 2 PRRSV between the two commercial vaccines. The seminal shedding of 
      PRRSV is independent of viremia. The reduction of type 1 PRRSV seminal shedding 
      coincided with the appearance of type 1 PRRSV-specific interferon-gamma secreting 
      cells (IFN-gamma-SC) in vaccinated type 1 PRRSV-challenged boars. The frequencies of 
      type 1 PRRSV-specific IFN-gamma-SC induced by type 1 PRRSV vaccine are relatively 
      high compared to type 2 PRRSV-specific IFN-gamma-SC induced by the same vaccine which 
      may explain why type 1 PRRSV vaccine is more effective in reducing seminal 
      shedding of type 1 PRRSV when compared to type 2 PRRSV in vaccinated challenged 
      boars. These results provide clinical information on how to reduce seminal 
      shedding of type 1 PRRSV in boars using type 1 PRRSV-modified live vaccine.
CI  - (c) 2015 Blackwell Verlag GmbH.
FAU - Park, C
AU  - Park C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Kim, T
AU  - Kim T
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Choi, K
AU  - Choi K
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Jeong, J
AU  - Jeong J
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Kang, I
AU  - Kang I
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Park, S-J
AU  - Park SJ
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
FAU - Chae, C
AU  - Chae C
AD  - Department of Veterinary Pathology, College of Veterinary Medicine, Seoul 
      National University, Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20150416
PL  - Germany
TA  - Transbound Emerg Dis
JT  - Transboundary and emerging diseases
JID - 101319538
RN  - 0 (Vaccines, Attenuated)
RN  - 0 (Viral Vaccines)
SB  - IM
MH  - Animals
MH  - Porcine Reproductive and Respiratory Syndrome/*therapy/virology
MH  - Porcine respiratory and reproductive syndrome virus/*immunology
MH  - Semen/virology
MH  - Swine
MH  - Vaccines, Attenuated/immunology
MH  - Viral Vaccines/*immunology
MH  - *Virus Shedding
OTO - NOTNLM
OT  - boar
OT  - cross-protection
OT  - porcine reproductive and respiratory syndrome virus
OT  - semen
OT  - vaccine
EDAT- 2015/04/17 06:00
MHDA- 2017/02/16 06:00
CRDT- 2015/04/17 06:00
PHST- 2015/01/04 00:00 [received]
PHST- 2015/04/17 06:00 [pubmed]
PHST- 2017/02/16 06:00 [medline]
PHST- 2015/04/17 06:00 [entrez]
AID - 10.1111/tbed.12361 [doi]
PST - ppublish
SO  - Transbound Emerg Dis. 2017 Feb;64(1):194-203. doi: 10.1111/tbed.12361. Epub 2015 
      Apr 16.