PMID- 25880375 OWN - NLM STAT- MEDLINE DCOM- 20160415 LR - 20201217 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 10 IP - 4 DP - 2015 TI - GPU-accelerated framework for intracoronary optical coherence tomography imaging at the push of a button. PG - e0124192 LID - 10.1371/journal.pone.0124192 [doi] LID - e0124192 AB - Frequency domain optical coherence tomography (FD-OCT) has become one of the important clinical tools for intracoronary imaging to diagnose and monitor coronary artery disease, which has been one of the leading causes of death. To help more accurate diagnosis and monitoring of the disease, many researchers have recently worked on visualization of various coronary microscopic features including stent struts by constructing three-dimensional (3D) volumetric rendering from series of cross-sectional intracoronary FD-OCT images. In this paper, we present the first, to our knowledge, "push-of-a-button" graphics processing unit (GPU)-accelerated framework for intracoronary OCT imaging. Our framework visualizes 3D microstructures of the vessel wall with stent struts from raw binary OCT data acquired by the system digitizer as one seamless process. The framework reports the state-of-the-art performance; from raw OCT data, it takes 4.7 seconds to provide 3D visualization of a 5-cm-long coronary artery (of size 1600 samples x 1024 A-lines x 260 frames) with stent struts and detection of malapposition automatically at the single push of a button. FAU - Han, Myounghee AU - Han M AD - Department of Computer Science, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. FAU - Kim, Kyunghun AU - Kim K AD - Department of Computer Science, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. FAU - Jang, Sun-Joo AU - Jang SJ AD - Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. FAU - Cho, Han Saem AU - Cho HS AD - Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. FAU - Bouma, Brett E AU - Bouma BE AD - Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, Boston, United States of America. FAU - Oh, Wang-Yuhl AU - Oh WY AD - Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. FAU - Ryu, Sukyoung AU - Ryu S AD - Department of Computer Science, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea. LA - eng GR - P41 EB015903/EB/NIBIB NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150416 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - *Automation MH - Computer Graphics/*instrumentation MH - Coronary Vessels/*diagnostic imaging MH - Humans MH - Stents MH - Tomography, Optical Coherence/*instrumentation MH - Ultrasonography PMC - PMC4400174 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2015/04/17 06:00 MHDA- 2016/04/16 06:00 PMCR- 2015/04/16 CRDT- 2015/04/17 06:00 PHST- 2015/01/12 00:00 [received] PHST- 2015/02/26 00:00 [accepted] PHST- 2015/04/17 06:00 [entrez] PHST- 2015/04/17 06:00 [pubmed] PHST- 2016/04/16 06:00 [medline] PHST- 2015/04/16 00:00 [pmc-release] AID - PONE-D-15-01361 [pii] AID - 10.1371/journal.pone.0124192 [doi] PST - epublish SO - PLoS One. 2015 Apr 16;10(4):e0124192. doi: 10.1371/journal.pone.0124192. eCollection 2015.