PMID- 25881457
OWN - NLM
STAT- MEDLINE
DCOM- 20150901
LR  - 20181202
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 35
IP  - 2
DP  - 2015 Feb
TI  - [Correlation study between lupus nephritis patients of rheumatism syndrome and 
      SLEDAI--a clinical study].
PG  - 147-50
AB  - OBJECTIVE: To explore lupus nephritis (LN) patients' monocyte chemotactic protein 
      1 (MCP-1) and urinary IP-10 (ulP-10) levels, the correlation between each 
      clinical activity index and rheumatism syndrome, thereby proving objective 
      evidence for microscopic typing of rheumatism syndrome. METHODS: Totally 60 LN 
      patients were assigned to the rheumatism group (31 cases) and the non-rheumatism 
      group (29 cases). Besides, 20 healthy volunteers were recruited as the normal 
      control group. Clinical data and renal pathology were collected, and urinary 
      levels of MCP-1 and IP-10 detected by ELISA. The correlation between rheumatism 
      syndrome and each activity index as well as manifestations of clinical activities 
      was comprehensively analyzed. Results (1) Patients in the rheumatism group were 
      more liable to occur fever, serositis, edema, and hypertension (P<0.05). (2) 
      Compared with the non-rheumatism group, patients in the rheumatism group 
      exhibited much higher levels of 24 h protein quantification and blood urea 
      nitrogen, higher levels of uMCP-1 and ulP-10. Microscopic hematuria, anti-ds-DNA, 
      anti-Sm, the positive rate of AnuA, scores of SLEDAI and BILAG were higher in the 
      rheumatism group than in the non-rheumatism group (P<0.05). Levels of plasma 
      albumin and complement C3 were lower in the rheumatism group than in the 
      non-rheumatism group (P<0.05). (3) The average activity index (AI) of the renal 
      pathology was higher in the rheumatism group than in the non-rheumatism group. 
      The most frequent pathological type of rheumatism group was type IV of LN. 
      CONCLUSIONS: More severe renal damage and immune abnormality occurred in LN 
      patients of rheumatism syndrome. Rheumatism syndrome is closely correlated to 
      clinical activity indices.
FAU - Yan, Xiao-qian
AU  - Yan XQ
FAU - Lu, Ying
AU  - Lu Y
FAU - Lin, Jing-lian
AU  - Lin JL
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Chemokine CCL2)
RN  - 0 (Complement C3)
SB  - IM
MH  - Biomedical Research
MH  - Chemokine CCL2/metabolism
MH  - Complement C3/metabolism
MH  - Hematuria
MH  - Humans
MH  - Kidney
MH  - Lupus Nephritis/*epidemiology/metabolism
MH  - Rheumatic Diseases/*epidemiology/metabolism
EDAT- 2015/04/18 06:00
MHDA- 2015/09/02 06:00
CRDT- 2015/04/18 06:00
PHST- 2015/04/18 06:00 [entrez]
PHST- 2015/04/18 06:00 [pubmed]
PHST- 2015/09/02 06:00 [medline]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2015 Feb;35(2):147-50.