PMID- 25881701
OWN - NLM
STAT- MEDLINE
DCOM- 20150618
LR  - 20230711
IS  - 0253-9772 (Print)
IS  - 0253-9772 (Linking)
VI  - 37
IP  - 4
DP  - 2015 Apr
TI  - [IGHMBP2 overexpression promotes cell migration and invasion in esophageal 
      squamous carcinoma].
PG  - 360-366
LID - 10.16288/j.yczz.14-371 [doi]
AB  - Immunoglobulin mu binding protein 2 (IGHMBP2) is located in 11q13.2, which is 
      frequently amplified in esophageal squamous cell carcinoma (ESCC). IGHMBP2 
      encodes a helicase involved in DNA replication and repair. IGHMBP2 protein also 
      regulates gene transcription. The present study aims to explore the amplification 
      of IGHMBP2 and its potential role in ESCC. A further analysis of our previously 
      reported array-CGH data showed that IGHMBP2 was amplified in 28.9% of primary 
      ESCC tumors. Fluorescence in situ hybridization (FISH) and Western blot showed 
      that IGHMBP2 was amplified and overexpressed in KYSE30, KYSE180, KYSE510 and 
      KYSE150 esophageal cancer cell lines. Transwell assays demonstrated that 
      knockdown of IGHMBP2 in KYSE30 and KYSE150 inhibited cell invasion and migration, 
      and increased the expression levels of E-cadherin. When rescue plasmids 
      expressing IGHMBP2 were introduced, the abilities of cell invasion and migration 
      were restored. These data suggest that IGHMBP2 overexpression may promote 
      invasion and migration of ESCC cells through down-regulation of E-cadherin.
FAU - Wang, Chun-Li
AU  - Wang CL
AD  - Department of Histology and Embryology, Anhui Medical University, Hefei 230032, 
      China.
FAU - Hao, Jia-Jie
AU  - Hao JJ
AD  - State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking 
      Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, 
      China.
FAU - Wu, Li-Fei
AU  - Wu LF
AD  - Department of Gastroenterology, Anqing Municipal Hospital of Anhui Medical 
      University, Anqing 246000, China.
FAU - Pan, Bei-Qing
AU  - Pan BQ
AD  - State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking 
      Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, 
      China.
FAU - Xu, Xin
AU  - Xu X
AD  - State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking 
      Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, 
      China.
FAU - Cai, Yan
AU  - Cai Y
AD  - State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking 
      Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, 
      China.
FAU - Wang, Ming-Rong
AU  - Wang MR
AD  - State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking 
      Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, 
      China.
FAU - Jia, Xue-Mei
AU  - Jia XM
AD  - Department of Histology and Embryology, Anhui Medical University, Hefei 230032, 
      China.
LA  - chi
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Yi Chuan
JT  - Yi chuan = Hereditas
JID - 9436478
RN  - 0 (Cadherins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (IGHMBP2 protein, human)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Cadherins/genetics/metabolism
MH  - Carcinoma, Squamous Cell/*genetics/metabolism/pathology/physiopathology
MH  - Cell Line, Tumor
MH  - *Cell Movement
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Esophageal Neoplasms/*genetics/metabolism/pathology/physiopathology
MH  - Esophageal Squamous Cell Carcinoma
MH  - Humans
MH  - Neoplasm Invasiveness
MH  - Signal Transduction
MH  - Transcription Factors/*genetics/metabolism
EDAT- 2015/04/18 06:00
MHDA- 2015/06/19 06:00
CRDT- 2015/04/18 06:00
PHST- 2015/04/18 06:00 [entrez]
PHST- 2015/04/18 06:00 [pubmed]
PHST- 2015/06/19 06:00 [medline]
AID - 2015-4-360 [pii]
AID - 10.16288/j.yczz.14-371 [doi]
PST - ppublish
SO  - Yi Chuan. 2015 Apr;37(4):360-366. doi: 10.16288/j.yczz.14-371.