PMID- 25882014
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20150513
IS  - 1873-3476 (Electronic)
IS  - 0378-5173 (Linking)
VI  - 487
IP  - 1-2
DP  - 2015 Jun 20
TI  - Propranolol hydrochloride-loaded liposomal gel for transdermal delivery: 
      Characterization and in vivo evaluation.
PG  - 135-41
LID - S0378-5173(15)00331-2 [pii]
LID - 10.1016/j.ijpharm.2015.04.023 [doi]
AB  - This study was to develop propranolol hydrochloride (PRO)-loaded liposomal gel as 
      a topical drug delivery system. Scanning electron microscope (SEM) revealed that 
      the liposomes were spherical and scattered in the surface of the gel. 
      Pseudoplastic flows of PRO liposomal gel were showed after stored at three 
      different temperatures. Besides, PRO liposomal gel showed non-irritating to the 
      skin of rabbit. Skin deposition studies in vivo demonstrated that PRO liposomal 
      gel can apparently increase drug content in skin compared with PRO gel. 
      Histopathology examination showed that PRO liposomal gel could obviously weaken 
      the barrier function of stratum corneum (SC) by comparison with PRO gel. What is 
      more, the plasma pharmacokinetic showed the maximum concentration in plasma was 
      0.41 mug/mL and 1.17 mug/mL after topical and oral administration respectively. 
      However, tissue distribution study showed PRO liposomal gel obviously changed 
      drug distribution in tissues, significantly increased drug concentration in skin 
      with about 74 folds compared with PRO gel. In conclusion, liposomes-based gel 
      could be a promising vehicle as a transdermal delivery system of PRO.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Guan, Yuanyuan
AU  - Guan Y
AD  - School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
FAU - Zuo, Tiantian
AU  - Zuo T
AD  - School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
FAU - Chang, Minglu
AU  - Chang M
AD  - School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
FAU - Zhang, Fang
AU  - Zhang F
AD  - School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
FAU - Wei, Ting
AU  - Wei T
AD  - School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
FAU - Shao, Wei
AU  - Shao W
AD  - School of Pharmaceutical Science, Shandong University, Jinan 250012, China.
FAU - Lin, Guimei
AU  - Lin G
AD  - School of Pharmaceutical Science, Shandong University, Jinan 250012, China. 
      Electronic address: guimeilin@sdu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150413
PL  - Netherlands
TA  - Int J Pharm
JT  - International journal of pharmaceutics
JID - 7804127
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Gels)
RN  - 0 (Irritants)
RN  - 0 (Liposomes)
RN  - 9Y8NXQ24VQ (Propranolol)
SB  - IM
MH  - Administration, Cutaneous
MH  - Adrenergic beta-Antagonists/*administration & dosage/adverse 
      effects/pharmacokinetics
MH  - Animals
MH  - Dermatitis, Irritant/pathology
MH  - Drug Delivery Systems
MH  - Gels
MH  - Irritants
MH  - Liposomes/*chemistry
MH  - Particle Size
MH  - Propranolol/*administration & dosage/adverse effects/pharmacokinetics
MH  - Rabbits
MH  - Rheology
MH  - Skin/drug effects/pathology
OTO - NOTNLM
OT  - Liposomal gel
OT  - Pharmacokinetic
OT  - Propranolol hydrochloride
OT  - Tissue distribution
OT  - Transdermal delivery
EDAT- 2015/04/18 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/04/18 06:00
PHST- 2015/01/24 00:00 [received]
PHST- 2015/04/10 00:00 [accepted]
PHST- 2015/04/18 06:00 [entrez]
PHST- 2015/04/18 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - S0378-5173(15)00331-2 [pii]
AID - 10.1016/j.ijpharm.2015.04.023 [doi]
PST - ppublish
SO  - Int J Pharm. 2015 Jun 20;487(1-2):135-41. doi: 10.1016/j.ijpharm.2015.04.023. 
      Epub 2015 Apr 13.