PMID- 25882700
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20220317
IS  - 1476-5551 (Electronic)
IS  - 0887-6924 (Linking)
VI  - 29
IP  - 9
DP  - 2015 Sep
TI  - Comparison of outcomes after unrelated cord blood and unmanipulated 
      haploidentical stem cell transplantation in adults with acute leukemia.
PG  - 1891-900
LID - 10.1038/leu.2015.98 [doi]
AB  - Outcomes after unmanipulated haploidentical stem cell transplantation (Haplo) and 
      after unrelated cord blood transplantation (UCBT) are encouraging and have become 
      alternative options to treat patients with high-risk acute leukemia without human 
      leukocyte antigen (HLA) matched donor. We compared outcomes after UCBT and Haplo 
      in adults with de novo acute myeloid leukemia (AML) and acute lymphoblastic 
      leukemia (ALL). Median follow-up was 24 months. Analysis was performed separately 
      for patients with AML, n=918 (Haplo=360, UCBT=558) and ALL, n=528 (Haplo=158 and 
      UCBT=370). UCBT was associated with delayed engraftment and higher graft failure 
      in both AML and ALL recipients. In multivariate analysis, UCBT was associated 
      with lower incidence of chronic graft-vs-host disease both in the AML group 
      (hazard ratio (HR)=0.63, P=0.008) and in the ALL group (HR=0.58, P=0.01). Not 
      statistically significant differences were observed between Haplo and UCBT for 
      relapse incidence (HR=0.95, P=0.76 for AML and HR=0.82, P=0.31 for ALL), 
      non-relapse mortality (HR=1.16, P=0.47 for AML and HR=1.23, P=0.23 for ALL) and 
      leukemia-free survival (HR 0.78, P=0.78 for AML and HR=1.00, P=0.84 for ALL). 
      There were no statistically differences on main outcomes after unmanipulated 
      Haplo and UCBT, and both approaches are valid for acute leukemia patients lacking 
      a HLA matched donor. Both strategies expand the donor pool for patients in need.
FAU - Ruggeri, A
AU  - Ruggeri A
AD  - Hopital Saint Antoine, Service d'Hematologie et Therapie Cellulaire, AP-HP, 
      Paris, France.
AD  - INSERM, UMRs 938, Paris, France.
AD  - Hopital Saint Louis, Eurocord, IUH University Paris VII, Paris, France.
FAU - Labopin, M
AU  - Labopin M
AD  - Hopital Saint Antoine, Service d'Hematologie et Therapie Cellulaire, AP-HP, 
      Paris, France.
AD  - Hopital Saint Antoine, Universite Pierre and Marie Curie, Paris, France.
FAU - Sanz, G
AU  - Sanz G
AD  - Hospital Universitario y Politecnico La Fe, Valencia, Spain.
FAU - Piemontese, S
AU  - Piemontese S
AD  - Hematology and BMT Unit, San Raffaele Scientific Institute, Milano, Italy.
FAU - Arcese, W
AU  - Arcese W
AD  - Rome Transplant Network, University Tor Vergata, Rome, Italy.
FAU - Bacigalupo, A
AU  - Bacigalupo A
AD  - Dipartimento di Ematologia, Ospedale San Martino, Genova, Italy.
FAU - Blaise, D
AU  - Blaise D
AD  - Institut Paoli Calmettes, Marseille, France.
FAU - Bosi, A
AU  - Bosi A
AD  - Careggi University Hospital, Firenze, Italy.
FAU - Huang, H
AU  - Huang H
AD  - Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang 
      University School of Medicine, Hangzhou, China.
FAU - Karakasis, D
AU  - Karakasis D
AD  - Evangelismos Hospital, Division of Hematology, BMT Unit, Athens, Greece.
FAU - Koc, Y
AU  - Koc Y
AD  - Stem Cell Transplant Unit, Medical Park, Antalya, Turkey.
FAU - Michallet, M
AU  - Michallet M
AD  - Hopital Edouard Herriot, Lyon, France.
FAU - Picardi, A
AU  - Picardi A
AD  - Rome Transplant Network, University Tor Vergata, Rome, Italy.
FAU - Sanz, J
AU  - Sanz J
AD  - Hospital Universitario y Politecnico La Fe, Valencia, Spain.
FAU - Santarone, S
AU  - Santarone S
AD  - Ospedale Civile, Dipartimento di Ematologia, BMT Unit, Pescara, Italy.
FAU - Sengelov, H
AU  - Sengelov H
AD  - Rigshospitalet, Copenhagen, Denmark.
FAU - Sierra, J
AU  - Sierra J
AD  - Hospital Santa Creu i Sant Pau, Jose Carreras Institute, Universitat Autonoma de 
      Barcelona, Barcelona, Spain.
FAU - Vincent, L
AU  - Vincent L
AUID- ORCID: 0000-0001-5904-1286
AD  - CHU Montpellier, Montpellier, France.
FAU - Volt, F
AU  - Volt F
AD  - Hopital Saint Louis, Eurocord, IUH University Paris VII, Paris, France.
FAU - Nagler, A
AU  - Nagler A
AD  - Chaim Sheba Medical Center, Tel-Hashomer, Israel.
AD  - ALWP Office Hopital Saint Antoine, Service d'Hematologie et Therapie Cellulaire, 
      AP-HP, Paris, France.
FAU - Gluckman, E
AU  - Gluckman E
AD  - Hopital Saint Louis, Eurocord, IUH University Paris VII, Paris, France.
AD  - Monacord, Centre Scientifique de Monaco, Monaco, France.
FAU - Ciceri, F
AU  - Ciceri F
AD  - Hematology and BMT Unit, San Raffaele Scientific Institute, Milano, Italy.
FAU - Rocha, V
AU  - Rocha V
AD  - Hopital Saint Louis, Eurocord, IUH University Paris VII, Paris, France.
AD  - Churchill Hospital, Oxford University, Oxford, UK.
FAU - Mohty, M
AU  - Mohty M
AD  - Hopital Saint Antoine, Service d'Hematologie et Therapie Cellulaire, AP-HP, 
      Paris, France.
AD  - INSERM, UMRs 938, Paris, France.
AD  - Hopital Saint Antoine, Universite Pierre and Marie Curie, Paris, France.
CN  - Eurocord, Cord Blood Committee of Cellular Therapy and Immunobiology working 
      party-EBMT
CN  - ALWP-EBMT study
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150417
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - *Cord Blood Stem Cell Transplantation
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Survival
MH  - Graft vs Host Disease/etiology/prevention & control
MH  - HLA Antigens/*immunology
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Histocompatibility Testing
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*immunology/mortality/*therapy
MH  - Male
MH  - Middle Aged
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*immunology/mortality/*therapy
MH  - Recurrence
MH  - Risk Factors
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2015/04/18 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/04/18 06:00
PHST- 2014/11/03 00:00 [received]
PHST- 2015/04/01 00:00 [revised]
PHST- 2015/04/07 00:00 [accepted]
PHST- 2015/04/18 06:00 [entrez]
PHST- 2015/04/18 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - leu201598 [pii]
AID - 10.1038/leu.2015.98 [doi]
PST - ppublish
SO  - Leukemia. 2015 Sep;29(9):1891-900. doi: 10.1038/leu.2015.98. Epub 2015 Apr 17.