PMID- 25883426
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150417
LR  - 20240322
IS  - 0970-1915 (Print)
IS  - 0974-0422 (Electronic)
IS  - 0970-1915 (Linking)
VI  - 30
IP  - 2
DP  - 2015 Apr
TI  - Efficacy of Turmeric as Adjuvant Therapy in Type 2 Diabetic Patients.
PG  - 180-6
LID - 10.1007/s12291-014-0436-2 [doi]
AB  - It is known that there is a significant interplay of insulin resistance, 
      oxidative stress, dyslipidemia, and inflammation in type 2 diabetes mellitus 
      (T2DM). The study was undertaken to investigate the effect of turmeric as an 
      adjuvant to anti-diabetic therapy. Sixty diabetic subjects on metformin therapy 
      were recruited and randomized into two groups (30 each). Group I received 
      standard metformin treatment while group II was on standard metformin therapy 
      with turmeric (2 g) supplements for 4 weeks. The biochemical parameters were 
      assessed at the time of recruitment for study and after 4 weeks of treatment. 
      Turmeric supplementation in metformin treated type 2 diabetic patient 
      significantly decreased fasting glucose (95 +/- 11.4 mg/dl, P < 0.001) and HbA1c 
      levels (7.4 +/- 0.9 %, P < 0.05). Turmeric administered group showed reduction in 
      lipid peroxidation, MDA (0.51 +/- 0.11 micromol/l, P < 0.05) and enhanced total 
      antioxidant status (511 +/- 70 micromol/l, P < 0.05). Turmeric also exhibited 
      beneficial effects on dyslipidemia LDL cholesterol (113.2 +/- 15.3 mg/dl, 
      P < 0.01), non HDL cholesterol (138.3 +/- 12.1 mg/dl, P < 0.05) and LDL/HDL ratio 
      (3.01 +/- 0.61, P < 0.01) and reduced inflammatory marker, hsCRP (3.4 +/- 2.0 mg/dl, 
      P < 0.05). Turmeric supplementation as an adjuvant to T2DM on metformin treatment 
      had a beneficial effect on blood glucose, oxidative stress and inflammation.
FAU - Maithili Karpaga Selvi, N
AU  - Maithili Karpaga Selvi N
AD  - Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Pondicherry, 605 006 India.
FAU - Sridhar, M G
AU  - Sridhar MG
AD  - Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Pondicherry, 605 006 India.
FAU - Swaminathan, R P
AU  - Swaminathan RP
AD  - Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education 
      and Research, Pondicherry, 605 006 India.
FAU - Sripradha, R
AU  - Sripradha R
AD  - Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Pondicherry, 605 006 India.
LA  - eng
PT  - Journal Article
DEP - 20140508
PL  - India
TA  - Indian J Clin Biochem
JT  - Indian journal of clinical biochemistry : IJCB
JID - 8708303
PMC - PMC4393385
OTO - NOTNLM
OT  - Diabetes
OT  - Dyslipidemia
OT  - Inflammation
OT  - Malondialdehyde
OT  - Metformin
OT  - Turmeric
EDAT- 2015/04/18 06:00
MHDA- 2015/04/18 06:01
PMCR- 2016/04/01
CRDT- 2015/04/18 06:00
PHST- 2013/11/23 00:00 [received]
PHST- 2014/04/15 00:00 [accepted]
PHST- 2015/04/18 06:00 [entrez]
PHST- 2015/04/18 06:00 [pubmed]
PHST- 2015/04/18 06:01 [medline]
PHST- 2016/04/01 00:00 [pmc-release]
AID - 436 [pii]
AID - 10.1007/s12291-014-0436-2 [doi]
PST - ppublish
SO  - Indian J Clin Biochem. 2015 Apr;30(2):180-6. doi: 10.1007/s12291-014-0436-2. Epub 
      2014 May 8.