PMID- 25884493
OWN - NLM
STAT- MEDLINE
DCOM- 20160115
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 4
DP  - 2015
TI  - Association of the FAM46A gene VNTRs and BAG6 rs3117582 SNP with non small cell 
      lung cancer (NSCLC) in Croatian and Norwegian populations.
PG  - e0122651
LID - 10.1371/journal.pone.0122651 [doi]
LID - e0122651
AB  - We analyzed for associations between a variable number of tandem repeat (VNTR) 
      polymorphism in the Family with sequence similarity 46, member A (FAM46A) gene 
      and a single nucleotide polymorphism (rs3117582) in the BCL2-Associated 
      Athanogene 6 (BAG6) with non small cell lung cancer in Croatian and Norwegian 
      subjects. A total of 503 (262 Croatian and 241Norwegian) non small cell lung 
      cancer patients and 897 controls (568 Croatian and 329 Norwegian) were analyzed. 
      We found that the frequency of allele b (three VNTR repeats) of FAM46A gene was 
      significantly increased in the patients compared to the healthy controls in the 
      Croatian and the combined Croatian and Norwegian subjects. Genotype frequencies 
      of cd (four and five VNTR repeats) and cc (four VNTR repeats homozygote) of the 
      FAM46A gene were significantly decreased in the patients compared to the healthy 
      controls in the Croatian and Norwegian subjects, respectively. Logistic 
      regression analyses revealed FAM46A genotype cc to be an independent predictive 
      factor for non small cell lung cancer risk in the Norwegian subjects after 
      adjustment for age, gender and smoking status. This is the first study to suggest 
      an association between the FAM46A gene VNTR polymorphisms and non small cell lung 
      cancer. We found also that BAG6 rs3117582 SNP was associated with non small cell 
      lung cancer in the Norwegian subjects and the combined Croatian-Norwegian 
      subjects corroborating the earlier finding that BAG6 rs3117582 SNP was associated 
      with lung cancer in Europeans. Logistic regression analyses revealed that 
      genotypes and alleles of BAG6 were independent predictive factor for non small 
      cell lung cancer risk in the Norwegian and combined Croatian-Norwegian subjects, 
      after adjustment for age and gender.
FAU - Etokebe, Godfrey Essien
AU  - Etokebe GE
AD  - Institute for Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, 
      Norway.
FAU - Zienolddiny, Shanbeh
AU  - Zienolddiny S
AD  - Department of Chemical and Biological Working Environment, National Institute of 
      Occupational Health, Oslo, Norway.
FAU - Kupanovac, Zeljko
AU  - Kupanovac Z
AD  - Institute for Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, 
      Norway; Section of Pulmology, Department of Internal Medicine, Clinical Hospital 
      Center, University of Rijeka, Rijeka, Croatia.
FAU - Enersen, Morten
AU  - Enersen M
AD  - Institute for Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, 
      Norway.
FAU - Balen, Sanja
AU  - Balen S
AD  - Institute for Transfusion Medicine, Clinical Hospital Center, University of 
      Rijeka, Rijeka, Croatia.
FAU - Flego, Veljko
AU  - Flego V
AD  - Section of Pulmology, Department of Internal Medicine, Clinical Hospital Center, 
      University of Rijeka, Rijeka, Croatia.
FAU - Bulat-Kardum, Ljiljana
AU  - Bulat-Kardum L
AD  - Section of Pulmology, Department of Internal Medicine, Clinical Hospital Center, 
      University of Rijeka, Rijeka, Croatia.
FAU - Radojcic-Badovinac, Andelka
AU  - Radojcic-Badovinac A
AD  - Department for Biology and Medical Genetics, Faculty of Medicine, University of 
      Rijeka, Rijeka, Croatia.
FAU - Skaug, Vidar
AU  - Skaug V
AD  - Department of Chemical and Biological Working Environment, National Institute of 
      Occupational Health, Oslo, Norway.
FAU - Bakke, Per
AU  - Bakke P
AD  - Department of Clinical Sciences, University of Bergen, Bergen, Norway.
FAU - Haugen, Aage
AU  - Haugen A
AD  - Department of Chemical and Biological Working Environment, National Institute of 
      Occupational Health, Oslo, Norway.
FAU - Dembic, Zlatko
AU  - Dembic Z
AD  - Institute for Oral Biology, Faculty of Dentistry, University of Oslo, Oslo, 
      Norway.
LA  - eng
PT  - Journal Article
DEP - 20150417
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (BAG6 protein, human)
RN  - 0 (Molecular Chaperones)
RN  - 0 (Proteins)
RN  - 9007-49-2 (DNA)
RN  - EC 2.7.7.19 (Polynucleotide Adenylyltransferase)
RN  - EC 2.7.7.19 (TENT5A protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Carcinoma, Non-Small-Cell Lung/*genetics/pathology
MH  - Croatia
MH  - DNA/analysis
MH  - Electrophoresis, Capillary
MH  - Female
MH  - Gene Frequency
MH  - Genome, Human
MH  - Genotype
MH  - Humans
MH  - Lung Neoplasms/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Minisatellite Repeats/genetics
MH  - Molecular Chaperones/*genetics
MH  - Norway
MH  - Polymorphism, Single Nucleotide
MH  - Polynucleotide Adenylyltransferase
MH  - Proteins/*genetics
MH  - Sequence Analysis, DNA
MH  - Smoking
MH  - White People/*genetics
PMC - PMC4401550
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/04/18 06:00
MHDA- 2016/01/16 06:00
PMCR- 2015/04/17
CRDT- 2015/04/18 06:00
PHST- 2014/11/22 00:00 [received]
PHST- 2015/02/11 00:00 [accepted]
PHST- 2015/04/18 06:00 [entrez]
PHST- 2015/04/18 06:00 [pubmed]
PHST- 2016/01/16 06:00 [medline]
PHST- 2015/04/17 00:00 [pmc-release]
AID - PONE-D-14-52558 [pii]
AID - 10.1371/journal.pone.0122651 [doi]
PST - epublish
SO  - PLoS One. 2015 Apr 17;10(4):e0122651. doi: 10.1371/journal.pone.0122651. 
      eCollection 2015.