PMID- 25884594
OWN - NLM
STAT- MEDLINE
DCOM- 20161005
LR  - 20240513
IS  - 1472-6831 (Electronic)
IS  - 1472-6831 (Linking)
VI  - 15
DP  - 2015 Mar 24
TI  - Pathological periodontal pockets are associated with raised diastolic blood 
      pressure in obese adolescents.
PG  - 41
LID - 10.1186/s12903-015-0026-6 [doi]
LID - 41
AB  - BACKGROUND: Obesity, a well-known risk factor for developing cardiovascular 
      disease (CVD), is associated with chronic periodontitis in adults. This 
      cross-sectional pilot study on obese adolescents was designed to investigate 
      whether periodontal disease in terms of pathological periodontal pockets is 
      associated with raised blood pressure and other risk markers for CVD. METHODS: 
      The study included 75 obese subjects between 12 to 18 years of age, mean 14.5. 
      Subjects answered a questionnaire regarding health, oral hygiene habits and 
      sociodemographic factors. A clinical examination included Visible Plaque Index 
      (VPI %), Gingival inflammation (BOP %) and the occurrence of pathological pockets 
      exceeding 4 mm (PD >/= 4 mm). Blood serum were collected and analyzed. The systolic 
      and diastolic blood pressures were registered. RESULTS: Adolescents with 
      pathological periodontal pockets (PD >/= 4 mm; n = 14) had significantly higher BOP 
      >25% (P = 0.002), higher diastolic blood pressure (P = 0.008), higher levels of 
      Interleukin (IL)-6 (P < 0.001), Leptin (P = 0.018), Macrophage Chemoattractant 
      Protein-1 (MCP-1) (P = 0.049) and thyroid stimulating hormone (TSH) (P = 0.004) 
      in blood serum compared with subjects without pathological periodontal pockets 
      (PD >/= 4 mm; n = 61). The bivariate linear regression analysis demonstrated that 
      PD >/= 4 mm (P = 0.008) and systolic blood pressure (P < 0.001) were significantly 
      associated with the dependent variable "diastolic blood pressure". The 
      association between PD >/= 4 mm and diastolic blood pressure remained significant 
      (P = 0.006) even after adjusting for potential confounders BMI-sds, age, gender, 
      mother's country of birth, BOP >25%, IL-6, IL-8, Leptin, MCP-1, TSH and total 
      cholesterol in the multiple regression analysis. CONCLUSION: In conclusion, this 
      study indicates an association between pathological periodontal pockets and 
      diastolic blood pressure in obese adolescents. The association was unaffected by 
      other risk markers for cardiovascular events or periodontal disease. The results 
      call for collaboration between pediatric dentists and medical physicians in 
      preventing obesity development and its associated disorders.
FAU - Zeigler, Cecilia C
AU  - Zeigler CC
AD  - Division of Pediatric Dentistry, Department of Dental Medicine, Karolinska 
      Institutet, Box 4064, SE-141 04, Huddinge, Stockholm, Sweden. 
      Cecilia.Zeigler@ki.se.
FAU - Wondimu, Biniyam
AU  - Wondimu B
AD  - Division of Pediatric Dentistry, Department of Dental Medicine, Karolinska 
      Institutet, Box 4064, SE-141 04, Huddinge, Stockholm, Sweden. 
      Biniyam.Wondimu@ki.se.
FAU - Marcus, Claude
AU  - Marcus C
AD  - National Childhood Obesity Centre, Division of Pediatrics Department of Clinical 
      Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. 
      Claude.Marcus@ki.se.
FAU - Modeer, Thomas
AU  - Modeer T
AD  - Division of Pediatric Dentistry, Department of Dental Medicine, Karolinska 
      Institutet, Box 4064, SE-141 04, Huddinge, Stockholm, Sweden. 
      Thomas.Modeer@ki.se.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150324
PL  - England
TA  - BMC Oral Health
JT  - BMC oral health
JID - 101088684
RN  - 0 (CCL2 protein, human)
RN  - 0 (CXCL8 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (IL6 protein, human)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Leptin)
RN  - 9002-71-5 (Thyrotropin)
SB  - IM
MH  - Adolescent
MH  - Age Factors
MH  - Body Mass Index
MH  - Chemokine CCL2/blood
MH  - Child
MH  - Cross-Sectional Studies
MH  - Dental Plaque Index
MH  - Diastole
MH  - Female
MH  - Humans
MH  - Hypertension/blood/*complications
MH  - Interleukin-6/blood
MH  - Interleukin-8/blood
MH  - Leptin/blood
MH  - Male
MH  - Obesity/blood/*complications
MH  - Periodontal Index
MH  - Periodontal Pocket/blood/*complications
MH  - Pilot Projects
MH  - Sex Factors
MH  - Systole
MH  - Thyrotropin/blood
PMC - PMC4373518
EDAT- 2015/04/18 06:00
MHDA- 2016/10/07 06:00
PMCR- 2015/03/24
CRDT- 2015/04/18 06:00
PHST- 2015/01/26 00:00 [received]
PHST- 2015/03/10 00:00 [accepted]
PHST- 2015/04/18 06:00 [entrez]
PHST- 2015/04/18 06:00 [pubmed]
PHST- 2016/10/07 06:00 [medline]
PHST- 2015/03/24 00:00 [pmc-release]
AID - 10.1186/s12903-015-0026-6 [pii]
AID - 26 [pii]
AID - 10.1186/s12903-015-0026-6 [doi]
PST - epublish
SO  - BMC Oral Health. 2015 Mar 24;15:41. doi: 10.1186/s12903-015-0026-6.