PMID- 25884913
OWN - NLM
STAT- MEDLINE
DCOM- 20160303
LR  - 20231111
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Print)
IS  - 2042-6976 (Linking)
VI  - 5
IP  - 6
DP  - 2015 Jun
TI  - Allergic sensitization, rhinitis, and tobacco smoke exposure in U.S. children and 
      adolescents.
PG  - 471-6
LID - 10.1002/alr.21444 [doi]
AB  - BACKGROUND: Childhood tobacco exposure has been linked with sinonasal pathology, 
      and may be associated with allergic sensitization. This study evaluates the 
      association between exposure to active smoking or secondhand smoke (SHS) and the 
      prevalence of rhinitis and allergic sensitization in the U.S. pediatric 
      population. METHODS: Cross-sectional study in 2714 children and adolescents aged 
      6 to 19 in the National Health and Nutrition Examination Survey (NHANES), 
      2005-2006. Active smoking was defined as self-reported smoking or serum cotinine 
      concentrations >10 ng/mL. SHS was defined as nonactive smokers who reported 
      living with >/=1 smokers or had serum cotinine >/=0.011 ng/mL. Self-reported rhinitis 
      was based on symptoms during the past 12 months, and allergen sensitization was 
      defined as a positive response to any of the 19 specific immunoglobulin E (IgE) 
      antigens tested. RESULTS: About half of the population (54%) had detectable 
      levels of IgE specific to at least 1 of the tested allergens, and 25% reported a 
      history of rhinitis. After multivariate adjustment, an increased prevalence rate 
      ratio (PRR) of self-reported rhinitis was seen in individuals in the highest 
      cotinine tertile among active smokers (PRR, 1.73; 95% confidence interval [CI], 
      1.23 to 2.43), with a significant trend between increasing cotinine levels in 
      individuals exposed to either secondhand smoke or active smoking (p = 0.05 for 
      both analyses). Significantly less food allergen sensitization was observed in 
      participants in the highest cotinine tertile of secondhand smoke (PRR, 0.61; 95% 
      CI, 0.43 to 0.85). CONCLUSION: Tobacco smoke exposure was associated with 
      increased prevalence of rhinitis symptoms, but decreased prevalence of allergic 
      sensitization. The results highlight the complex relationship between tobacco 
      exposure and sinonasal pathology.
CI  - (c) 2015 ARS-AAOA, LLC.
FAU - Shargorodsky, Josef
AU  - Shargorodsky J
AD  - Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University 
      School of Medicine, Baltimore, MD.
FAU - Garcia-Esquinas, Esther
AU  - Garcia-Esquinas E
AD  - Department of Preventive Medicine and Public Health, School of Medicine, Autonoma 
      University, Madrid, Spain.
AD  - Ciber of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
FAU - Navas-Acien, Ana
AU  - Navas-Acien A
AD  - Department of Environmental Health Sciences, Johns Hopkins University Bloomberg 
      School of Public Health, Baltimore, MD.
AD  - Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins 
      Medical Institutions, Baltimore, MD.
FAU - Lin, Sandra Y
AU  - Lin SY
AD  - Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University 
      School of Medicine, Baltimore, MD.
LA  - eng
GR  - P30 CA006973/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20150417
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 0 (Allergens)
RN  - 0 (Tobacco Smoke Pollution)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - K5161X06LL (Cotinine)
SB  - IM
EIN - Int Forum Allergy Rhinol. 2015 Aug;5(8):768. PMID: 26238102
MH  - Adolescent
MH  - Allergens/*immunology
MH  - Child
MH  - Cotinine/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*epidemiology/immunology
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Nutrition Surveys
MH  - Prevalence
MH  - Rhinitis, Allergic/*epidemiology/immunology
MH  - Smoking/*adverse effects
MH  - Tobacco Smoke Pollution/*adverse effects
MH  - Young Adult
PMC - PMC4763876
MID - NIHMS756474
OTO - NOTNLM
OT  - allergy
OT  - children
OT  - rhinitis
OT  - smoking
OT  - tobacco
COIS- Potential conflict of interest: None provided.
EDAT- 2015/04/18 06:00
MHDA- 2016/03/05 06:00
PMCR- 2016/02/23
CRDT- 2015/04/18 06:00
PHST- 2014/04/15 00:00 [received]
PHST- 2014/07/24 00:00 [revised]
PHST- 2014/09/12 00:00 [accepted]
PHST- 2015/04/18 06:00 [entrez]
PHST- 2015/04/18 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
PHST- 2016/02/23 00:00 [pmc-release]
AID - 10.1002/alr.21444 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2015 Jun;5(6):471-6. doi: 10.1002/alr.21444. Epub 2015 
      Apr 17.