PMID- 25885038
OWN - NLM
STAT- MEDLINE
DCOM- 20151030
LR  - 20220311
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 15
DP  - 2015 Mar 4
TI  - Serum brain-derived neurotrophic factor levels and personality traits in patients 
      with major depression.
PG  - 33
LID - 10.1186/s12888-015-0413-1 [doi]
LID - 33
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is a member of the 
      neurotrophin family of growth factors. Previous studies have demonstrated lower 
      serum BDNF levels in patients with major depressive disorder (MDD) and reported 
      an association between BDNF levels and depression-related personality traits in 
      healthy subjects. The aim of the present study was to explore for a possible 
      association between peripheral BDNF levels and personality traits in patients 
      with MDD. METHODS: In this cross-sectional study, a total of 123 inpatients with 
      MDD (Diagnostic and Statistical Manual for Mental Disorders, 4th edition) at the 
      Juntendo University Koshigaya Hospital were recruited. Serum levels of BDNF were 
      measured. Personality traits were assessed using the 125-item short version of 
      the Temperament and Character Inventory (TCI). RESULTS: Multiple regression 
      analysis adjusted for age, sex, body mass index, dose of antidepressant, and 
      depression severity showed that TCI Self-Directedness (SD) scores were negatively 
      associated with serum BDNF levels (beta = -0.23, p = 0.026). CONCLUSIONS: MDD 
      patients who have low SD did not show the reduction in serum BDNF levels that is 
      normally associated with depressive state. Our findings suggest that 
      depression-related biological changes may not occur in these individuals.
FAU - Nomoto, Hiroshi
AU  - Nomoto H
AD  - Department of Psychiatry, Juntendo University, School of Medicine, 2-1-1 Hongo, 
      Tokyo, Bunkyo-ku, Japan. hnomoto@juntendo.ac.jp.
FAU - Baba, Hajime
AU  - Baba H
AD  - Department of Psychiatry, Juntendo University, School of Medicine, 2-1-1 Hongo, 
      Tokyo, Bunkyo-ku, Japan. hbaba@juntendo.ac.jp.
AD  - Juntendo University Mood Disorder Project (JUMP), Department of Psychiatry, 
      Juntendo University Koshigaya Hospital, 560 Fukuroyama, 343-0032, Koshigaya, 
      Saitama, Japan. hbaba@juntendo.ac.jp.
FAU - Satomura, Emi
AU  - Satomura E
AD  - Department of Psychiatry, Juntendo University, School of Medicine, 2-1-1 Hongo, 
      Tokyo, Bunkyo-ku, Japan. esatomu@juntendo.ac.jp.
FAU - Maeshima, Hitoshi
AU  - Maeshima H
AD  - Department of Psychiatry, Juntendo University, School of Medicine, 2-1-1 Hongo, 
      Tokyo, Bunkyo-ku, Japan. hitoshim@juntendo.ac.jp.
AD  - Juntendo University Mood Disorder Project (JUMP), Department of Psychiatry, 
      Juntendo University Koshigaya Hospital, 560 Fukuroyama, 343-0032, Koshigaya, 
      Saitama, Japan. hitoshim@juntendo.ac.jp.
FAU - Takebayashi, Naoko
AU  - Takebayashi N
AD  - Department of Psychiatry, Juntendo University, School of Medicine, 2-1-1 Hongo, 
      Tokyo, Bunkyo-ku, Japan. nuemura@juntendo.ac.jp.
AD  - Juntendo University Mood Disorder Project (JUMP), Department of Psychiatry, 
      Juntendo University Koshigaya Hospital, 560 Fukuroyama, 343-0032, Koshigaya, 
      Saitama, Japan. nuemura@juntendo.ac.jp.
FAU - Namekawa, Yuki
AU  - Namekawa Y
AD  - Department of Psychiatry, Juntendo University, School of Medicine, 2-1-1 Hongo, 
      Tokyo, Bunkyo-ku, Japan. yukia@juntendo.ac.jp.
AD  - Juntendo University Mood Disorder Project (JUMP), Department of Psychiatry, 
      Juntendo University Koshigaya Hospital, 560 Fukuroyama, 343-0032, Koshigaya, 
      Saitama, Japan. yukia@juntendo.ac.jp.
FAU - Suzuki, Toshihito
AU  - Suzuki T
AD  - Department of Psychiatry, Juntendo University, School of Medicine, 2-1-1 Hongo, 
      Tokyo, Bunkyo-ku, Japan. psuzukit@juntendo.ac.jp.
AD  - Juntendo University Mood Disorder Project (JUMP), Department of Psychiatry, 
      Juntendo University Koshigaya Hospital, 560 Fukuroyama, 343-0032, Koshigaya, 
      Saitama, Japan. psuzukit@juntendo.ac.jp.
FAU - Arai, Heii
AU  - Arai H
AD  - Department of Psychiatry, Juntendo University, School of Medicine, 2-1-1 Hongo, 
      Tokyo, Bunkyo-ku, Japan. heii@juntendo.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150304
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Character
MH  - Cross-Sectional Studies
MH  - *Depressive Disorder, Major/blood/diagnosis/drug therapy/psychology
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Personality/*physiology
MH  - Personality Inventory
MH  - Regression Analysis
MH  - Temperament/physiology
PMC - PMC4354762
EDAT- 2015/04/18 06:00
MHDA- 2015/10/31 06:00
PMCR- 2015/03/04
CRDT- 2015/04/18 06:00
PHST- 2014/08/01 00:00 [received]
PHST- 2015/02/19 00:00 [accepted]
PHST- 2015/04/18 06:00 [entrez]
PHST- 2015/04/18 06:00 [pubmed]
PHST- 2015/10/31 06:00 [medline]
PHST- 2015/03/04 00:00 [pmc-release]
AID - 10.1186/s12888-015-0413-1 [pii]
AID - 413 [pii]
AID - 10.1186/s12888-015-0413-1 [doi]
PST - epublish
SO  - BMC Psychiatry. 2015 Mar 4;15:33. doi: 10.1186/s12888-015-0413-1.