PMID- 25885721
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150418
LR  - 20220318
IS  - 0259-1162 (Print)
IS  - 2229-7685 (Electronic)
IS  - 2229-7685 (Linking)
VI  - 7
IP  - 1
DP  - 2013 Jan-Apr
TI  - Effect of tramadol on perioperative immune function in patients undergoing 
      gastric cancer surgeries.
PG  - 54-7
LID - 10.4103/0259-1162.113992 [doi]
AB  - BACKGROUND: A prospective randomized controlled trial was designed to observe the 
      effect of tramadol on T-lymphocyte subsets, activated T cell and natural killer 
      (NK) cells of patients undergoing gastric cancer surgeries. SUBJECTS AND METHODS: 
      Thirty patients undergoing elective gastric cancer surgeries under general 
      anesthesia were randomly divided into two groups. Before anesthesia induction, 
      Group I did not receive any drugs and Group II received intramuscular tramadol 1 
      mg/kg. Peripheral venous blood samples were taken before anesthesia, 1 h after 
      incision and postoperation. CD3(+), CD3(+) CD4(+), CD3(+) CD8(+), CD3(-)CD16(+) 
      CD56(+) (NK) cells and CD3(+) human leukocyte antigen (HLA)-DR(+) (activated T 
      cell) were measured by flow cytometer. RESULTS: One hour after incision, CD3(+), 
      CD3(+) CD4+, CD3(+) CD4(+)/CD3(+) CD8(+), CD3(-)CD16(+) CD56(+), and CD3(+) 
      HLA-DR(+) cells in the experimental and control group were significantly 
      decreased compared with their baselines (P < 0.05), while the values of Group I 
      were lower than those of Group II (P < 0.05). After surgery, the values of Group 
      I were lower than their baselines (P < 0.05). But the values of Group II had no 
      significant difference compared with their baselines. CONCLUSION: Tramadol can 
      reduce the decrease of T-lymphocytes subsets and NK cells, thus improve the 
      cellular immune function in the perioperation of gastric cancer.
FAU - Zhou, Li-Wen
AU  - Zhou LW
AD  - Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of 
      Arts and Science, Hubei Province, China.
FAU - Ding, Han-Lin
AU  - Ding HL
AD  - Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of 
      Arts and Science, Hubei Province, China.
FAU - Li, Ming-Qiang
AU  - Li MQ
AD  - Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of 
      Arts and Science, Hubei Province, China.
FAU - Jin, Sheng
AU  - Jin S
AD  - Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of 
      Arts and Science, Hubei Province, China.
FAU - Wang, Xue-Song
AU  - Wang XS
AD  - Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of 
      Arts and Science, Hubei Province, China.
FAU - Ji, Li-Juan
AU  - Ji LJ
AD  - Department of Anesthesiology, Xiangyang Central Hospital, Hubei University of 
      Arts and Science, Hubei Province, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Anesth Essays Res
JT  - Anesthesia, essays and researches
JID - 101578762
PMC - PMC4173499
OTO - NOTNLM
OT  - Gastric cancer
OT  - T-lymphocyte subsets
OT  - killer cells
OT  - natural
OT  - tramadol
COIS- Conflict of Interest: None declared.
EDAT- 2013/01/01 00:00
MHDA- 2013/01/01 00:01
PMCR- 2013/01/01
CRDT- 2015/04/18 06:00
PHST- 2015/04/18 06:00 [entrez]
PHST- 2013/01/01 00:00 [pubmed]
PHST- 2013/01/01 00:01 [medline]
PHST- 2013/01/01 00:00 [pmc-release]
AID - AER-7-54 [pii]
AID - 10.4103/0259-1162.113992 [doi]
PST - ppublish
SO  - Anesth Essays Res. 2013 Jan-Apr;7(1):54-7. doi: 10.4103/0259-1162.113992.