PMID- 25886523
OWN - NLM
STAT- MEDLINE
DCOM- 20151026
LR  - 20181202
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 15
DP  - 2015 Mar 10
TI  - Association of decreased serum brain-derived neurotrophic factor (BDNF) 
      concentrations in early pregnancy with antepartum depression.
PG  - 43
LID - 10.1186/s12888-015-0428-7 [doi]
LID - 43
AB  - BACKGROUND: Antepartum depression is one of the leading causes of maternal 
      morbidity and mortality in the prenatal period. There is accumulating evidence 
      for the role of brain-derived neurotrophic factor (BDNF) in the pathophysiology 
      of depression. The present study examines the extent to which maternal early 
      pregnancy serum BDNF levels are associated with antepartum depression. METHOD: A 
      total of 968 women were recruited and interviewed in early pregnancy. Antepartum 
      depression prevalence and symptom severity were assessed using the Patient Health 
      Questionnaire-9 (PHQ-9) scale. Maternal serum BDNF levels were measured using a 
      competitive enzyme-linked immunosorbent assay (ELISA). Logistic regression 
      procedures were performed to estimate odds ratios (OR) and 95% confidence 
      intervals (95% CI) adjusted for confounders. RESULTS: Maternal early pregnancy 
      serum BDNF levels were significantly lower in women with antepartum depression 
      compared to women without depression (mean +/- standard deviation [SD]: 
      20.78 +/- 5.97 vs. 21.85 +/- 6.42 ng/ml, p = 0.024). Lower BDNF levels were 
      associated with increased odds of maternal antepartum depression. After adjusting 
      for confounding, women whose serum BDNF levels were in the lowest three quartiles 
      (<17.32 ng/ml) had 1.61-fold increased odds (OR = 1.61, 95% CI: 1.13, 2.30) of 
      antepartum depression as compared with women whose BDNF levels were in the 
      highest quartile (>25.31 ng/ml). There was no evidence of an association of BDNF 
      levels with depression symptom severity. CONCLUSIONS: Lower maternal serum BDNF 
      levels in early pregnancy are associated with antepartum depression. These 
      findings may point toward new therapeutic opportunities and BDNF should be 
      assessed as a potential biomarker for risk prediction and monitoring response to 
      treatment for antepartum depression.
FAU - Fung, Jenny
AU  - Fung J
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      MA, USA. jennyfung@college.harvard.edu.
FAU - Gelaye, Bizu
AU  - Gelaye B
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      MA, USA. bgelaye@hsph.harvard.edu.
FAU - Zhong, Qiu-Yue
AU  - Zhong QY
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      MA, USA. qyzhong@mail.harvard.edu.
FAU - Rondon, Marta B
AU  - Rondon MB
AD  - Department of Medicine, Cayetano Heredia Peruvian University, Lima, Peru. 
      mbrondon@gmail.com.
FAU - Sanchez, Sixto E
AU  - Sanchez SE
AD  - Universidad de Ciencias Aplicadas, Lima, Peru. sixtosanchez@gmail.com.
AD  - Asociacion Civil PROESA, Lima, Peru. sixtosanchez@gmail.com.
FAU - Barrios, Yasmin V
AU  - Barrios YV
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      MA, USA. ybarrios@hsph.harvard.edu.
FAU - Hevner, Karin
AU  - Hevner K
AD  - Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA. 
      Karin.Hevner@swedish.org.
FAU - Qiu, Chunfang
AU  - Qiu C
AD  - Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA. 
      Chun-fang.Qiu@swedish.org.
FAU - Williams, Michelle A
AU  - Williams MA
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, 
      MA, USA. mawilliams@hsph.harvard.edu.
LA  - eng
GR  - R01 HD059835/HD/NICHD NIH HHS/United States
GR  - T32 HD052468/HD/NICHD NIH HHS/United States
GR  - T37 MD001449/MD/NIMHD NIH HHS/United States
GR  - R01-HD-059835/HD/NICHD NIH HHS/United States
GR  - T37-MD000149/MD/NIMHD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150310
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depression, Postpartum/blood/epidemiology/*etiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Peru/epidemiology
MH  - Pregnancy
MH  - Pregnancy Trimester, Second
MH  - Prevalence
MH  - Psychiatric Status Rating Scales
MH  - Young Adult
PMC - PMC4364091
EDAT- 2015/04/18 06:00
MHDA- 2015/10/27 06:00
PMCR- 2015/03/10
CRDT- 2015/04/18 06:00
PHST- 2014/11/30 00:00 [received]
PHST- 2015/02/20 00:00 [accepted]
PHST- 2015/04/18 06:00 [entrez]
PHST- 2015/04/18 06:00 [pubmed]
PHST- 2015/10/27 06:00 [medline]
PHST- 2015/03/10 00:00 [pmc-release]
AID - 10.1186/s12888-015-0428-7 [pii]
AID - 428 [pii]
AID - 10.1186/s12888-015-0428-7 [doi]
PST - epublish
SO  - BMC Psychiatry. 2015 Mar 10;15:43. doi: 10.1186/s12888-015-0428-7.