PMID- 25886760 OWN - NLM STAT- MEDLINE DCOM- 20151110 LR - 20181202 IS - 1472-6882 (Electronic) IS - 1472-6882 (Linking) VI - 15 DP - 2015 Mar 10 TI - Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice. PG - 47 LID - 10.1186/s12906-015-0561-3 [doi] LID - 47 AB - BACKGROUND: Samsoeum has long been used in Korea and other Asian countries as a traditional medicine to treat various diseases. In the present study, we investigated the antiasthma effect of the herbal medicine Samsoeum water extract (SSEW) using an in vivo ovalbumin (OVA)-induced asthmatic model. METHODS: Female BALB/c mice were sensitized by an intraperitoneal injection of OVA and subsequently challenged with nebulized OVA. We investigated the number of inflammatory cells, the production of Th1/Th2 cytokines and chemokine in bronchoalveolar lavage fluid (BALF), histological changes in lung tissue, the infiltration of inflammatory cells and hyperplasia of goblet cells in lung tissue, the levels of immunoglobulin E (IgE) in BALF and plasma, and the expression of inducible nitric oxide synthase (iNOS) in lung tissue. RESULTS: Our findings indicated that SSEW decreased the accumulation of inflammatory cells (particularly, eosinophil and neutrophil) and regulated the balance in the production of Th1/Th2 cytokines and chemokine in BALF. Moreover, SSEW suppressed the level of IgE in BALF and plasma, and inhibited the infiltration of inflammatory cells, hyperplasia of goblet cells, and the expression of iNOS in lung tissue. CONCLUSIONS: Collectively, these results suggest that, because of its anti-inflammatory and antiasthma properties, SSEW may be useful in reducing airway inflammation in the treatment of allergic asthma. FAU - Jeon, Woo-Young AU - Jeon WY AD - Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine, 483 Expo-ro, Yusung-gu, Daejeon, 305-811, Republic of Korea. ssamggun85@kiom.re.kr. FAU - Shin, In-Sik AU - Shin IS AD - Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine, 483 Expo-ro, Yusung-gu, Daejeon, 305-811, Republic of Korea. dvmmk79@gmail.com. AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, O-chang uep, Cheongwon-gun, Cheongju-si, Chungbuk, 363-883, Republic of Korea. dvmmk79@gmail.com. AD - Pharmacology, College of Veterinary Medicine, Chonnam National University, Gwangju, 500-757, Republic of Korea. dvmmk79@gmail.com. FAU - Shin, Hyeun-Kyoo AU - Shin HK AD - Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine, 483 Expo-ro, Yusung-gu, Daejeon, 305-811, Republic of Korea. hkshin@kiom.re.kr. FAU - Lee, Mee-Young AU - Lee MY AD - Herbal Medicine Formulation Research Group, Korea Institute of Oriental Medicine, 483 Expo-ro, Yusung-gu, Daejeon, 305-811, Republic of Korea. cozy11@kiom.re.kr. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150310 PL - England TA - BMC Complement Altern Med JT - BMC complementary and alternative medicine JID - 101088661 RN - 0 (Anti-Asthmatic Agents) RN - 0 (Anti-Inflammatory Agents) RN - 0 (Chemokines) RN - 0 (Cytokines) RN - 0 (Drugs, Chinese Herbal) RN - 0 (shensuyin) RN - 37341-29-0 (Immunoglobulin E) RN - 9006-59-1 (Ovalbumin) RN - EC 1.14.13.39 (NOS2 protein, human) RN - EC 1.14.13.39 (Nitric Oxide Synthase Type II) SB - IM MH - Animals MH - Anti-Asthmatic Agents/*pharmacology/therapeutic use MH - Anti-Inflammatory Agents/*pharmacology/therapeutic use MH - Asthma/drug therapy/immunology/*metabolism/pathology MH - Bronchoalveolar Lavage Fluid MH - Chemokines/metabolism MH - Cytokines/metabolism MH - Drugs, Chinese Herbal/*pharmacology/therapeutic use MH - Eosinophils/metabolism MH - Female MH - Goblet Cells/drug effects MH - Immunoglobulin E/blood MH - Inflammation/drug therapy/*metabolism MH - Lung/*drug effects/metabolism/pathology MH - Magnoliopsida MH - Mice, Inbred BALB C MH - Neutrophils/metabolism MH - Nitric Oxide Synthase Type II/metabolism MH - Ovalbumin/adverse effects MH - Phytotherapy MH - Poria MH - Republic of Korea MH - Th1-Th2 Balance/*drug effects PMC - PMC4363060 EDAT- 2015/04/19 06:00 MHDA- 2015/11/11 06:00 PMCR- 2015/03/10 CRDT- 2015/04/19 06:00 PHST- 2014/08/19 00:00 [received] PHST- 2015/02/18 00:00 [accepted] PHST- 2015/04/19 06:00 [entrez] PHST- 2015/04/19 06:00 [pubmed] PHST- 2015/11/11 06:00 [medline] PHST- 2015/03/10 00:00 [pmc-release] AID - 10.1186/s12906-015-0561-3 [pii] AID - 561 [pii] AID - 10.1186/s12906-015-0561-3 [doi] PST - epublish SO - BMC Complement Altern Med. 2015 Mar 10;15:47. doi: 10.1186/s12906-015-0561-3.