PMID- 25887877
OWN - NLM
STAT- MEDLINE
DCOM- 20160113
LR  - 20150418
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 45
IP  - 2
DP  - 2015 Spring
TI  - Detailed analysis of isodicentric Y in a case with azoospermia and 
      45,x/46,x,idic(Y) mosaicism.
PG  - 206-8
AB  - Isodicentric chromosomes are the most commonly reported aberrations of the human 
      Y chromosome. We characterized the isodicentric Y chromosome from an azoospermic 
      male by fluorescence in situ hybridization (FISH) and PCR. The patient was a 
      33-year-old man who visited our hospital for evaluation of infertility. He 
      expressed male external genitalia and showed normal testosterone levels. However, 
      severe varicocele on both sides and hydrocele of the right side were found upon 
      ultrasonography of the scrotum, and no sperm were found on semen analysis. The 
      patient showed 46,X,idic(Y)(q11.22)[58]/45,X[12] karyotype. FISH demonstrated the 
      presence of two centromeres and two SRY regions (74.0% of cells counted). PCR 
      showed the breakpoint between SY161 and SY121 in Yq11.221-q11.222.
CI  - (c) 2015 by the Association of Clinical Scientists, Inc.
FAU - Lee, Jaehyeon
AU  - Lee J
AD  - Department of Laboratory Medicine, Chonbuk National University Medical School, 
      Jeonju.
FAU - Park, Jong Kwan
AU  - Park JK
AD  - Department of Urology, Chonbuk National University Medical School, Jeonju 
      Research Institute of Clinical Medicine of Chonbuk National University-Biomedical 
      Research Institute of Chonbuk National University Hospital, Korea.
FAU - Kim, Dal Sik
AU  - Kim DS
AD  - Department of Laboratory Medicine, Chonbuk National University Medical School, 
      Jeonju Research Institute of Clinical Medicine of Chonbuk National 
      University-Biomedical Research Institute of Chonbuk National University Hospital, 
      Korea.
FAU - Lee, Hye Soo
AU  - Lee HS
AD  - Department of Laboratory Medicine, Chonbuk National University Medical School, 
      Jeonju Research Institute of Clinical Medicine of Chonbuk National 
      University-Biomedical Research Institute of Chonbuk National University Hospital, 
      Korea.
FAU - Choi, Sam Im
AU  - Choi SI
AD  - Department of Laboratory Medicine, Chonbuk National University Medical School, 
      Jeonju Research Institute of Clinical Medicine of Chonbuk National 
      University-Biomedical Research Institute of Chonbuk National University Hospital, 
      Korea.
FAU - Cho, Yong Gon
AU  - Cho YG
AD  - Department of Laboratory Medicine, Chonbuk National University Medical School, 
      Jeonju Research Institute of Clinical Medicine of Chonbuk National 
      University-Biomedical Research Institute of Chonbuk National University Hospital, 
      Korea choyg@jbnu.ac.kr.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
SB  - IM
MH  - Adult
MH  - Azoospermia/*genetics
MH  - *Chromosome Aberrations
MH  - Chromosome Deletion
MH  - Chromosomes, Human, X/*genetics
MH  - Chromosomes, Human, Y/*genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - *Mosaicism
EDAT- 2015/04/19 06:00
MHDA- 2016/01/14 06:00
CRDT- 2015/04/19 06:00
PHST- 2015/04/19 06:00 [entrez]
PHST- 2015/04/19 06:00 [pubmed]
PHST- 2016/01/14 06:00 [medline]
AID - 45/2/206 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2015 Spring;45(2):206-8.