PMID- 25887997
OWN - NLM
STAT- MEDLINE
DCOM- 20160222
LR  - 20220408
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 15
DP  - 2015 Mar 19
TI  - Identifying patients with chronic hepatitis B at high risk of type 2 diabetes 
      mellitus: a cross-sectional study with pair-matched controls.
PG  - 32
LID - 10.1186/s12876-015-0263-9 [doi]
LID - 32
AB  - BACKGROUND: The presence of diabetes mellitus (DM) is associated with increased 
      liver morbidity and mortality risk in patients with chronic hepatitis B (CHB). 
      Aim of this study was to identify factors associated with type 2 diabetes 
      mellitus (T2DM) in CHB patients. METHODS: A cross-sectional study with 
      pair-matched controls was conducted in Nantong Third People's Hospital, Nantong 
      University, China. From January 2008 to December 2012, a total of 1783 CHB 
      patients were screened for study subjects, among whom 207 patients with T2DM were 
      enrolled as cases and 207 sex- and age-matched non-DM patients as controls. 
      Demographic, anthropometric, lifestyle, clinical, and laboratory data were 
      obtained from each subject. RESULTS: In the univariate model, thirteen variables 
      showed marked differences between the DM group and non-DM group. Patients with 
      longer duration of CHB (>/=15 years) and alcoholic steatosis showed the highest 
      likelihood of T2DM (odds ratio = 5.39 and 4.95; 95% confidence intervals 
      2.76-10.53 and 1.65-14.91). In the multivariate adjusted analysis, three 
      CHB-related factors, namely high viral load, long duration of illness, and 
      presence of cirrhosis, contributed to substantially increase the likelihood of 
      T2DM, in addition to the other five risk factors including family history of DM, 
      low education level, elevated triglycerides (TG), gamma-glutamyl transferase 
      (GGT) levels, and presence of alcoholic steatosis. CONCLUSIONS: Our findings 
      suggest that high viral load, long duration of CHB, presence of cirrhosis, 
      alcoholic steatosis and several other factors may be potential risk factors for 
      development of T2DM in CHB patients. It is of vital importance to monitor glucose 
      in high-risk CHB patients and aggressively intervene on modifiable risk factors.
FAU - Shen, Yi
AU  - Shen Y
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Nantong University, Nantong, Jiangsu, 226019, China. sunny@ntu.edu.cn.
AD  - Center for Liver Diseases, Nantong Third People's Hospital, Nantong University, 
      Nantong, Jiangsu, 226006, China. sunny@ntu.edu.cn.
FAU - Zhang, Jian
AU  - Zhang J
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Nantong University, Nantong, Jiangsu, 226019, China. 269109654@qq.com.
FAU - Cai, Hui
AU  - Cai H
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Nantong University, Nantong, Jiangsu, 226019, China. huicai2012@yahoo.com.
FAU - Shao, Jian-Guo
AU  - Shao JG
AD  - Center for Liver Diseases, Nantong Third People's Hospital, Nantong University, 
      Nantong, Jiangsu, 226006, China. shaojianguo4144@163.com.
FAU - Zhang, You-Yi
AU  - Zhang YY
AD  - Center for Liver Diseases, Nantong Third People's Hospital, Nantong University, 
      Nantong, Jiangsu, 226006, China. youyizhang@ntu.edu.cn.
FAU - Liu, Yan-Mei
AU  - Liu YM
AD  - Department of Epidemiology and Medical Statistics, School of Public Health, 
      Nantong University, Nantong, Jiangsu, 226019, China. 13180014@yjs.ntu.edu.cn.
FAU - Qin, Gang
AU  - Qin G
AD  - Center for Liver Diseases, Nantong Third People's Hospital, Nantong University, 
      Nantong, Jiangsu, 226006, China. tonygqin@ntu.edu.cn.
FAU - Qin, Yan
AU  - Qin Y
AD  - Department of Internal Medicine, Singapore General Hospital, Singapore, 169608, 
      Singapore. qin.yan@sgh.com.sg.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150319
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - China/epidemiology
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/blood/epidemiology/*etiology/genetics
MH  - Educational Status
MH  - Fatty Liver, Alcoholic/epidemiology
MH  - Female
MH  - Hepatitis B, Chronic/blood/*complications/epidemiology
MH  - Humans
MH  - Hypertriglyceridemia/epidemiology
MH  - Liver Cirrhosis/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Time Factors
MH  - Viral Load
MH  - gamma-Glutamyltransferase/blood
PMC - PMC4387579
EDAT- 2015/04/19 06:00
MHDA- 2016/02/24 06:00
PMCR- 2015/03/19
CRDT- 2015/04/19 06:00
PHST- 2014/11/05 00:00 [received]
PHST- 2015/03/04 00:00 [accepted]
PHST- 2015/04/19 06:00 [entrez]
PHST- 2015/04/19 06:00 [pubmed]
PHST- 2016/02/24 06:00 [medline]
PHST- 2015/03/19 00:00 [pmc-release]
AID - 10.1186/s12876-015-0263-9 [pii]
AID - 263 [pii]
AID - 10.1186/s12876-015-0263-9 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2015 Mar 19;15:32. doi: 10.1186/s12876-015-0263-9.