PMID- 25888866
OWN - NLM
STAT- MEDLINE
DCOM- 20160407
LR  - 20220408
IS  - 1748-717X (Electronic)
IS  - 1748-717X (Linking)
VI  - 10
DP  - 2015 Apr 8
TI  - Tangential volumetric modulated arc therapy technique for left-sided breast 
      cancer radiotherapy.
PG  - 79
LID - 10.1186/s13014-015-0392-x [doi]
LID - 79
AB  - BACKGROUND: The aim of the present study was to introduce a new restricted 
      tangential volumetric modulated arc therapy (tVMAT) technique for whole breast 
      irradiation and compare its dosimetric properties to other currently used breast 
      cancer radiotherapy techniques. METHOD: Ten consecutive women with left-sided 
      breast cancer were enrolled in this retrospective study. Four treatment plans 
      were generated for each patient: 1) standard tangential field-in-field (FinF), 2) 
      tangential intensity modulated radiotherapy (tIMRT), 3) tangential VMAT (tVMAT) 
      with two dual arcs of 50-60 degrees  and 4) continuous VMAT (cVMAT) with a dual arc of 
      240 degrees . The plans were created with Monaco(R) (tIMRT, tVMAT and cVMAT) and Oncentra(R) 
      (FinF) treatment planning systems. RESULTS: With both VMAT techniques 
      significantly higher cardiac avoidance, dose coverage and dose homogenity were 
      achieved when compared with FinF or tIMRT techniques (p < 0.01). VMAT techniques 
      also decreased the high dose areas (above 20 Gy) of ipsilateral lung. There were 
      no significant differences in the mean dose of contralateral breast between the 
      tVMAT, tIMRT and FinF techniques. The dose coverage (V47.5 Gy) was greatest with 
      cVMAT. However, with cVMAT the increase of contralateral breast dose was 
      significant. CONCLUSIONS: The present results support the hypothesis that the 
      introduced tVMAT technique is feasible for treatment of left-sided breast cancer. 
      With tVMAT dose to heart and ipsilateral lung can be reduced and the dose 
      homogeneity can be improved without increasing the dose to contralateral breast 
      or lung.
FAU - Viren, Tuomas
AU  - Viren T
AD  - Cancer Center, Kuopio University Hospital, PO Box 100, FI-70029, Kuopio, Finland. 
      Tuomas.Viren@kuh.fi.
FAU - Heikkila, Janne
AU  - Heikkila J
AD  - Cancer Center, Kuopio University Hospital, PO Box 100, FI-70029, Kuopio, Finland. 
      Janne.Heikkila@kuh.fi.
FAU - Myllyoja, Kimmo
AU  - Myllyoja K
AD  - Cancer Center, Kuopio University Hospital, PO Box 100, FI-70029, Kuopio, Finland. 
      Kimmo.Myllyoja@kuh.fi.
FAU - Koskela, Kristiina
AU  - Koskela K
AD  - Cancer Center, Kuopio University Hospital, PO Box 100, FI-70029, Kuopio, Finland. 
      Kristiina.Koskela@kuh.fi.
FAU - Lahtinen, Tapani
AU  - Lahtinen T
AD  - Cancer Center, Kuopio University Hospital, PO Box 100, FI-70029, Kuopio, Finland. 
      Tapani.Lahtinen@kuh.fi.
FAU - Seppala, Jan
AU  - Seppala J
AD  - Cancer Center, Kuopio University Hospital, PO Box 100, FI-70029, Kuopio, Finland. 
      Jan.Seppala@kuh.fi.
LA  - eng
PT  - Journal Article
DEP - 20150408
PL  - England
TA  - Radiat Oncol
JT  - Radiation oncology (London, England)
JID - 101265111
SB  - IM
MH  - Aged
MH  - Female
MH  - Heart/radiation effects
MH  - Humans
MH  - Lung/radiation effects
MH  - Prognosis
MH  - Radiometry/*methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
MH  - Retrospective Studies
MH  - Unilateral Breast Neoplasms/*radiotherapy
PMC - PMC4404692
EDAT- 2015/04/19 06:00
MHDA- 2016/04/08 06:00
PMCR- 2015/04/08
CRDT- 2015/04/19 06:00
PHST- 2014/12/24 00:00 [received]
PHST- 2015/03/25 00:00 [accepted]
PHST- 2015/04/19 06:00 [entrez]
PHST- 2015/04/19 06:00 [pubmed]
PHST- 2016/04/08 06:00 [medline]
PHST- 2015/04/08 00:00 [pmc-release]
AID - 10.1186/s13014-015-0392-x [pii]
AID - 392 [pii]
AID - 10.1186/s13014-015-0392-x [doi]
PST - epublish
SO  - Radiat Oncol. 2015 Apr 8;10:79. doi: 10.1186/s13014-015-0392-x.