PMID- 25889603 OWN - NLM STAT- MEDLINE DCOM- 20160408 LR - 20211203 IS - 1478-6362 (Electronic) IS - 1478-6354 (Print) IS - 1478-6354 (Linking) VI - 17 IP - 1 DP - 2015 Apr 14 TI - Association of HLA-B*41:02 with Henoch-Schonlein Purpura (IgA Vasculitis) in Spanish individuals irrespective of the HLA-DRB1 status. PG - 102 LID - 10.1186/s13075-015-0622-5 [doi] LID - 102 AB - INTRODUCTION: A study was conducted to determine whether the human leukocyte antigen (HLA) B alleles are implicated in the susceptibility to Henoch-Schonlein purpura (HSP) in the largest series of Caucasian HSP patients ever assessed for genetic studies. METHODS: The study population was composed of 349 Spanish patients diagnosed with HSP fulfilling the American College of Rheumatology and the Michel et al. classification criteria, and 335 sex and ethnically matched controls. HLA-B phenotypes were determined by sequencing-based typing (SBT) and analyzed by chi-square or Fisher exact test. RESULTS: A statistically significant increase of HLA-B*41:02 allele in HSP patients when compared with controls was found (8.3% versus 1.5% respectively; P = 0.0001; OR (odds ratio) =5.76 [2.15-19.3]). These results remained statistically significant after adjusting for Bonferroni correction (P = 0.0028). An internal validation also confirmed the susceptibility effect on HSP associated with HLA-B*41:02 (OR = 5.70 [1.98-16.44]). Since a former study described an association between HLA-DRB1*01:03 and HSP susceptibility, we also evaluated the implication of HLA-B*41:02 independently of HLA-DRB1*01:03. Interestingly, the association remained statistically significant (P = 0.0004, OR = 4.97 [1.8-16.9]). No HLA-B association with specific HSP clinical features was found. CONCLUSIONS: Our study indicates that HLA-B*41:02 is associated with the susceptibility to HSP in Spanish patients irrespective of HLA-DRB1 status. FAU - Lopez-Mejias, Raquel AU - Lopez-Mejias R AD - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain. rlopezmejias78@gmail.com. FAU - Genre, Fernanda AU - Genre F AD - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain. fernandagenre@gmail.com. FAU - Perez, Belen Sevilla AU - Perez BS AD - Medicine Department, Hospital Universitario San Cecilio, Granada, Spain. belensev@hotmail.com. FAU - Castaneda, Santos AU - Castaneda S AD - Rheumatology Department, Hospital Universitario La Princesa, IIS-Princesa, Madrid, Spain. scastas@gmail.com. FAU - Ortego-Centeno, Norberto AU - Ortego-Centeno N AD - Medicine Department, Hospital Universitario San Cecilio, Granada, Spain. nortego@gmail.com. FAU - Llorca, Javier AU - Llorca J AD - Epidemiology and Computational Biology Department, School of Medicine, University of Cantabria, and CIBER Epidemiologia y Salud Publica (CIBERESP), IDIVAL, Santander, Spain. llorcaj@unican.es. FAU - Ubilla, Begona AU - Ubilla B AD - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain. b.ubilla.garcia@gmail.com. FAU - Remuzgo-Martinez, Sara AU - Remuzgo-Martinez S AD - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain. sara.r.mtz@gmail.com. FAU - Mijares, Veronica AU - Mijares V AD - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain. necover23@yahoo.es. FAU - Pina, Trinitario AU - Pina T AD - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain. alicantrino@hotmail.com. FAU - Calvo-Rio, Vanesa AU - Calvo-Rio V AD - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain. fiorelfa@hotmail.com. FAU - Marquez, Ana AU - Marquez A AD - Institute of Parasitology and Biomedicine Lopez-Neyra (IPBLN-CSIC) and Systemic Autoimmune Diseases Unit, Hospital Clinico San Cecilio, Granada, Spain. anamaort@ipb.csic.es. FAU - Miranda-Filloy, Jose A AU - Miranda-Filloy JA AD - Division of Rheumatology, Hospital Universitario Lucus Augusti, Lugo, Spain. jose.alberto.miranda.filloy@sergas.es. FAU - Parejo, Antonio Navas AU - Parejo AN AD - Nephrology Department, Hospital Universitario San Cecilio, Granada, Spain. antonionavasparejo@gmail.com. FAU - Conde-Jaldon, Marta AU - Conde-Jaldon M AD - Immunology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain. marta.condejaldon@gmail.com. FAU - Ortiz-Fernandez, Lourdes AU - Ortiz-Fernandez L AD - Immunology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain. lortiz-ibis@us.es. FAU - Argila, Diego AU - Argila D AD - Dermatology Department, IIS-IP, Hospital de la Princesa, Madrid, Spain. dargilad@hotmail.com. FAU - Aragues, Maximiliano AU - Aragues M AD - Dermatology Department, IIS-IP, Hospital de la Princesa, Madrid, Spain. maragues@aedv.es. FAU - Rubio, Esteban AU - Rubio E AD - Rheumatology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain. cybereste@hotmail.com. FAU - Luque, Manuel Leon AU - Luque ML AD - Rheumatology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain. manuelleonluque@gmail.com. FAU - Blanco-Madrigal, Juan Maria AU - Blanco-Madrigal JM AD - Rheumatology Department, Hospital Universitario de Basurto, Bilbao, Spain. juanmaria.blancomadrigal@osakidetza.net. FAU - Galindez-Aguirregoikoa, Eva AU - Galindez-Aguirregoikoa E AD - Rheumatology Department, Hospital Universitario de Basurto, Bilbao, Spain. evagalindez@gmail.com. FAU - Gonzalez Escribano, Francisca AU - Gonzalez Escribano F AD - Immunology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain. pacagonzalez@hotmail.com. FAU - Ocejo-Vinyals, J Gonzalo AU - Ocejo-Vinyals JG AD - Immunology Department, Hospital Universitario Marques de Valdecilla, Santander, Spain. jgocejo@humv.es. FAU - Martin, Javier AU - Martin J AD - Institute of Parasitology and Biomedicine Lopez-Neyra, CSIC, Granada, Spain. martin@ipb.csic.es. FAU - Blanco, Ricardo AU - Blanco R AD - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain. rblanco@humv.es. FAU - Gonzalez-Gay, Miguel A AU - Gonzalez-Gay MA AD - Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, Hospital Universitario Marques de Valdecilla, IDIVAL, Santander, Spain. miguelaggay@hotmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150414 PL - England TA - Arthritis Res Ther JT - Arthritis research & therapy JID - 101154438 RN - 0 (HLA-B Antigens) RN - 0 (HLA-B*41 antigen) RN - 0 (HLA-DRB1 Chains) SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Follow-Up Studies MH - *Genetic Association Studies/methods MH - Genetic Predisposition to Disease/*genetics MH - HLA-B Antigens/*genetics MH - HLA-DRB1 Chains/*genetics MH - Humans MH - IgA Vasculitis/diagnosis/*epidemiology/*genetics MH - Male MH - Spain/epidemiology MH - Young Adult PMC - PMC4416391 EDAT- 2015/04/19 06:00 MHDA- 2016/04/09 06:00 PMCR- 2015/04/14 CRDT- 2015/04/19 06:00 PHST- 2015/01/15 00:00 [received] PHST- 2015/04/08 00:00 [accepted] PHST- 2015/04/19 06:00 [entrez] PHST- 2015/04/19 06:00 [pubmed] PHST- 2016/04/09 06:00 [medline] PHST- 2015/04/14 00:00 [pmc-release] AID - 10.1186/s13075-015-0622-5 [pii] AID - 622 [pii] AID - 10.1186/s13075-015-0622-5 [doi] PST - epublish SO - Arthritis Res Ther. 2015 Apr 14;17(1):102. doi: 10.1186/s13075-015-0622-5.