PMID- 25892179
OWN - NLM
STAT- MEDLINE
DCOM- 20160303
LR  - 20220318
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Linking)
VI  - 12
IP  - 2
DP  - 2015 Aug
TI  - DJ-1-induced phosphatase and tensin homologue downregulation is associated with 
      proliferative and invasive activity of laryngeal cancer cells.
PG  - 2003-8
LID - 10.3892/mmr.2015.3617 [doi]
AB  - DJ-1, a novel mitogen-dependent oncogene, has an important role in the 
      progression of human malignancies, whereas tumor suppressor phosphatase and 
      tensin homolog (PTEN) is known to control a variety of processes associated with 
      cell survival, proliferation and invasion. DJ-1 overexpression was reported to be 
      negatively correlated with PTEN expression in tumor tissues of patients with 
      laryngeal squamous cell carcinoma (LSCC). In the present study, the effect of 
      DJ-1 on PTEN in laryngeal cancer cells was investigated by transfecting 
      DJ-1-specific small interfering (si)RNA into Hep-2 and SNU-899 cells. Cell 
      survival and cell proliferative and invasive capacity were then evaluated. The 
      results showed that siRNA targeting of DJ-1 effectively upregulated PTEN 
      expression, resulting in enhanced cell death as well as decreased proliferation 
      and invasion of Hep-2 and SNU-899 cells. The results of the present study 
      indicated, for the first time, to the best of our knowledge, that DJ-1-induced 
      PTEN downregulation is associated with proliferative and invasive activity of 
      laryngeal cancer cells. The DJ-1 gene may have an important role in the 
      tumorigenesis of LSCC.
FAU - Zhu, Xiao-Lin
AU  - Zhu XL
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.
FAU - Sun, Wei
AU  - Sun W
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.
FAU - Lei, Wen-Bin
AU  - Lei WB
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.
FAU - Zhuang, Hui-Wen
AU  - Zhuang HW
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.
FAU - Hou, Wei-Jian
AU  - Hou WJ
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.
FAU - Wen, Wei-Ping
AU  - Wen WP
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, The First Affiliated 
      Hospital of Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150415
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Oncogene Proteins)
RN  - 0 (RNA, Small Interfering)
RN  - EC 3.1.2.- (PARK7 protein, human)
RN  - EC 3.1.2.- (Protein Deglycase DJ-1)
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
RN  - EC 3.1.3.67 (PTEN protein, human)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement
MH  - Down-Regulation
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Intracellular Signaling Peptides and Proteins/*genetics
MH  - Laryngeal Neoplasms/*genetics/pathology
MH  - Larynx/metabolism/pathology
MH  - Neoplasm Invasiveness/*genetics/pathology
MH  - Oncogene Proteins/*genetics
MH  - PTEN Phosphohydrolase/*genetics
MH  - Protein Deglycase DJ-1
MH  - RNA Interference
MH  - RNA, Small Interfering/genetics
EDAT- 2015/04/22 06:00
MHDA- 2016/03/05 06:00
CRDT- 2015/04/21 06:00
PHST- 2014/06/26 00:00 [received]
PHST- 2015/03/12 00:00 [accepted]
PHST- 2015/04/21 06:00 [entrez]
PHST- 2015/04/22 06:00 [pubmed]
PHST- 2016/03/05 06:00 [medline]
AID - 10.3892/mmr.2015.3617 [doi]
PST - ppublish
SO  - Mol Med Rep. 2015 Aug;12(2):2003-8. doi: 10.3892/mmr.2015.3617. Epub 2015 Apr 15.