PMID- 25892359
OWN - NLM
STAT- MEDLINE
DCOM- 20160331
LR  - 20181202
IS  - 1552-8618 (Electronic)
IS  - 0730-7268 (Linking)
VI  - 34
IP  - 9
DP  - 2015 Sep
TI  - Using cytochrome P4501A1 expression in liver and blubber to understand effects of 
      persistent organic pollutant exposure in stranded Pacific Island cetaceans.
PG  - 1989-95
LID - 10.1002/etc.3018 [doi]
AB  - Elevated levels of persistent organic pollutants (POPs) have been reported in 
      tropical Pacific Island cetaceans and their environment. In addition, recent 
      health concerns in cetacean populations have warranted investigation into 
      potential physiological effects from POP exposure for this region. Cytochrome 
      P450 1A1 (CYP1A1) is a candidate for examining such effects. This well-studied 
      biomarker of exposure and effect was examined in stranded cetacean liver using 
      immunoblot (n = 39, 16 species) and blubber using immunohistochemistry (n = 23, 
      10 species). Paired tissue samples allowed for CYP1A1 comparisons not only 
      between species but also within each individual animal to examine differences 
      between tissue types. Liver CYP1A1 expression correlated positively and 
      significantly with blubber concentrations of all POP categories (n = 39, p < 
      0.050) except octachlorostyrene and pentachlorobenzene (p > 0.100). Among 
      Stenella species, liver CYP1A1 tissue expression was correlated negatively with 
      the sum of all blubber layer endothelial cell CYP1A1 expression (n = 14, p = 
      0.049). Overall, elevated expression of liver CYP1A1 confirms its use as a 
      biomarker of POP exposure to cetaceans stranded in the tropical Pacific basin.
CI  - (c) 2015 SETAC.
FAU - Bachman, Melannie J
AU  - Bachman MJ
AD  - Department of Natural Sciences, Hawaii Pacific University, Kaneohe, Hawaii, USA.
AD  - Hollings Marine Laboratory, Chemical Sciences Division, National Institute of 
      Standards and Technology, Charleston, South Carolina, USA.
FAU - Foltz, Kerry M
AU  - Foltz KM
AD  - Department of Natural Sciences, Hawaii Pacific University, Kaneohe, Hawaii, USA.
FAU - Lynch, Jennifer M
AU  - Lynch JM
AD  - Hollings Marine Laboratory, Chemical Sciences Division, National Institute of 
      Standards and Technology, Charleston, South Carolina, USA.
FAU - West, Kristi L
AU  - West KL
AD  - Department of Natural Sciences, Hawaii Pacific University, Kaneohe, Hawaii, USA.
FAU - Jensen, Brenda A
AU  - Jensen BA
AD  - Department of Natural Sciences, Hawaii Pacific University, Kaneohe, Hawaii, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20150622
PL  - United States
TA  - Environ Toxicol Chem
JT  - Environmental toxicology and chemistry
JID - 8308958
RN  - 0 (Organic Chemicals)
RN  - 0 (Water Pollutants, Chemical)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Adipose Tissue/drug effects/*metabolism
MH  - Animals
MH  - Cetacea/*metabolism
MH  - Cytochrome P-450 CYP1A1/*metabolism
MH  - Immunoblotting
MH  - Immunohistochemistry
MH  - Liver/drug effects/*metabolism
MH  - Organic Chemicals/chemistry/*toxicity
MH  - Pacific Islands
MH  - Up-Regulation/*drug effects
MH  - Water Pollutants, Chemical/chemistry/*toxicity
OTO - NOTNLM
OT  - Biomarker
OT  - Cetaceans
OT  - Cytochrome P450
OT  - Hawaii
OT  - Persistent organic pollutants
EDAT- 2015/04/22 06:00
MHDA- 2016/04/01 06:00
CRDT- 2015/04/21 06:00
PHST- 2014/10/31 00:00 [received]
PHST- 2014/12/19 00:00 [revised]
PHST- 2015/04/05 00:00 [accepted]
PHST- 2015/04/21 06:00 [entrez]
PHST- 2015/04/22 06:00 [pubmed]
PHST- 2016/04/01 06:00 [medline]
AID - 10.1002/etc.3018 [doi]
PST - ppublish
SO  - Environ Toxicol Chem. 2015 Sep;34(9):1989-95. doi: 10.1002/etc.3018. Epub 2015 
      Jun 22.