PMID- 25893035
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150420
LR  - 20200929
IS  - 1943-8141 (Print)
IS  - 1943-8141 (Electronic)
IS  - 1943-8141 (Linking)
VI  - 7
IP  - 2
DP  - 2015
TI  - MSM ameliorates HIV-1 Tat induced neuronal oxidative stress via rebalance of the 
      glutathione cycle.
PG  - 328-38
AB  - HIV-1 Tat protein is a key neuropathological element in HIV associated 
      neurogcognitive disorders (HAND); a type of cognitive syndrome thought to be at 
      least partially mediated by increased levels of brain reactive oxygen species 
      (ROS) and nitric oxide (NO). Methylsulfonylmethane (MSM) is a sulfur-containing 
      compound known to reduce oxidative stress. This study was conducted to determine 
      whether administration of MSM attenuates HIV-1 Tat induced oxidative stress in 
      mouse neuronal cells. MSM treatment significantly decreased neuronal cell NO and 
      ROS secretion. Further, MSM significantly reversed HIV-1 Tat mediated reductions 
      in reduced glutathione (GSH) as well as HIV-1 Tat mediated increases in oxidized 
      glutathione (GSSG). In addition, Tat reduced nuclear translocation of nuclear 
      factor-erythroid 2 p45-related factor 2 (Nrf2), a key nuclear promoter of 
      antioxidant activity, while MSM increased its translocation to the nucleus in the 
      presence of Tat. These results suggest that HIV-1 Tat reduces the resiliency of 
      neuron cells to oxidative stress which can be reversed by MSM. Given the clinical 
      safety of MSM, future preclinical in vivo studies will be required to further 
      confirm these results in effort to validate MSM as a neuroprotectant in patients 
      at risk of, or who are already diagnosed with, HAND.
FAU - Kim, Seol-Hee
AU  - Kim SH
AD  - Department of Psychiatry, Neuroimmunology Laboratory, University of South 
      Florida, Morsani College of Medicine Tampa, FL, USA ; Department of Neurosurgery 
      and Brain Repair, Center of Excellence for Aging and Brain Repair, University of 
      South Florida, Morsani College of Medicine Tampa, FL, USA.
FAU - Smith, Adam J
AU  - Smith AJ
AD  - Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and 
      Brain Repair, University of South Florida, Morsani College of Medicine Tampa, FL, 
      USA.
FAU - Tan, Jun
AU  - Tan J
AD  - Department of Psychiatry, Rashid Laboratory for Developmental Neurobiology, 
      Silver Child Development Center, University of South Florida, Morsani College of 
      Medicine Tampa, FL, USA.
FAU - Shytle, R Douglas
AU  - Shytle RD
AD  - Department of Neurosurgery and Brain Repair, Center of Excellence for Aging and 
      Brain Repair, University of South Florida, Morsani College of Medicine Tampa, FL, 
      USA.
FAU - Giunta, Brian
AU  - Giunta B
AD  - Department of Psychiatry, Neuroimmunology Laboratory, University of South 
      Florida, Morsani College of Medicine Tampa, FL, USA.
LA  - eng
GR  - R01 MH098737/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20150215
PL  - United States
TA  - Am J Transl Res
JT  - American journal of translational research
JID - 101493030
PMC - PMC4399096
OTO - NOTNLM
OT  - HIV
OT  - cognitive
OT  - glutathione
OT  - methylsulfonylmethane
OT  - oxidative
EDAT- 2015/04/22 06:00
MHDA- 2015/04/22 06:01
PMCR- 2015/02/15
CRDT- 2015/04/21 06:00
PHST- 2014/09/24 00:00 [received]
PHST- 2015/02/03 00:00 [accepted]
PHST- 2015/04/21 06:00 [entrez]
PHST- 2015/04/22 06:00 [pubmed]
PHST- 2015/04/22 06:01 [medline]
PHST- 2015/02/15 00:00 [pmc-release]
PST - epublish
SO  - Am J Transl Res. 2015 Feb 15;7(2):328-38. eCollection 2015.