PMID- 25894678
OWN - NLM
STAT- MEDLINE
DCOM- 20160401
LR  - 20181113
IS  - 1573-6903 (Electronic)
IS  - 0364-3190 (Linking)
VI  - 40
IP  - 5
DP  - 2015 May
TI  - Alterations of Group I mGluRs and BDNF Associated with Behavioral Abnormity in 
      Prenatally Stressed Offspring Rats.
PG  - 1074-82
LID - 10.1007/s11064-015-1565-6 [doi]
AB  - Substantial evidence reveals that prenatal stress is closely linked with abnormal 
      behavior in offspring, but the mechanism remains unclear. In this study, our aim 
      was to observe the alterations of behaviors, metabotropic glutamate receptor-1/5 
      (mGluR1/5) and brain-derived neurotrophic factor (BDNF) in various brain regions 
      of prenatally stressed offspring rats. The forced swimming test (FST) and the 
      open field test (OFT) were carried on 1-month-old offspring rats. The expression 
      levels of mGluR1, mGluR5, and BDNF mRNA were measured in various brain regions of 
      the offspring rats. Our results showed that the immobile time in the FST was 
      significantly increased in the late prenatal stress (LPS) group compared with 
      that in the control group, especially in the female rats. Similarly, in the OFT, 
      the rats in both the mid prenatal stress (MPS) and LPS groups demonstrated 
      anxiety-like behavior, especially the male rats in the LPS group. The expression 
      of mGluR1 protein was increased in the hippocampus and prefrontal cortex of rats 
      from the LPS group, as well as in the prefrontal cortex of rats from the MPS 
      group. Meanwhile, the expression of mGluR5 protein was facilitated in the 
      hippocampus and prefrontal cortex of rats in the LPS group. The expression of 
      mGluR5 protein was increased in the striatum of the female rats in both MPS and 
      LPS groups, and only in the male rats from the LPS group. In addition, the 
      reduced BDNF mRNA level was detected in the hippocampus and prefrontal cortex in 
      the LPS rats, and in the striatum of the female rats in LPS group. These results 
      indicate that alterations of the mGluR1, mGluR5 and BDNF mRNA may contribute to 
      the depression-like and anxiety-like behaviors of prenatally stressed offspring 
      rats.
FAU - Jia, Ning
AU  - Jia N
AD  - Department of Human Anatomy, Histology and Embryology, Xi'an Jiaotong University 
      Health Science Center, Xi'an, 710061, Shaanxi, China.
FAU - Li, Qinghong
AU  - Li Q
FAU - Sun, Hongli
AU  - Sun H
FAU - Song, Qian
AU  - Song Q
FAU - Tang, Guokui
AU  - Tang G
FAU - Sun, Qinru
AU  - Sun Q
FAU - Wang, Weixi
AU  - Wang W
FAU - Chen, Rui
AU  - Chen R
FAU - Li, Hui
AU  - Li H
FAU - Zhu, Zhongliang
AU  - Zhu Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150418
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Grm5 protein, rat)
RN  - 0 (Receptor, Metabotropic Glutamate 5)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (metabotropic glutamate receptor type 1)
SB  - IM
MH  - Animals
MH  - Anxiety/metabolism/psychology
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Depression/metabolism/psychology
MH  - Female
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*metabolism/psychology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, Metabotropic Glutamate 5/*biosynthesis
MH  - Receptors, Metabotropic Glutamate/*biosynthesis
MH  - Stress, Psychological/*metabolism/psychology
EDAT- 2015/04/22 06:00
MHDA- 2016/04/02 06:00
CRDT- 2015/04/21 06:00
PHST- 2014/11/12 00:00 [received]
PHST- 2015/03/30 00:00 [accepted]
PHST- 2015/03/20 00:00 [revised]
PHST- 2015/04/21 06:00 [entrez]
PHST- 2015/04/22 06:00 [pubmed]
PHST- 2016/04/02 06:00 [medline]
AID - 10.1007/s11064-015-1565-6 [doi]
PST - ppublish
SO  - Neurochem Res. 2015 May;40(5):1074-82. doi: 10.1007/s11064-015-1565-6. Epub 2015 
      Apr 18.