PMID- 25894798
OWN - NLM
STAT- MEDLINE
DCOM- 20160111
LR  - 20181113
IS  - 1534-3170 (Electronic)
IS  - 1523-3782 (Linking)
VI  - 17
IP  - 5
DP  - 2015 May
TI  - Transradial intervention in ST elevation myocardial infarction.
PG  - 30
LID - 10.1007/s11886-015-0585-9 [doi]
AB  - Primary percutaneous coronary intervention (PPCI) in ST elevation myocardial 
      infarction (STEMI) represents the current gold standard reperfusion therapy. 
      Recent advances in antiplatelet and anticoagulant therapy have reduced the risk 
      of ischemic complications and mortality in PPCI although this has been at the 
      expense of major bleeding complications. Access site-related bleeding 
      complications account for up to 50 % of major peri-procedural bleeding 
      complications in PCI. Increasing adoption of the radial artery as the default 
      access site has been shown to markedly reduce such major bleeding complications 
      and mortality in selected patient cohorts. Recent data has suggested that 
      adoption of the transradial access site in STEMI PCI procedures is associated 
      with significant reductions in major bleeding complications and mortality in both 
      national registry data and randomised controlled trials. We provide an overview 
      of this data and discuss the remaining uncertainties around the synergy between 
      access site and contemporary antithrombotic and antiplatelet therapy in such 
      patients. Finally, whilst adoption of the radial artery as the default access 
      site in PPCI has yielded a similar reduction in mortality as observed in the 
      switch from thrombolysis to PPCI in the past, its adoption as a default access 
      site is not universal. We discuss the remaining obstacles and challenges for more 
      widespread adoption of the radial access site as the default access site in PPCI.
FAU - Mustafa, Ahmad H S
AU  - Mustafa AH
AD  - Manchester Heart Centre, Manchester Royal Infirmary, Central Manchester 
      University Hospitals NHS Trust, Manchester, UK.
FAU - Holroyd, Eric
AU  - Holroyd E
FAU - Butler, Rob
AU  - Butler R
FAU - Fraser, Doug
AU  - Fraser D
FAU - El-Omar, Magdi
AU  - El-Omar M
FAU - Nolan, James
AU  - Nolan J
FAU - Mamas, Mamas A
AU  - Mamas MA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Cardiol Rep
JT  - Current cardiology reports
JID - 100888969
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Anticoagulants/therapeutic use
MH  - Humans
MH  - Myocardial Infarction/*therapy
MH  - *Percutaneous Coronary Intervention
MH  - Radial Artery/*surgery
MH  - Randomized Controlled Trials as Topic
EDAT- 2015/04/22 06:00
MHDA- 2016/01/12 06:00
CRDT- 2015/04/21 06:00
PHST- 2015/04/21 06:00 [entrez]
PHST- 2015/04/22 06:00 [pubmed]
PHST- 2016/01/12 06:00 [medline]
AID - 10.1007/s11886-015-0585-9 [doi]
PST - ppublish
SO  - Curr Cardiol Rep. 2015 May;17(5):30. doi: 10.1007/s11886-015-0585-9.