PMID- 25896951
OWN - NLM
STAT- MEDLINE
DCOM- 20160426
LR  - 20220318
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Print)
IS  - 0197-4580 (Linking)
VI  - 36
IP  - 7
DP  - 2015 Jul
TI  - Caloric restriction increases ketone bodies metabolism and preserves blood flow 
      in aging brain.
PG  - 2296-2303
LID - S0197-4580(15)00182-7 [pii]
LID - 10.1016/j.neurobiolaging.2015.03.012 [doi]
AB  - Caloric restriction (CR) has been shown to increase the life span and health span 
      of a broad range of species. However, CR effects on in vivo brain functions are 
      far from explored. In this study, we used multimetric neuroimaging methods to 
      characterize the CR-induced changes of brain metabolic and vascular functions in 
      aging rats. We found that old rats (24 months of age) with CR diet had reduced 
      glucose uptake and lactate concentration, but increased ketone bodies level, 
      compared with the age-matched and young (5 months of age) controls. The shifted 
      metabolism was associated with preserved vascular function: old CR rats also had 
      maintained cerebral blood flow relative to the age-matched controls. When 
      investigating the metabolites in mitochondrial tricarboxylic acid cycle, we found 
      that citrate and alpha-ketoglutarate were preserved in the old CR rats. We suggest 
      that CR is neuroprotective; ketone bodies, cerebral blood flow, and 
      alpha-ketoglutarate may play important roles in preserving brain physiology in aging.
CI  - Copyright (c) 2015 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Lin, Ai-Ling
AU  - Lin AL
AD  - Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA; 
      Department of Pharmacology and Nutritional Sciences, University of Kentucky, 
      Lexington, KY, USA. Electronic address: ailing.lin@uky.edu.
FAU - Zhang, Wei
AU  - Zhang W
AD  - Research Imaging Institute, University of Texas Health Science Center at San 
      Antonio, San Antonio, TX, USA.
FAU - Gao, Xiaoli
AU  - Gao X
AD  - Institutional Mass Spectrometry Laboratory, University of Texas Health Science 
      Center at San Antonio, San Antonio, TX, USA; Department of Biochemistry, 
      University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
FAU - Watts, Lora
AU  - Watts L
AD  - Research Imaging Institute, University of Texas Health Science Center at San 
      Antonio, San Antonio, TX, USA; Department of Cellular and Structural Biology, 
      University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
LA  - eng
GR  - K01 AG040164/AG/NIA NIH HHS/United States
GR  - KL2 TR001118/TR/NCATS NIH HHS/United States
GR  - UL1 TR001120/TR/NCATS NIH HHS/United States
GR  - K01AG040164/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150325
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Ketone Bodies)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Brain/*blood supply/*metabolism
MH  - *Caloric Restriction
MH  - *Cerebrovascular Circulation
MH  - Ketone Bodies/*metabolism
MH  - Male
MH  - Rats, Inbred F344
PMC - PMC4457572
MID - NIHMS682669
OTO - NOTNLM
OT  - Aging
OT  - Brain metabolism
OT  - Cerebral blood flow
OT  - Ketone bodies
OT  - Mammalian target of rapamycin
OT  - Neuroimaging
OT  - alpha-ketoglutarate
EDAT- 2015/04/22 06:00
MHDA- 2016/04/27 06:00
PMCR- 2016/07/01
CRDT- 2015/04/22 06:00
PHST- 2014/09/10 00:00 [received]
PHST- 2015/02/10 00:00 [revised]
PHST- 2015/03/19 00:00 [accepted]
PHST- 2015/04/22 06:00 [entrez]
PHST- 2015/04/22 06:00 [pubmed]
PHST- 2016/04/27 06:00 [medline]
PHST- 2016/07/01 00:00 [pmc-release]
AID - S0197-4580(15)00182-7 [pii]
AID - 10.1016/j.neurobiolaging.2015.03.012 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2015 Jul;36(7):2296-2303. doi: 
      10.1016/j.neurobiolaging.2015.03.012. Epub 2015 Mar 25.