PMID- 25897038
OWN - NLM
STAT- MEDLINE
DCOM- 20160128
LR  - 20150919
IS  - 1468-2044 (Electronic)
IS  - 0003-9888 (Linking)
VI  - 100
IP  - 10
DP  - 2015 Oct
TI  - Focused image-guided parathyroidectomy in the current management of primary 
      hyperparathyroidism.
PG  - 924-7
LID - 10.1136/archdischild-2014-308047 [doi]
AB  - OBJECTIVE: Primary hyperparathyroidism (PHPT) in childhood and adolescence has 
      been considered a different disease to that seen in adults, with predominantly 
      familial aetiology mandating open exploration to exclude parathyroid hyperplasia 
      in contrast to the adoption of focused image-guided parathyroidectomy (FP) in 
      adults. STUDY DESIGN: A retrospective cohort study in a tertiary referral 
      hospital setting of all children and adolescents (<18 years) undergoing 
      parathyroid surgery for PHPT. Data were obtained from a dedicated endocrine 
      surgery database and hospital medical records. RESULTS: Over the 35-year study 
      period (1980-2014), there were 31 patients who underwent parathyroidectomy for 
      PHPT. 3 patients were from known multiple endocrine neoplasia type 1 syndrome 
      (MEN1) families, 3 had an isolated family history of PHPT and 25 were sporadic. 
      In the sporadic group, 24 (96%) presented with symptomatic hypercalcaemia, 
      affecting the gastrointestinal, musculoskeletal, genitourinary or 
      neuropsychiatric systems. In the 25 patients with sporadic PHPT, nine (36%) had 
      FP with a single adenoma removed with a 100% initial cure rate. Sixteen patients 
      (64%) in the sporadic group had an open exploration: 14 had single gland disease 
      while 2 patients required a second procedure to achieve a final cure rate of 
      100%. Of the three patients with MEN1, one was cured, one has persistent 
      hyperparathyroidism after FP and the third has permanent hypoparathyroidism after 
      open exploration. CONCLUSIONS: The majority of children and adolescents with PHPT 
      have symptomatic disease due to a single adenoma. They can therefore be managed 
      in a similar fashion to their adult counterparts with preoperative localisation 
      studies aiming to permit FP in a day case setting.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not 
      already granted under a licence) please go to 
      http://group.bmj.com/group/rights-licensing/permissions.
FAU - Langusch, Catherine C
AU  - Langusch CC
AD  - Douglas Cohen Department of Paediatric Surgery, The Children's Hospital at 
      Westmead, Sydney Medical School, The University of Sydney, Sydney, New South 
      Wales, Australia.
FAU - Norlen, Olov
AU  - Norlen O
AD  - University of Sydney Endocrine Surgical Unit, Sydney Medical School, The 
      University of Sydney, Sydney, New South Wales, Australia.
FAU - Titmuss, Angela
AU  - Titmuss A
AD  - Department of Endocrinology, The Children's Hospital at Westmead, Sydney Medical 
      School, The University of Sydney, Sydney, New South Wales, Australia.
FAU - Donoghue, Kim
AU  - Donoghue K
AD  - Department of Endocrinology, The Children's Hospital at Westmead, Sydney Medical 
      School, The University of Sydney, Sydney, New South Wales, Australia.
FAU - Holland, Andrew J A
AU  - Holland AJ
AD  - Douglas Cohen Department of Paediatric Surgery, The Children's Hospital at 
      Westmead, Sydney Medical School, The University of Sydney, Sydney, New South 
      Wales, Australia.
FAU - Shun, Albert
AU  - Shun A
AD  - Douglas Cohen Department of Paediatric Surgery, The Children's Hospital at 
      Westmead, Sydney Medical School, The University of Sydney, Sydney, New South 
      Wales, Australia.
FAU - Delbridge, Leigh
AU  - Delbridge L
AD  - University of Sydney Endocrine Surgical Unit, Sydney Medical School, The 
      University of Sydney, Sydney, New South Wales, Australia.
LA  - eng
PT  - Journal Article
DEP - 20150420
PL  - England
TA  - Arch Dis Child
JT  - Archives of disease in childhood
JID - 0372434
SB  - IM
CIN - Arch Dis Child. 2015 Oct;100(10):904-5. PMID: 26141539
MH  - Adolescent
MH  - Child
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Hyperparathyroidism, Primary/*surgery
MH  - Male
MH  - Parathyroidectomy/adverse effects/*methods
MH  - Retrospective Studies
MH  - *Surgery, Computer-Assisted
OTO - NOTNLM
OT  - Endocrinology
OT  - Paediatric Surgery
OT  - Procedures
EDAT- 2015/04/22 06:00
MHDA- 2016/01/29 06:00
CRDT- 2015/04/22 06:00
PHST- 2014/12/11 00:00 [received]
PHST- 2015/03/25 00:00 [accepted]
PHST- 2015/04/22 06:00 [entrez]
PHST- 2015/04/22 06:00 [pubmed]
PHST- 2016/01/29 06:00 [medline]
AID - archdischild-2014-308047 [pii]
AID - 10.1136/archdischild-2014-308047 [doi]
PST - ppublish
SO  - Arch Dis Child. 2015 Oct;100(10):924-7. doi: 10.1136/archdischild-2014-308047. 
      Epub 2015 Apr 20.