PMID- 25897552
OWN - NLM
STAT- MEDLINE
DCOM- 20160414
LR  - 20220318
IS  - 1557-900X (Electronic)
IS  - 0892-7790 (Linking)
VI  - 29
IP  - 9
DP  - 2015 Sep
TI  - A Randomized Controlled Trial for Pain Control in Laparoscopic Urologic Surgery: 
      0.25% Bupivacaine Versus Long-Acting Liposomal Bupivacaine.
PG  - 1019-24
LID - 10.1089/end.2014.0769 [doi]
AB  - BACKGROUND AND PURPOSE: Liposomal bupivacaine is a delayed-release preparation 
      providing up to 72 hours of local analgesia. It costs much more than standard 
      bupivacaine, however. A prospective, randomized, patient-blinded, controlled 
      trial was performed to assess the efficacy of liposomal bupivacaine versus 0.25% 
      bupivacaine when injected into surgical incisions during laparoscopic and 
      robot-assisted urologic surgery. METHODS: A total of 206 adults were randomized 
      to receive liposomal bupivacaine or 0.25% bupivacaine. All surgical incisions 
      were injected with liposomal bupivacaine or 0.25% bupivacaine with systematic 
      dosing. The primary outcome was total opioid consumption during the postoperative 
      hospital stay. All opioid doses were converted to morphine equivalents. Secondary 
      end points included pain scores using visual analog pain scales, duration of 
      hospital stay, and the time to first opioid use. A subgroup analysis was 
      performed for renal surgery patients. RESULTS: There was no significant 
      difference in median total opioid use during the hospital stay between those who 
      received liposomal bupivacaine (15 [interquartile range (IQR) 6.7-27] mg) and 
      0.25% bupivacaine (17.3 [IQR 8.3-30.5] mg) (P=0.39). Furthermore, pain scores, 
      length of hospital stay, and time to first opioid use did not differ between 
      groups. Subgroup analysis of laparoscopic renal surgery revealed no difference 
      between liposomal bupivacaine and 0.25% bupivacaine. CONCLUSIONS: For 
      laparoscopic and robot-assisted urologic surgery, there is no significant 
      difference between liposomal bupivacaine and 0.25% bupivacaine for local 
      analgesia at the incision sites.
FAU - Knight, Richard B
AU  - Knight RB
AD  - 1 Department of Urology, 48th MDG, RAF Lakenheath , Brandon, Suffolk, United 
      Kingdom .
FAU - Walker, Paul W
AU  - Walker PW
AD  - 2 Louisiana Urology , LLC, Baton Rouge, Louisiana.
FAU - Keegan, Kirk A
AU  - Keegan KA
AD  - 3 Department of Urology, San Antonio Military Medical Center , Fort Sam Houston, 
      Texas.
FAU - Overholser, Stephen M
AU  - Overholser SM
AD  - 4 University of Texas Health Science Center at San Antonio , San Antonio, Texas.
FAU - Baumgartner, Timothy S
AU  - Baumgartner TS
AD  - 3 Department of Urology, San Antonio Military Medical Center , Fort Sam Houston, 
      Texas.
FAU - Ebertowski, James S 2nd
AU  - Ebertowski JS 2nd
AD  - 3 Department of Urology, San Antonio Military Medical Center , Fort Sam Houston, 
      Texas.
FAU - Aden, James K
AU  - Aden JK
AD  - 3 Department of Urology, San Antonio Military Medical Center , Fort Sam Houston, 
      Texas.
FAU - White, Michael A
AU  - White MA
AD  - 5 Urology San Antonio , San Antonio, Texas.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150605
PL  - United States
TA  - J Endourol
JT  - Journal of endourology
JID - 8807503
RN  - 0 (Analgesics, Opioid)
RN  - 0 (Anesthetics, Local)
RN  - 0 (Liposomes)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Aged
MH  - Analgesics, Opioid/*administration & dosage
MH  - Anesthetics, Local/*administration & dosage
MH  - Bupivacaine/*administration & dosage
MH  - Female
MH  - Humans
MH  - Laparoscopy/*methods
MH  - Length of Stay
MH  - Liposomes/*chemistry
MH  - Male
MH  - Middle Aged
MH  - Pain Management
MH  - Pain Measurement
MH  - Pain, Postoperative/drug therapy
MH  - Prospective Studies
MH  - Robotic Surgical Procedures
MH  - Surgery, Computer-Assisted
MH  - Urologic Surgical Procedures/*methods
EDAT- 2015/04/22 06:00
MHDA- 2016/04/15 06:00
CRDT- 2015/04/22 06:00
PHST- 2015/04/22 06:00 [entrez]
PHST- 2015/04/22 06:00 [pubmed]
PHST- 2016/04/15 06:00 [medline]
AID - 10.1089/end.2014.0769 [doi]
PST - ppublish
SO  - J Endourol. 2015 Sep;29(9):1019-24. doi: 10.1089/end.2014.0769. Epub 2015 Jun 5.