PMID- 25897822
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20220409
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 41
IP  - 3
DP  - 2016
TI  - Correlation Between Visual Function and Photoreceptor Integrity in Diabetic 
      Macular Edema: Spectral-Domain Optical Coherence Tomography.
PG  - 391-9
LID - 10.3109/02713683.2015.1019003 [doi]
AB  - PURPOSE: To evaluate the relationship between visual function and (i) 
      microstructural changes in the fovea of the inner segment-outer segment junction 
      (IS/OS) and (ii) external limiting membrane (ELM) in diabetic macular edema 
      (DME). METHODS: We conducted a retrospective, observational, cross-sectional 
      study of 40 DME patients (61 eyes), all of whom had been treated at Shanghai 
      First People's Hospital. Patients were divided into groups based on integrity of 
      the IS/OS or ELM: IS/OS (+, +/- and -) and ELM (+, +/- and -). We performed 
      best-corrected visual acuity (BCVA), MP1 microperimetry and spectral-domain 
      optical coherence tomography (SD-OCT) on all patients. Several variables, 
      including IS/OS and ELM integrity, central macular thickness (CMT) and central 
      macular volume (CMV), were evaluated by two observers, each masked to patients' 
      BCVA. Main outcome measures included determination of the association of visual 
      function with SD-OCT results. RESULTS: Significant differences were found between 
      IS/OS (+), IS/OS (+/-) and IS/OS (-) groups in BCVA (66.88 +/- 7.89, 51.60 +/- 9.39, 
      32.64 +/- 17.93 letters, p < 0.001); macular sensitivity (MS; 8.21 +/- 2.91, 
      3.55 +/- 2.75, 2.72 +/- 1.86 dB, p < 0.001); fixation stability within 2 degrees  
      (82.09 +/- 12.76, 66.43 +/- 29.54, 33.73 +/- 29.51%, p < 0.001); and % central fixation 
      (74.87 +/- 16.88, 61.39 +/- 31.38, 31.64 +/- 31.89%, p < 0.001); but no differences 
      were found for CMT (p = 0.069) or CMV (p = 0.069). Results were similar for ELM 
      groups. There were significant differences between ELM (+), ELM (+/-) and ELM (-) 
      groups in BCVA (64.16 +/- 9.49, 50.44 +/- 9.83, 32.73 +/- 17.98 letters, p < 0.001); MS 
      (7.54 +/- 3.22, 3.38 +/- 2.38, 2.20 +/- 1.72 dB, p < 0.001); fixation stability within 
      2 degrees  (81.48 +/- 15.26, 61.12 +/- 31.63, 35.00 +/- 29.07%, p < 0.001); and % central 
      fixation (75.90 +/- 17.33, 55.88 +/- 30.94, 30.09 +/- 33.00%, p < 0.001); but not for 
      CMT (p = 0.216) or CMV (p = 0.202). There was a strong correlation (r = 0.881, 
      p < 0.001) between ELM and IS/OS integrity for the same patient. Categories of 
      IS/OS showed more severe changes than did those of ELM. CONCLUSIONS: Both IS/OS 
      and ELM integrity correlated positively with visual function in DME patients. 
      Further studies are needed to confirm and validate this relationship.
FAU - Shen, Yinchen
AU  - Shen Y
AD  - a Department of Ophthalmology , Shanghai First People's Hospital affiliated with 
      Shanghai Jiao Tong University , Shanghai , People's Republic of China and.
AD  - b Shanghai Jiao Tong University School of Medicine , Shanghai , People's Republic 
      of China.
FAU - Liu, Kun
AU  - Liu K
AD  - a Department of Ophthalmology , Shanghai First People's Hospital affiliated with 
      Shanghai Jiao Tong University , Shanghai , People's Republic of China and.
FAU - Xu, Xun
AU  - Xu X
AD  - a Department of Ophthalmology , Shanghai First People's Hospital affiliated with 
      Shanghai Jiao Tong University , Shanghai , People's Republic of China and.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150421
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Diabetic Retinopathy/diagnosis/*physiopathology
MH  - Female
MH  - Fixation, Ocular/physiology
MH  - Humans
MH  - Macular Edema/diagnosis/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Photoreceptor Cells, Vertebrate/*pathology
MH  - Retina/*physiology
MH  - Retinal Photoreceptor Cell Inner Segment/physiology
MH  - Retinal Photoreceptor Cell Outer Segment/physiology
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/*physiology
MH  - Visual Field Tests
OTO - NOTNLM
OT  - Diabetic macular edema
OT  - external limiting membrane
OT  - inner segment-outer segment junction
OT  - integrity of photoreceptor layer
OT  - microperimetry
OT  - optical coherence tomography
EDAT- 2015/04/22 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/04/22 06:00
PHST- 2015/04/22 06:00 [entrez]
PHST- 2015/04/22 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.3109/02713683.2015.1019003 [doi]
PST - ppublish
SO  - Curr Eye Res. 2016;41(3):391-9. doi: 10.3109/02713683.2015.1019003. Epub 2015 Apr 
      21.