PMID- 25899412
OWN - NLM
STAT- MEDLINE
DCOM- 20151228
LR  - 20220321
IS  - 1432-1084 (Electronic)
IS  - 0938-7994 (Linking)
VI  - 25
IP  - 7
DP  - 2015 Jul
TI  - CT differentiation of poorly-differentiated gastric neuroendocrine tumours from 
      well-differentiated neuroendocrine tumours and gastric adenocarcinomas.
PG  - 1946-57
LID - 10.1007/s00330-015-3600-z [doi]
AB  - PURPOSE: To evaluate the differential CT features of gastric 
      poorly-differentiated neuroendocrine tumours (PD-NETs) from well-differentiated 
      NETs (WD-NETs) and gastric adenocarcinomas (ADCs) and to suggest differential 
      features of hepatic metastases from gastric NETs and ADCs. MATERIALS AND METHODS: 
      Our study population was comprised of 36 patients with gastric NETs (18 WD-NETs, 
      18 PD-NETs) and 38 patients with gastric ADCs who served as our control group. 
      Multiple CT features were assessed to identify significant differential CT 
      findings of PD-NETs from WD-NETs and ADCs. In addition, CT features of hepatic 
      metastases including the metastasis-to-liver ratio were analyzed to differentiate 
      metastatic NETs from ADCs. RESULTS: The presence of metastatic lymph nodes was 
      the sole differentiator of PD-NETs from WD-NETs (P = .001, odds ratio = 56.67), 
      while the presence of intact overlying mucosa with mucosal tenting was the sole 
      significant CT feature differentiating PD-NETs from ADCs (P = .047, odds 
      ratio = 15.3) For hepatic metastases, metastases from NETs were more 
      hyper-attenuated than those from ADCs. CONCLUSION: The presence of metastatic LNs 
      and intact overlying mucosa with mucosal tenting are useful CT discriminators of 
      PD-NETs from WD-NETs and ADCs, respectively. In addition, a higher 
      metastasis-to-liver ratio may help differentiate hepatic metastases of gastric 
      NETs from those of gastric ADCs with high accuracy. KEY POINTS: * Presence of 
      metastatic LNs is a useful differentiator of PD-NETs from WD-NETs. * Intact 
      overlying mucosa with mucosal tenting suggests PD-NETs more than gastric ADCs. * 
      Metastatic LNs are larger in size and greater in necrotic volume in PD-NETs. * 
      Hepatic metastases from gastric NETs are more hyper-attenuated than those from 
      ADCs.
FAU - Kim, Seong Ho
AU  - Kim SH
AD  - Department of Radiology, Seoul National University Hospital, 101, Daehangno, 
      Jongno-gu, Seoul, 110-744, Korea.
FAU - Kim, Se Hyung
AU  - Kim SH
FAU - Kim, Min-A
AU  - Kim MA
FAU - Shin, Cheong-il
AU  - Shin CI
FAU - Han, Joon Koo
AU  - Han JK
FAU - Choi, Byung Ihn
AU  - Choi BI
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150423
PL  - Germany
TA  - Eur Radiol
JT  - European radiology
JID - 9114774
SB  - IM
MH  - Adenocarcinoma/*diagnostic imaging/pathology/secondary
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Liver Neoplasms/*diagnostic imaging/secondary
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Multidetector Computed Tomography
MH  - Neoplasm Seeding
MH  - Neoplasm Staging
MH  - Neuroendocrine Tumors/*diagnostic imaging/pathology/secondary
MH  - Peritoneal Neoplasms/diagnostic imaging/pathology/secondary
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Stomach Neoplasms/*diagnostic imaging/pathology
MH  - Young Adult
EDAT- 2015/04/23 06:00
MHDA- 2015/12/29 06:00
CRDT- 2015/04/23 06:00
PHST- 2014/07/02 00:00 [received]
PHST- 2015/01/13 00:00 [accepted]
PHST- 2014/11/04 00:00 [revised]
PHST- 2015/04/23 06:00 [entrez]
PHST- 2015/04/23 06:00 [pubmed]
PHST- 2015/12/29 06:00 [medline]
AID - 10.1007/s00330-015-3600-z [doi]
PST - ppublish
SO  - Eur Radiol. 2015 Jul;25(7):1946-57. doi: 10.1007/s00330-015-3600-z. Epub 2015 Apr 
      23.