PMID- 25899478
OWN - NLM
STAT- MEDLINE
DCOM- 20160506
LR  - 20230401
IS  - 1943-3654 (Electronic)
IS  - 0020-1324 (Linking)
VI  - 60
IP  - 8
DP  - 2015 Aug
TI  - Bronchial Reactivity, Inflammatory and Allergic Parameters, and Vitamin D Levels 
      in Children With Asthma.
PG  - 1157-63
LID - 10.4187/respcare.03763 [doi]
AB  - BACKGROUND: A low serum vitamin D level may represent a marker of other 
      perplexing factors that may lead to increased asthma prevalence and severity. Our 
      aim was to assess the correlation between vitamin D levels and asthma and allergy 
      markers in a subgroup of children with fewer confounding factors. METHODS: 
      Non-obese children (6-18 y old) with asthma who were not receiving 
      anti-inflammatory treatment were recruited. Subjects underwent spirometry with a 
      methacholine challenge test, and fractional exhaled nitric oxide (FENO), serum 
      vitamin D levels, total immunoglobulin E (IgE) levels, blood eosinophil counts, 
      and high-sensitivity C-reactive protein levels were determined. The primary end 
      point was the correlation between vitamin D level and airway hyper-responsiveness 
      as assessed by a methacholine challenge test. The secondary end point was the 
      correlation between vitamin D level and FENO, systemic inflammatory markers, and 
      allergy. RESULTS: Seventy-one children with asthma (25 females, 35%; 12.5 +/- 3.6 y 
      of age) were included. The median vitamin D level was 23 ng/mL (range of 6-48.5, 
      mean of 23.02 +/- 7.74), the median IgE level was 305 IU/mL (range of 4.3-4,240), 
      the median provocational concentration of methacholine that produced a 20% 
      decrease in FEV1 was 1.1 mg/mL (range of 0-13.9), and the median FENO was 26.5 
      ppb (range of 3.6-285). No correlation was found between vitamin D level and 
      response to the methacholine challenge test, FENO, high-sensitivity C-reactive 
      protein levels, IgE levels, eosinophil counts, and frequency of allergic rhinitis 
      or atopic dermatitis. CONCLUSIONS: In our group of children with asthma, no 
      correlation was found between the level of vitamin D and the degree of airway 
      reactivity, airway inflammation, and allergy. The cause-and-effect relationship 
      between vitamin D, asthma, and allergy should be further clarified. 
      (ClinicalTrials.gov registration NCT01287455).
CI  - Copyright (c) 2015 by Daedalus Enterprises.
FAU - Dabbah, Husein
AU  - Dabbah H
AD  - Department of Pediatrics, Galilee Medical Center, Nahariya, Israel, and the 
      Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel. 
      h_dabbah@rambam.health.gov.il.
FAU - Bar Yoseph, Ronen
AU  - Bar Yoseph R
AD  - Pediatric Pulmonology Unit, Meyer Children's Hospital, Rambam Health Care Campus, 
      Haifa, Israel.
FAU - Livnat, Galit
AU  - Livnat G
AD  - Pediatric Pulmonology Unit, Meyer Children's Hospital, Rambam Health Care Campus, 
      Haifa, Israel.
FAU - Hakim, Fahed
AU  - Hakim F
AD  - Pediatric Pulmonology Unit, Meyer Children's Hospital, Rambam Health Care Campus, 
      Haifa, Israel.
FAU - Bentur, Lea
AU  - Bentur L
AD  - Pediatric Pulmonology Unit, Meyer Children's Hospital, Rambam Health Care Campus, 
      Haifa, Israel. Rappaport Faculty of Medicine, Technion-Israel Institute of 
      Technology, Haifa, Israel.
LA  - eng
SI  - ClinicalTrials.gov/NCT01287455
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150421
PL  - United States
TA  - Respir Care
JT  - Respiratory care
JID - 7510357
RN  - 0 (Biomarkers)
RN  - 0 (Bronchoconstrictor Agents)
RN  - 0 (Inflammation Mediators)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - 1406-16-2 (Vitamin D)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Adolescent
MH  - Asthma/*physiopathology
MH  - Biomarkers/*analysis
MH  - Bronchial Provocation Tests/methods
MH  - Bronchoconstrictor Agents/administration & dosage/analysis
MH  - C-Reactive Protein/analysis
MH  - Child
MH  - Eosinophils
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*blood/complications
MH  - Immunoglobulin E/blood
MH  - Inflammation Mediators/*blood
MH  - Leukocyte Count
MH  - Male
MH  - Methacholine Chloride/administration & dosage/analysis
MH  - Nitric Oxide/analysis
MH  - Pulmonary Elimination
MH  - Spirometry
MH  - Vitamin D/*blood
OTO - NOTNLM
OT  - airway hyper-responsiveness
OT  - allergic parameters
OT  - asthma
OT  - fractional exhaled NO
OT  - high-sensitivity C-reactive protein
OT  - vitamin D
EDAT- 2015/04/23 06:00
MHDA- 2016/05/07 06:00
CRDT- 2015/04/23 06:00
PHST- 2015/04/23 06:00 [entrez]
PHST- 2015/04/23 06:00 [pubmed]
PHST- 2016/05/07 06:00 [medline]
AID - respcare.03763 [pii]
AID - 10.4187/respcare.03763 [doi]
PST - ppublish
SO  - Respir Care. 2015 Aug;60(8):1157-63. doi: 10.4187/respcare.03763. Epub 2015 Apr 
      21.