PMID- 25899686
OWN - NLM
STAT- MEDLINE
DCOM- 20160408
LR  - 20220310
IS  - 1476-511X (Electronic)
IS  - 1476-511X (Linking)
VI  - 14
DP  - 2015 Apr 18
TI  - Lipid metabolism and inflammation modulated by Vitamin D in liver of diabetic 
      rats.
PG  - 31
LID - 10.1186/s12944-015-0030-5 [doi]
LID - 31
AB  - BACKGROUND: In recent years, much evidence suggested that vitamin D plays an 
      important role in decreasing the risk of type 2 diabetes. The purpose of this 
      study was to investigate whether 1, 25 (OH) 2D3 can modulate inflammation and 
      lipid metabolism in type 2 diabetic rat liver. METHODS: Type 2 diabetes was 
      induced in SD rat with high-fat and high-sugar diets and multiple low-dose 
      streptozotocin. The levels of serum calcium, phosphorus, glucose, TC, TG, AST, 
      ALT and hepatic TG were determined. H & E staining were performed to assess the 
      effects of vitamin D treatment on pathological changes in the liver tissues. 
      Immunohistology, real-time PCR and Western blot were used to evaluate the 
      expressions of NF-kappa B, MCP-1, ICAM-1, TGF-beta1, PPAR-alpha and CPT-1. RESULTS: The 
      administration of 1, 25 (OH) 2D3 reduced liver weight. Compared to DM rats, 1, 25 
      (OH) 2D3-treated DM rats had lower liver weight. Moreover, compared to healthy or 
      1, 25 (OH) 2D3-treated DM rats, DM rats had increased hepatic transcription 
      factors (NF-kappa B), monocyte chemoattractant protein -1 (MCP-1), intercellular 
      adhesion molecule -1 (ICAM-1), transforming growth factor-beta1 (TGF-beta1) 
      expressions, but had fewer hepatic PPAR- alpha and CPT-1 expressions. CONCLUSIONS: 1, 
      25 (OH) 2D3 significantly modulated the liver inflammation and lipid metabolism 
      in diabetic rat models, which may be caused by its regulations on hepatic 
      signaling NF-kappa B pathway and PPAR- alpha.
FAU - Ning, Conghua
AU  - Ning C
AD  - Department of Endocrinolog, First Affiliated Hospital of Xinjiang Medical 
      University, No. 137 Liyushannan Road, Urumqi, 830054, Xinjiang, China. 
      xch623@126.com.
FAU - Liu, Lina
AU  - Liu L
AD  - Department of Endocrinolog, First Affiliated Hospital of Xinjiang Medical 
      University, No. 137 Liyushannan Road, Urumqi, 830054, Xinjiang, China. 
      2559435673@qq.com.
FAU - Lv, Guodong
AU  - Lv G
AD  - Institute of Research, The First Affiliated Hospital of Xinjiang Medical 
      University, Urumqi, 830054, Xinjiang, China. xx_1112@sina.cn.
FAU - Yang, Ye
AU  - Yang Y
AD  - Department of Endocrinolog, First Affiliated Hospital of Xinjiang Medical 
      University, No. 137 Liyushannan Road, Urumqi, 830054, Xinjiang, China. 
      cbd_xj@sina.cn.
FAU - Zhang, Yuanyuan
AU  - Zhang Y
AD  - Department of Endocrinolog, First Affiliated Hospital of Xinjiang Medical 
      University, No. 137 Liyushannan Road, Urumqi, 830054, Xinjiang, China. 
      lf_1112@sina.cn.
FAU - Yu, Rui
AU  - Yu R
AD  - Department of Endocrinolog, First Affiliated Hospital of Xinjiang Medical 
      University, No. 137 Liyushannan Road, Urumqi, 830054, Xinjiang, China. 
      yyn_1112@sina.cn.
FAU - Wang, Yongtao
AU  - Wang Y
AD  - Department of Endocrinolog, First Affiliated Hospital of Xinjiang Medical 
      University, No. 137 Liyushannan Road, Urumqi, 830054, Xinjiang, China. 
      mx_1112@sina.cn.
FAU - Zhu, Jun
AU  - Zhu J
AD  - Department of Endocrinolog, First Affiliated Hospital of Xinjiang Medical 
      University, No. 137 Liyushannan Road, Urumqi, 830054, Xinjiang, China. 
      zhujun6677@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150418
PL  - England
TA  - Lipids Health Dis
JT  - Lipids in health and disease
JID - 101147696
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (NF-kappa B)
RN  - 0 (PPAR alpha)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 1406-16-2 (Vitamin D)
RN  - EC 2.3.1.21 (Carnitine O-Palmitoyltransferase)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Carnitine O-Palmitoyltransferase/analysis
MH  - Chemokine CCL2/analysis
MH  - Diabetes Mellitus, Experimental/metabolism/*physiopathology
MH  - Inflammation/metabolism/physiopathology
MH  - Intercellular Adhesion Molecule-1/analysis
MH  - Lipid Metabolism/*drug effects/physiology
MH  - Liver/chemistry/drug effects/*metabolism/pathology/physiopathology
MH  - Male
MH  - NF-kappa B/analysis
MH  - PPAR alpha/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Real-Time Polymerase Chain Reaction
MH  - Transforming Growth Factor beta1/analysis
MH  - Vitamin D/*pharmacology/physiology
PMC - PMC4406219
EDAT- 2015/04/23 06:00
MHDA- 2016/04/09 06:00
PMCR- 2015/04/18
CRDT- 2015/04/23 06:00
PHST- 2015/01/30 00:00 [received]
PHST- 2015/04/01 00:00 [accepted]
PHST- 2015/04/23 06:00 [entrez]
PHST- 2015/04/23 06:00 [pubmed]
PHST- 2016/04/09 06:00 [medline]
PHST- 2015/04/18 00:00 [pmc-release]
AID - 10.1186/s12944-015-0030-5 [pii]
AID - 30 [pii]
AID - 10.1186/s12944-015-0030-5 [doi]
PST - epublish
SO  - Lipids Health Dis. 2015 Apr 18;14:31. doi: 10.1186/s12944-015-0030-5.