PMID- 25902637
OWN - NLM
STAT- MEDLINE
DCOM- 20150901
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 32
IP  - 12
DP  - 2014 Dec
TI  - [Simultaneous determination of 4 kinds of 29 banned and restricted veterinary 
      drugs in animal-derived foods by ultra performance liquid chromatography-tandem 
      mass spectrometry and modified QuEChERS for sample preparation].
PG  - 1313-9
AB  - An ultra performance liquid chromatography-tandem mass spectrometric method, with 
      modified QuEChERS method for sample preparation, was developed for the 
      determination of the 4 kinds of 29 banned and restricted veterinary drugs in 
      chicken muscle, chicken liver, porcine muscle and porcine liver samples. The 
      drugs were extracted with McIlvaine buffer solution and acetonitrile, then 
      cleaned-up by modified QuEChERS method, and finally analyzed by ultra performance 
      liquid chromatography-tandem mass spectrometry in multiple reaction monitoring 
      mode via positive electrospray ionization. The method was validated at three 
      fortification levels (LOQ level, 20 microg/kg and 50 microg/kg) in chicken muscle, 
      chicken liver, porcine muscle and porcine liver samples. The validation results 
      were as follows. The correlation coefficients of the standard calibration curves 
      for the 29 veterinary drugs were all between 0. 993 and 0. 999 over their own 
      concentration ranges. The average recoveries of the 29 drugs were between 71. 5% 
      and 93. 2%, with the relative standard deviations (RSDs) between 0. 8% and 7. 7%. 
      The limits of determination (S/N=3) of the drugs were between 0. 3 and 3. 0 
      microg/kg. The limits of quantification (S/N>/=10) were 1. 0 microg/kg for amantadine, 10.0 
      microg/kg for the tetracycline drugs, and 5. 0 microg/kg for all the other drugs. It was 
      indicated that the method developed is easy, sensitive, and has a good 
      purification effect. The sensitivity, accuracy and precision of the method were 
      all acceptable, and it can meet the requirements of the multiple residue 
      analysis. So, this method can be further applied to investigate the veterinary 
      drug residues in animal derived foods.
FAU - Li, Na
AU  - Li N
FAU - Zhang, Yuting
AU  - Zhang Y
FAU - Lui, Lei
AU  - Lui L
FAU - Shao, Hui
AU  - Shao H
FAU - Li, Hui
AU  - Li H
FAU - Li, Jing
AU  - Li J
FAU - Guo, Yongze
AU  - Guo Y
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Veterinary Drugs)
SB  - IM
MH  - Animals
MH  - Chickens
MH  - Chromatography, High Pressure Liquid
MH  - Drug Residues/*analysis
MH  - Liver/chemistry
MH  - Mass Spectrometry
MH  - Meat/*analysis
MH  - Muscles/chemistry
MH  - Swine
MH  - *Tandem Mass Spectrometry
MH  - Veterinary Drugs/*analysis
EDAT- 2015/04/24 06:00
MHDA- 2015/09/02 06:00
CRDT- 2015/04/24 06:00
PHST- 2015/04/24 06:00 [entrez]
PHST- 2015/04/24 06:00 [pubmed]
PHST- 2015/09/02 06:00 [medline]
AID - 10.3724/sp.j.1123.2014.07044 [doi]
PST - ppublish
SO  - Se Pu. 2014 Dec;32(12):1313-9. doi: 10.3724/sp.j.1123.2014.07044.